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Murcko scaffold

Pyrrolidine, 1-(N-phenylglycyl)- scaffold

40 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
40
With full pages
14
Scaffold SMILES

O=C(CNc1ccccc1)N1CCCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Pyrrolidine, 1-(N-phenylglycyl)- page
Murcko scaffold O=C(CNc1ccccc1)N1CCCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 40 of 40 chemicals

N-(3,4-Dimethylphenyl)-N-(2-oxo-2-pyrrolidin-1-ylethyl)methanesulfonamide chemical structure, C15H22N2O3S, CAS 460044-50-2
N-(3,4-Dimethylphenyl)-N-(2-oxo-2-pyrrolidin-1-ylethyl)methanesulfonamide
CAS 460044-50-2C15H22N2O3S
N-(2,3-Dimethylphenyl)-N-(2-oxo-2-pyrrolidin-1-ylethyl)methanesulfonamide chemical structure, C15H22N2O3S, CAS 432005-19-1
N-(2,3-Dimethylphenyl)-N-(2-oxo-2-pyrrolidin-1-ylethyl)methanesulfonamide
CAS 432005-19-1C15H22N2O3S
N-(2-Ethyl-phenyl)-N-(2-oxo-2-pyrrolidin-1-yl-ethyl)-methanesulfonamide chemical structure, C15H22N2O3S, CAS 6202-35-3
N-(2-Ethyl-phenyl)-N-(2-oxo-2-pyrrolidin-1-yl-ethyl)-methanesulfonamide
CAS 6202-35-3C15H22N2O3S
N-(5-Chloro-2-methylphenyl)-N-(2-oxo-2-pyrrolidin-1-ylethyl)methanesulfonamide chemical structure, C14H19ClN2O3S, CAS 503838-41-3
N-(5-Chloro-2-methylphenyl)-N-(2-oxo-2-pyrrolidin-1-ylethyl)methanesulfonamide
CAS 503838-41-3C14H19ClN2O3S
N-(2-Fluorophenyl)-N-(2-oxo-2-pyrrolidin-1-ylethyl)methanesulfonamide chemical structure, C13H17FN2O3S, CAS 425424-92-6
N-(2-Fluorophenyl)-N-(2-oxo-2-pyrrolidin-1-ylethyl)methanesulfonamide
CAS 425424-92-6C13H17FN2O3S
N-(2,5-Dichlorophenyl)-N-[2-oxo-2-(pyrrolidin-1-yl)ethyl]methanesulfonamide chemical structure, C13H16Cl2N2O3S, CAS 690689-83-9
N-(2,5-Dichlorophenyl)-N-[2-oxo-2-(pyrrolidin-1-yl)ethyl]methanesulfonamide
CAS 690689-83-9C13H16Cl2N2O3S
N-(2,4-Dichlorophenyl)-N-[2-oxo-2-(pyrrolidin-1-yl)ethyl]methanesulfonamide chemical structure, C13H16Cl2N2O3S, CAS 714206-64-1
N-(2,4-Dichlorophenyl)-N-[2-oxo-2-(pyrrolidin-1-yl)ethyl]methanesulfonamide
CAS 714206-64-1C13H16Cl2N2O3S
N-(2,4-Dimethoxyphenyl)-N-(2-oxo-2-pyrrolidin-1-ylethyl)methanesulfonamide chemical structure, C15H22N2O5S, CAS 425618-02-6
N-(2,4-Dimethoxyphenyl)-N-(2-oxo-2-pyrrolidin-1-ylethyl)methanesulfonamide
CAS 425618-02-6C15H22N2O5S
N-[4-Chloro-3-(trifluoromethyl)phenyl]-N-(2-oxo-2-pyrrolidin-1-ylethyl)methanesulfonamide chemical structure, C14H16ClF3N2O3S, CAS 333458-63-2
N-[4-Chloro-3-(trifluoromethyl)phenyl]-N-(2-oxo-2-pyrrolidin-1-ylethyl)methanesulfonamide
CAS 333458-63-2C14H16ClF3N2O3S
N-(2,3-Dichlorophenyl)-N-(2-oxo-2-pyrrolidin-1-ylethyl)methanesulfonamide chemical structure, C13H16Cl2N2O3S, CAS 433233-50-2
N-(2,3-Dichlorophenyl)-N-(2-oxo-2-pyrrolidin-1-ylethyl)methanesulfonamide
CAS 433233-50-2C13H16Cl2N2O3S
N-(4-Methoxyphenyl)-N-(1-oxo-1-pyrrolidin-1-ylpropan-2-yl)methanesulfonamide chemical structure, C15H22N2O4S, CAS 1008050-88-1
N-(4-Methoxyphenyl)-N-(1-oxo-1-pyrrolidin-1-ylpropan-2-yl)methanesulfonamide
CAS 1008050-88-1C15H22N2O4S
N-(1-Oxo-1-pyrrolidin-1-ylpropan-2-yl)-N-phenylmethanesulfonamide chemical structure, C14H20N2O3S, CAS 1008201-71-5
N-(1-Oxo-1-pyrrolidin-1-ylpropan-2-yl)-N-phenylmethanesulfonamide
CAS 1008201-71-5C14H20N2O3S
N-(4-Ethoxyphenyl)-N-(1-oxo-1-pyrrolidin-1-ylpropan-2-yl)methanesulfonamide chemical structure, C16H24N2O4S, CAS 474087-85-9
N-(4-Ethoxyphenyl)-N-(1-oxo-1-pyrrolidin-1-ylpropan-2-yl)methanesulfonamide
CAS 474087-85-9C16H24N2O4S
N-(3,4-Dimethylphenyl)-N-(1-oxo-1-pyrrolidin-1-ylpropan-2-yl)methanesulfonamide chemical structure, C16H24N2O3S, CAS 1008578-04-8
N-(3,4-Dimethylphenyl)-N-(1-oxo-1-pyrrolidin-1-ylpropan-2-yl)methanesulfonamide
CAS 1008578-04-8C16H24N2O3S
N-(4-Chlorophenyl)-N-(1-oxo-1-pyrrolidin-1-ylpropan-2-yl)methanesulfonamide chemical structure, C14H19ClN2O3S, CAS 1008002-92-3
N-(4-Chlorophenyl)-N-(1-oxo-1-pyrrolidin-1-ylpropan-2-yl)methanesulfonamide
CAS 1008002-92-3C14H19ClN2O3S
N-(3,5-Dimethylphenyl)-N-(1-oxo-1-pyrrolidin-1-ylpropan-2-yl)methanesulfonamide chemical structure, C16H24N2O3S, CAS 1008941-91-0
N-(3,5-Dimethylphenyl)-N-(1-oxo-1-pyrrolidin-1-ylpropan-2-yl)methanesulfonamide
CAS 1008941-91-0C16H24N2O3S
N-(3-Chlorophenyl)-N-(1-oxo-1-pyrrolidin-1-ylpropan-2-yl)methanesulfonamide chemical structure, C14H19ClN2O3S, CAS 1008233-78-0
N-(3-Chlorophenyl)-N-(1-oxo-1-pyrrolidin-1-ylpropan-2-yl)methanesulfonamide
CAS 1008233-78-0C14H19ClN2O3S
Pyrrolidine, 1-(N-phenylglycyl)- chemical structure, C12H16N2O, CAS 91557-13-0
Pyrrolidine, 1-(N-phenylglycyl)-
CAS 91557-13-0C12H16N2O
N-(1-(1-Pyrrolidinylcarbonyl)ethyl)propionanilide chemical structure, C16H22N2O2, CAS 97020-73-0
N-(1-(1-Pyrrolidinylcarbonyl)ethyl)propionanilide
CAS 97020-73-0C16H22N2O2
Pyrrolidine, 1-(N-2,6-xylylglycyl)- chemical structure, C14H20N2O, CAS 60277-11-4
Pyrrolidine, 1-(N-2,6-xylylglycyl)-
CAS 60277-11-4C14H20N2O
N-(1-Methyl-2-oxo-2-pyrrolidin-1-yl-ethyl)-N-p-tolyl-methanesulfonamide chemical structure, C15H22N2O3S, CAS 1008280-91-8
N-(1-Methyl-2-oxo-2-pyrrolidin-1-yl-ethyl)-N-p-tolyl-methanesulfonamide
CAS 1008280-91-8C15H22N2O3S
2-(5-Chloro-2,4-dimethoxyanilino)-1-pyrrolidin-1-ylpropan-1-one chemical structure, C15H21ClN2O3, CAS 1008972-21-1
2-(5-Chloro-2,4-dimethoxyanilino)-1-pyrrolidin-1-ylpropan-1-one
CAS 1008972-21-1C15H21ClN2O3
N-(3,4-Difluorophenyl)-N-[2-oxo-2-(pyrrolidin-1-yl)ethyl]methanesulfonamide chemical structure, C13H16F2N2O3S, CAS 892676-50-5
N-(3,4-Difluorophenyl)-N-[2-oxo-2-(pyrrolidin-1-yl)ethyl]methanesulfonamide
CAS 892676-50-5C13H16F2N2O3S
2-[(3,5-Dimethoxyphenyl)amino]-1-(pyrrolidin-1-yl)propan-1-one chemical structure, C15H22N2O3, CAS 1046468-42-1
2-[(3,5-Dimethoxyphenyl)amino]-1-(pyrrolidin-1-yl)propan-1-one
CAS 1046468-42-1C15H22N2O3