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Murcko scaffold

Ring system with 4 rings and 22 atoms

840 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
840
With full pages
15
Scaffold SMILES

O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 241 to 288 of 840 chemicals

2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-methoxycyclobutyl]acetic acid chemical structure, C22H23NO5, CAS 2142517-41-5
2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-methoxycyclobutyl]acetic acid
CAS 2142517-41-5C22H23NO5
2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-5,5-dimethylhexanoic acid chemical structure, C28H34N2O5, CAS 2171291-55-5
2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-5,5-dimethylhexanoic acid
CAS 2171291-55-5C28H34N2O5
(2S)-3-(Dimethylamino)-2-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid chemical structure, C25H29N3O5, CAS 2171279-11-9
(2S)-3-(Dimethylamino)-2-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid
CAS 2171279-11-9C25H29N3O5
4-{N-Ethyl-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid chemical structure, C27H32N2O5, CAS 2172179-76-7
4-{N-Ethyl-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid
CAS 2172179-76-7C27H32N2O5
(2S)-3-(Dimethylamino)-2-{2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}propanoic acid chemical structure, C26H31N3O5, CAS 2171143-47-6
(2S)-3-(Dimethylamino)-2-{2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}propanoic acid
CAS 2171143-47-6C26H31N3O5
2-({[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)-3,3,3-trifluoropropanoic acid chemical structure, C24H23F3N2O5, CAS 2172208-11-4
2-({[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)-3,3,3-trifluoropropanoic acid
CAS 2172208-11-4C24H23F3N2O5
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-propylacetamido}propanoic acid chemical structure, C27H32N2O5, CAS 2171832-49-6
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-propylacetamido}propanoic acid
CAS 2171832-49-6C27H32N2O5
4-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3,3-dimethylbutanoic acid chemical structure, C27H32N2O5, CAS 2171967-08-9
4-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3,3-dimethylbutanoic acid
CAS 2171967-08-9C27H32N2O5
(3S)-3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}hexanoic acid chemical structure, C27H32N2O5, CAS 2171157-31-4
(3S)-3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}hexanoic acid
CAS 2171157-31-4C27H32N2O5
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}hexanoic acid chemical structure, C26H30N2O5, CAS 2171178-85-9
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}hexanoic acid
CAS 2171178-85-9C26H30N2O5
(3R)-3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}hexanoic acid chemical structure, C27H32N2O5, CAS 2171230-15-0
(3R)-3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}hexanoic acid
CAS 2171230-15-0C27H32N2O5
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylacetamido}-2-methylpropanoic acid chemical structure, C26H30N2O5, CAS 2172274-80-3
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylacetamido}-2-methylpropanoic acid
CAS 2172274-80-3C26H30N2O5
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(prop-2-yn-1-yl)acetamido}acetic acid chemical structure, C26H26N2O5, CAS 2172514-90-6
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(prop-2-yn-1-yl)acetamido}acetic acid
CAS 2172514-90-6C26H26N2O5
5-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4-methylpentanoic acid chemical structure, C27H32N2O5, CAS 2172115-41-0
5-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4-methylpentanoic acid
CAS 2172115-41-0C27H32N2O5
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}acetic acid chemical structure, C23H24N2O5, CAS 2172177-29-4
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}acetic acid
CAS 2172177-29-4C23H24N2O5
3-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}propanoic acid chemical structure, C24H26N2O5, CAS 2172236-42-7
3-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}propanoic acid
CAS 2172236-42-7C24H26N2O5
2-({2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}oxy)acetic acid chemical structure, C23H24N2O6, CAS 2172236-51-8
2-({2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}oxy)acetic acid
CAS 2172236-51-8C23H24N2O6
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-hydroxybutanoic acid chemical structure, C24H26N2O6, CAS 2171163-55-4
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-hydroxybutanoic acid
CAS 2171163-55-4C24H26N2O6
3-({[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)-5-methylhexanoic acid chemical structure, C28H34N2O5, CAS 2171887-11-7
3-({[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)-5-methylhexanoic acid
CAS 2171887-11-7C28H34N2O5
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-hydroxypropanoic acid chemical structure, C23H24N2O6, CAS 2171259-15-5
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-hydroxypropanoic acid
CAS 2171259-15-5C23H24N2O6
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4,4-difluorobutanoic acid chemical structure, C24H24F2N2O5, CAS 2171757-29-0
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4,4-difluorobutanoic acid
CAS 2171757-29-0C24H24F2N2O5
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-hydroxypropanoic acid chemical structure, C24H26N2O6, CAS 2172209-22-0
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-hydroxypropanoic acid
CAS 2172209-22-0C24H26N2O6
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylacetamido}propanoic acid chemical structure, C25H28N2O5, CAS 2172216-84-9
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylacetamido}propanoic acid
CAS 2172216-84-9C25H28N2O5
3-{[3-Ethoxy-1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylcyclobutyl]formamido}propanoic acid chemical structure, C27H32N2O6, CAS 2171673-11-1
3-{[3-Ethoxy-1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylcyclobutyl]formamido}propanoic acid
CAS 2171673-11-1C27H32N2O6