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Murcko scaffold

1-(Benzylsulfonyl)-4-phenylpiperazine scaffold

30 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
30
With full pages
7
Scaffold SMILES

O=S(=O)(Cc1ccccc1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Benzylsulfonyl)-4-phenylpiperazine page
Murcko scaffold O=S(=O)(Cc1ccccc1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 30 of 30 chemicals

1-(2-Nitro-phenyl)-4-phenylmethanesulfonyl-piperazine chemical structure, C17H19N3O4S, CAS 432526-13-1
1-(2-Nitro-phenyl)-4-phenylmethanesulfonyl-piperazine
CAS 432526-13-1C17H19N3O4S
1-(Benzylsulfonyl)-4-(4-fluorophenyl)piperazine chemical structure, C17H19FN2O2S, CAS 321532-02-9
1-(Benzylsulfonyl)-4-(4-fluorophenyl)piperazine
CAS 321532-02-9C17H19FN2O2S
1-(Benzylsulfonyl)-4-phenylpiperazine chemical structure, C17H20N2O2S, CAS 107785-35-3
1-(Benzylsulfonyl)-4-phenylpiperazine
CAS 107785-35-3C17H20N2O2S
1-Benzylsulfonyl-4-(4-methoxyphenyl)piperazine chemical structure, C18H22N2O3S, CAS 694453-80-0
1-Benzylsulfonyl-4-(4-methoxyphenyl)piperazine
CAS 694453-80-0C18H22N2O3S
1-Benzylsulfonyl-4-(3-chlorophenyl)piperazine chemical structure, C17H19ClN2O2S, CAS 330469-55-1
1-Benzylsulfonyl-4-(3-chlorophenyl)piperazine
CAS 330469-55-1C17H19ClN2O2S
1-[(4-Chlorophenyl)methylsulfonyl]-4-phenylpiperazine chemical structure, C17H19ClN2O2S, CAS 827619-70-5
1-[(4-Chlorophenyl)methylsulfonyl]-4-phenylpiperazine
CAS 827619-70-5C17H19ClN2O2S
1-(Benzylsulfonyl)-4-(4-nitrophenyl)piperazine chemical structure, C17H19N3O4S, CAS 5569-57-3
1-(Benzylsulfonyl)-4-(4-nitrophenyl)piperazine
CAS 5569-57-3C17H19N3O4S
1-(Benzylsulfonyl)-4-(2-chloro-4-nitrophenyl)piperazine chemical structure, C17H18ClN3O4S, CAS 330633-74-4
1-(Benzylsulfonyl)-4-(2-chloro-4-nitrophenyl)piperazine
CAS 330633-74-4C17H18ClN3O4S
1-Benzylsulfonyl-4-(2-chloro-6-nitrophenyl)piperazine chemical structure, C17H18ClN3O4S, CAS 380595-59-5
1-Benzylsulfonyl-4-(2-chloro-6-nitrophenyl)piperazine
CAS 380595-59-5C17H18ClN3O4S
1-Benzylsulfonyl-4-[2-nitro-4-(trifluoromethyl)phenyl]piperazine chemical structure, C18H18F3N3O4S, CAS 383370-88-5
1-Benzylsulfonyl-4-[2-nitro-4-(trifluoromethyl)phenyl]piperazine
CAS 383370-88-5C18H18F3N3O4S
1-Benzylsulfonyl-4-(4-chloro-2-nitrophenyl)piperazine chemical structure, C17H18ClN3O4S, CAS 430455-37-1
1-Benzylsulfonyl-4-(4-chloro-2-nitrophenyl)piperazine
CAS 430455-37-1C17H18ClN3O4S
1-Benzylsulfonyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine chemical structure, C18H18F3N3O4S, CAS 432500-12-4
1-Benzylsulfonyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine
CAS 432500-12-4C18H18F3N3O4S
1-Benzylsulfonyl-2-methyl-4-(4-nitrophenyl)piperazine chemical structure, C18H21N3O4S, CAS 524034-02-4
1-Benzylsulfonyl-2-methyl-4-(4-nitrophenyl)piperazine
CAS 524034-02-4C18H21N3O4S
5-(4-Benzylsulfonylpiperazin-1-yl)-N-ethyl-2-nitroaniline chemical structure, C19H24N4O4S, CAS 708252-34-0
5-(4-Benzylsulfonylpiperazin-1-yl)-N-ethyl-2-nitroaniline
CAS 708252-34-0C19H24N4O4S
1-[(4-Chlorobenzyl)sulfonyl]-4-(4-nitrophenyl)piperazine chemical structure, C17H18ClN3O4S, CAS 827620-01-9
1-[(4-Chlorobenzyl)sulfonyl]-4-(4-nitrophenyl)piperazine
CAS 827620-01-9C17H18ClN3O4S
1-[(2-Chlorobenzyl)sulfonyl]-4-(4-nitrophenyl)piperazine chemical structure, C17H18ClN3O4S, CAS 878985-13-8
1-[(2-Chlorobenzyl)sulfonyl]-4-(4-nitrophenyl)piperazine
CAS 878985-13-8C17H18ClN3O4S
1-[(2-Chlorophenyl)methylsulfonyl]-4-(4-fluorophenyl)piperazine chemical structure, C17H18ClFN2O2S, CAS 878984-70-4
1-[(2-Chlorophenyl)methylsulfonyl]-4-(4-fluorophenyl)piperazine
CAS 878984-70-4C17H18ClFN2O2S
1-[(2-Chlorophenyl)methylsulfonyl]-4-(2-fluorophenyl)piperazine chemical structure, C17H18ClFN2O2S, CAS 881950-15-8
1-[(2-Chlorophenyl)methylsulfonyl]-4-(2-fluorophenyl)piperazine
CAS 881950-15-8C17H18ClFN2O2S
1-[(4-Chlorophenyl)methylsulfonyl]-4-(4-fluorophenyl)piperazine chemical structure, C17H18ClFN2O2S, CAS 879029-79-5
1-[(4-Chlorophenyl)methylsulfonyl]-4-(4-fluorophenyl)piperazine
CAS 879029-79-5C17H18ClFN2O2S
1-[(3-Chlorobenzyl)sulfonyl]-4-(4-fluorophenyl)piperazine chemical structure, C17H18ClFN2O2S, CAS 950252-48-9
1-[(3-Chlorobenzyl)sulfonyl]-4-(4-fluorophenyl)piperazine
CAS 950252-48-9C17H18ClFN2O2S
1-(3-Chlorophenyl)-4-[(4-fluorobenzyl)sulfonyl]piperazine chemical structure, C17H18ClFN2O2S, CAS 950247-61-7
1-(3-Chlorophenyl)-4-[(4-fluorobenzyl)sulfonyl]piperazine
CAS 950247-61-7C17H18ClFN2O2S
1-[(4-Fluorobenzyl)sulfonyl]-4-(2-methoxyphenyl)piperazine chemical structure, C18H21FN2O3S, CAS 950232-42-5
1-[(4-Fluorobenzyl)sulfonyl]-4-(2-methoxyphenyl)piperazine
CAS 950232-42-5C18H21FN2O3S
1-[(4-Fluorobenzyl)sulfonyl]-4-(4-methoxyphenyl)piperazine chemical structure, C18H21FN2O3S, CAS 950233-89-3
1-[(4-Fluorobenzyl)sulfonyl]-4-(4-methoxyphenyl)piperazine
CAS 950233-89-3C18H21FN2O3S
1-(3-Chlorophenyl)-4-[(2-fluorobenzyl)sulfonyl]piperazine chemical structure, C17H18ClFN2O2S, CAS 950233-06-4
1-(3-Chlorophenyl)-4-[(2-fluorobenzyl)sulfonyl]piperazine
CAS 950233-06-4C17H18ClFN2O2S