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Murcko scaffold

Ring system with 4 rings and 22 atoms

840 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
840
With full pages
15
Scaffold SMILES

O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 337 to 384 of 840 chemicals

(2S)-4-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-hydroxybutanoic acid chemical structure, C24H26N2O6, CAS 2171192-44-0
(2S)-4-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-hydroxybutanoic acid
CAS 2171192-44-0C24H26N2O6
5-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylpentanoic acid chemical structure, C27H32N2O5, CAS 2172082-73-2
5-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylpentanoic acid
CAS 2172082-73-2C27H32N2O5
2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}acetic acid chemical structure, C23H24N2O5, CAS 2172238-35-4
2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}acetic acid
CAS 2172238-35-4C23H24N2O5
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid chemical structure, C23H24N2O5, CAS 2171185-47-8
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid
CAS 2171185-47-8C23H24N2O5
(2R)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid chemical structure, C23H24N2O5, CAS 2171150-27-7
(2R)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid
CAS 2171150-27-7C23H24N2O5
2-Ethyl-2-({2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}methyl)butanoic acid chemical structure, C28H34N2O5, CAS 2172146-48-2
2-Ethyl-2-({2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}methyl)butanoic acid
CAS 2172146-48-2C28H34N2O5
(2S)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3-hydroxypropanoic acid chemical structure, C24H26N2O6, CAS 2171158-74-8
(2S)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3-hydroxypropanoic acid
CAS 2171158-74-8C24H26N2O6
2-{N-Ethyl-2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}acetic acid chemical structure, C25H28N2O5, CAS 2171821-82-0
2-{N-Ethyl-2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}acetic acid
CAS 2171821-82-0C25H28N2O5
2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-propylformamido}acetic acid chemical structure, C25H28N2O5, CAS 2172045-13-3
2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-propylformamido}acetic acid
CAS 2172045-13-3C25H28N2O5
(2S)-3-(Dimethylamino)-2-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}propanoic acid chemical structure, C26H31N3O5, CAS 2171284-84-5
(2S)-3-(Dimethylamino)-2-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}propanoic acid
CAS 2171284-84-5C26H31N3O5
3-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(propan-2-yl)formamido}propanoic acid chemical structure, C26H30N2O5, CAS 2171198-55-1
3-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(propan-2-yl)formamido}propanoic acid
CAS 2171198-55-1C26H30N2O5
4-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}but-2-enoic acid chemical structure, C24H24N2O5, CAS 2171243-43-7
4-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}but-2-enoic acid
CAS 2171243-43-7C24H24N2O5
2-({[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}oxy)-3-methoxypropanoic acid chemical structure, C24H26N2O7, CAS 2172238-21-8
2-({[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}oxy)-3-methoxypropanoic acid
CAS 2172238-21-8C24H26N2O7
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3-hydroxy-2-methylpropanoic acid chemical structure, C25H28N2O6, CAS 2171893-24-4
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3-hydroxy-2-methylpropanoic acid
CAS 2171893-24-4C25H28N2O6
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-5-methylhex-4-enoic acid chemical structure, C28H32N2O5, CAS 2171528-31-5
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-5-methylhex-4-enoic acid
CAS 2171528-31-5C28H32N2O5
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}hex-5-enoic acid chemical structure, C27H30N2O5, CAS 2171597-35-4
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}hex-5-enoic acid
CAS 2171597-35-4C27H30N2O5
3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}propanoic acid chemical structure, C24H26N2O5, CAS 2172039-94-8
3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}propanoic acid
CAS 2172039-94-8C24H26N2O5
3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylacetamido}propanoic acid chemical structure, C25H28N2O5, CAS 2171885-82-6
3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylacetamido}propanoic acid
CAS 2171885-82-6C25H28N2O5
4-(Dimethylamino)-2-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid chemical structure, C27H33N3O5, CAS 2171714-55-7
4-(Dimethylamino)-2-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid
CAS 2171714-55-7C27H33N3O5
4-(Dimethylamino)-2-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}butanoic acid chemical structure, C26H31N3O5, CAS 2171292-50-3
4-(Dimethylamino)-2-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}butanoic acid
CAS 2171292-50-3C26H31N3O5
2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-5-methoxypentanoic acid chemical structure, C26H30N2O6, CAS 2171299-52-6
2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-5-methoxypentanoic acid
CAS 2171299-52-6C26H30N2O6
3-(Dimethylamino)-2-{[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid chemical structure, C25H29N3O5, CAS 2171760-68-0
3-(Dimethylamino)-2-{[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid
CAS 2171760-68-0C25H29N3O5
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}pent-4-enoic acid chemical structure, C26H28N2O5, CAS 2171677-08-8
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}pent-4-enoic acid
CAS 2171677-08-8C26H28N2O5
3-{N-Ethyl-1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid chemical structure, C25H28N2O5, CAS 2171184-86-2
3-{N-Ethyl-1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid
CAS 2171184-86-2C25H28N2O5