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Murcko scaffold

Piperazine, 1-phenethyl-4-phenyl- scaffold

130 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
130
With full pages
21
Scaffold SMILES

c1ccc(CCN2CCN(c3ccccc3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Piperazine, 1-phenethyl-4-phenyl- page
Murcko scaffold c1ccc(CCN2CCN(c3ccccc3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 130 chemicals

Acetanilide, 2'-(4-(3,4-dimethoxyphenethyl)-1-piperazinyl)- chemical structure, C22H29N3O3, CAS 1250-37-9
Acetanilide, 2'-(4-(3,4-dimethoxyphenethyl)-1-piperazinyl)-
CAS 1250-37-9C22H29N3O3
Piperazine, 1-(m-chlorophenyl)-4-(3,4-dimethoxyphenethyl)- chemical structure, C20H25ClN2O2, CAS 1049-99-6
Piperazine, 1-(m-chlorophenyl)-4-(3,4-dimethoxyphenethyl)-
CAS 1049-99-6C20H25ClN2O2
4-(1-Hydroxy-2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-1,2-benzenediol chemical structure, C19H24N2O4, CAS 15534-05-1
4-(1-Hydroxy-2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-1,2-benzenediol
CAS 15534-05-1C19H24N2O4
N-(1,1-Dimethylethyl)-4-(2-methoxyphenyl)-alpha-phenyl-1-piperazinepropanamide chemical structure, C24H33N3O2, CAS 133025-23-7
N-(1,1-Dimethylethyl)-4-(2-methoxyphenyl)-alpha-phenyl-1-piperazinepropanamide
CAS 133025-23-7C24H33N3O2
Piperazine, 1-phenethyl-4-phenyl- chemical structure, C18H22N2, CAS 1033-68-7
Piperazine, 1-phenethyl-4-phenyl-
CAS 1033-68-7C18H22N2
Piperazine, 1-(m-methoxyphenethyl)-4-phenyl- chemical structure, C19H24N2O, CAS 1040-88-6
Piperazine, 1-(m-methoxyphenethyl)-4-phenyl-
CAS 1040-88-6C19H24N2O
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(2,5-dimethoxyphenyl)-, hydrochloride chemical structure, C22H31ClN2O4, CAS 1755-84-6
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(2,5-dimethoxyphenyl)-, hydrochloride
CAS 1755-84-6C22H31ClN2O4
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-phenyl- chemical structure, C20H26N2O2, CAS 1047-68-3
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-phenyl-
CAS 1047-68-3C20H26N2O2
Piperazine, 1-(o-bromophenyl)-4-(3,4-dimethoxyphenethyl)- chemical structure, C20H25BrN2O2, CAS 1049-78-1
Piperazine, 1-(o-bromophenyl)-4-(3,4-dimethoxyphenethyl)-
CAS 1049-78-1C20H25BrN2O2
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(o-tolyl)- chemical structure, C21H28N2O2, CAS 1049-79-2
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(o-tolyl)-
CAS 1049-79-2C21H28N2O2
Piperazine, 1-(o-aminophenyl)-4-(3,4-dimethoxyphenethyl)- chemical structure, C20H27N3O2, CAS 1049-80-5
Piperazine, 1-(o-aminophenyl)-4-(3,4-dimethoxyphenethyl)-
CAS 1049-80-5C20H27N3O2
Phenol, o-(4-(3,4-dimethoxyphenethyl)-1-piperazinyl)- chemical structure, C20H26N2O3, CAS 1049-81-6
Phenol, o-(4-(3,4-dimethoxyphenethyl)-1-piperazinyl)-
CAS 1049-81-6C20H26N2O3
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(p-tolyl)- chemical structure, C21H28N2O2, CAS 1050-03-9
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(p-tolyl)-
CAS 1050-03-9C21H28N2O2
Piperazine, 1-(p-chlorophenyl)-4-(3,4-dimethoxyphenethyl)- chemical structure, C20H25ClN2O2, CAS 1050-04-0
Piperazine, 1-(p-chlorophenyl)-4-(3,4-dimethoxyphenethyl)-
CAS 1050-04-0C20H25ClN2O2
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(2,6-xylyl)- chemical structure, C22H30N2O2, CAS 1051-24-7
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(2,6-xylyl)-
CAS 1051-24-7C22H30N2O2
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(o-(methylthio)phenyl)- chemical structure, C21H28N2O2S, CAS 1051-73-6
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(o-(methylthio)phenyl)-
CAS 1051-73-6C21H28N2O2S
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(2,3-xylyl)- chemical structure, C22H30N2O2, CAS 1052-00-2
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(2,3-xylyl)-
CAS 1052-00-2C22H30N2O2
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(3,4-xylyl)- chemical structure, C22H30N2O2, CAS 1052-20-6
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(3,4-xylyl)-
CAS 1052-20-6C22H30N2O2
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(m-methoxyphenyl)- chemical structure, C21H28N2O3, CAS 1052-21-7
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(m-methoxyphenyl)-
CAS 1052-21-7C21H28N2O3
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(p-methoxyphenyl)- chemical structure, C21H28N2O3, CAS 1052-26-2
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(p-methoxyphenyl)-
CAS 1052-26-2C21H28N2O3
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(o-fluorophenyl)- chemical structure, C20H25FN2O2, CAS 1243-34-1
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(o-fluorophenyl)-
CAS 1243-34-1C20H25FN2O2
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(m-tolyl)- chemical structure, C21H28N2O2, CAS 1243-53-4
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(m-tolyl)-
CAS 1243-53-4C21H28N2O2
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(o-methoxyphenyl)- chemical structure, C21H28N2O3, CAS 1245-28-9
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(o-methoxyphenyl)-
CAS 1245-28-9C21H28N2O3
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(2,4-xylyl)- chemical structure, C22H30N2O2, CAS 1245-35-8
Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(2,4-xylyl)-
CAS 1245-35-8C22H30N2O2