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Murcko scaffold

Ring system with 3 rings and 20 atoms

89 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
89
With full pages
17
Scaffold SMILES

c1ccc(CNc2ccc(N3CCOCC3)cc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(CNc2ccc(N3CCOCC3)cc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 89 chemicals

5-[(2-Ethoxybenzyl)amino]-2-(4-morpholinyl)benzoic acid chemical structure, C20H24N2O4, CAS 765933-72-0
5-[(2-Ethoxybenzyl)amino]-2-(4-morpholinyl)benzoic acid
CAS 765933-72-0C20H24N2O4
2-(4-Morpholinyl)-5-{[2-(trifluoromethyl)benzyl]amino}benzoic acid chemical structure, C19H19F3N2O3, CAS 765925-10-8
2-(4-Morpholinyl)-5-{[2-(trifluoromethyl)benzyl]amino}benzoic acid
CAS 765925-10-8C19H19F3N2O3
Methyl 5-[(2-chloro-6-fluorophenyl)methylamino]-2-morpholin-4-ylbenzoate chemical structure, C19H20ClFN2O3, CAS 766527-40-6
Methyl 5-[(2-chloro-6-fluorophenyl)methylamino]-2-morpholin-4-ylbenzoate
CAS 766527-40-6C19H20ClFN2O3
5-[[4-(2-Amino-2-oxoethoxy)-3-methoxyphenyl]methylamino]-2-(4-morpholinyl)benzoic acid chemical structure, C21H25N3O6, CAS 765924-80-9
5-[[4-(2-Amino-2-oxoethoxy)-3-methoxyphenyl]methylamino]-2-(4-morpholinyl)benzoic acid
CAS 765924-80-9C21H25N3O6
Methyl 5-[(2-fluorophenyl)methylamino]-2-morpholin-4-ylbenzoate chemical structure, C19H21FN2O3, CAS 766527-52-0
Methyl 5-[(2-fluorophenyl)methylamino]-2-morpholin-4-ylbenzoate
CAS 766527-52-0C19H21FN2O3
5-[(2-Methoxybenzyl)amino]-2-(4-morpholinyl)benzoic acid chemical structure, C19H22N2O4, CAS 765924-78-5
5-[(2-Methoxybenzyl)amino]-2-(4-morpholinyl)benzoic acid
CAS 765924-78-5C19H22N2O4
5-[(2-Chloro-6-fluorobenzyl)amino]-2-(4-morpholinyl)benzoic acid chemical structure, C18H18ClFN2O3, CAS 765933-61-7
5-[(2-Chloro-6-fluorobenzyl)amino]-2-(4-morpholinyl)benzoic acid
CAS 765933-61-7C18H18ClFN2O3
N-(2-Methoxybenzyl)-4-(morpholin-4-yl)aniline chemical structure, C18H22N2O2, CAS 353760-63-1
N-(2-Methoxybenzyl)-4-(morpholin-4-yl)aniline
CAS 353760-63-1C18H22N2O2
3-Chloro-N-[(4-methylsulfanylphenyl)methyl]-4-morpholin-4-ylaniline chemical structure, C18H21ClN2OS, CAS 717865-35-5
3-Chloro-N-[(4-methylsulfanylphenyl)methyl]-4-morpholin-4-ylaniline
CAS 717865-35-5C18H21ClN2OS
N-(3,4-Dichlorobenzyl)-4-(morpholin-4-yl)aniline chemical structure, C17H18Cl2N2O, CAS 718602-71-2
N-(3,4-Dichlorobenzyl)-4-(morpholin-4-yl)aniline
CAS 718602-71-2C17H18Cl2N2O
N-(2-Fluorobenzyl)-4-(morpholin-4-yl)aniline chemical structure, C17H19FN2O, CAS 717864-78-3
N-(2-Fluorobenzyl)-4-(morpholin-4-yl)aniline
CAS 717864-78-3C17H19FN2O
N-[(2-Methylphenyl)methyl]-4-morpholin-4-ylaniline chemical structure, C18H22N2O, CAS 713507-97-2
N-[(2-Methylphenyl)methyl]-4-morpholin-4-ylaniline
CAS 713507-97-2C18H22N2O
3-Chloro-N-(4-methylbenzyl)-4-(4-morpholinyl)aniline chemical structure, C18H21ClN2O, CAS 362001-23-8
3-Chloro-N-(4-methylbenzyl)-4-(4-morpholinyl)aniline
CAS 362001-23-8C18H21ClN2O
N-[4-(Methylsulfanyl)benzyl]-4-(morpholin-4-yl)aniline chemical structure, C18H22N2OS, CAS 717892-72-3
N-[4-(Methylsulfanyl)benzyl]-4-(morpholin-4-yl)aniline
CAS 717892-72-3C18H22N2OS
(4-Methylbenzyl)(4-morpholin-4-ylphenyl)amine chemical structure, C18H22N2O, CAS 353489-79-9
(4-Methylbenzyl)(4-morpholin-4-ylphenyl)amine
CAS 353489-79-9C18H22N2O
N-[(4-Fluorophenyl)methyl]-4-morpholin-4-ylaniline chemical structure, C17H19FN2O, CAS 861443-07-4
N-[(4-Fluorophenyl)methyl]-4-morpholin-4-ylaniline
CAS 861443-07-4C17H19FN2O
(3-Bromo-4-ethoxy-5-methoxybenzyl)[4-(4-morpholinyl)phenyl]amine chemical structure, C20H25BrN2O3, CAS 717891-03-7
(3-Bromo-4-ethoxy-5-methoxybenzyl)[4-(4-morpholinyl)phenyl]amine
CAS 717891-03-7C20H25BrN2O3
N-(tert-Butyl)-2-(2-chloro-4-{[3-chloro-4-(4-morpholinyl)anilino]methyl}-6-methoxyphenoxy)acetamide chemical structure, C24H31Cl2N3O4, CAS 723751-85-7
N-(tert-Butyl)-2-(2-chloro-4-{[3-chloro-4-(4-morpholinyl)anilino]methyl}-6-methoxyphenoxy)acetamide
CAS 723751-85-7C24H31Cl2N3O4
N-[(5-Bromo-2-methoxyphenyl)methyl]-4-morpholin-4-ylaniline chemical structure, C18H21BrN2O2, CAS 401821-76-9
N-[(5-Bromo-2-methoxyphenyl)methyl]-4-morpholin-4-ylaniline
CAS 401821-76-9C18H21BrN2O2
5-[(3-Bromobenzyl)amino]-2-(morpholin-4-yl)benzoic acid chemical structure, C18H19BrN2O3, CAS 765933-69-5
5-[(3-Bromobenzyl)amino]-2-(morpholin-4-yl)benzoic acid
CAS 765933-69-5C18H19BrN2O3
5-[(2-Ethoxy-3-methoxybenzyl)amino]-2-(4-morpholinyl)benzoic acid chemical structure, C21H26N2O5, CAS 765933-90-2
5-[(2-Ethoxy-3-methoxybenzyl)amino]-2-(4-morpholinyl)benzoic acid
CAS 765933-90-2C21H26N2O5
5-[(2,4-Dimethoxybenzyl)amino]-2-(4-morpholinyl)benzoic acid chemical structure, C20H24N2O5, CAS 765934-01-8
5-[(2,4-Dimethoxybenzyl)amino]-2-(4-morpholinyl)benzoic acid
CAS 765934-01-8C20H24N2O5
5-[(3-Bromo-4,5-dimethoxybenzyl)amino]-2-(4-morpholinyl)benzoic acid chemical structure, C20H23BrN2O5, CAS 765933-98-0
5-[(3-Bromo-4,5-dimethoxybenzyl)amino]-2-(4-morpholinyl)benzoic acid
CAS 765933-98-0C20H23BrN2O5
5-(Benzylamino)-2-morpholin-4-ylbenzoic acid chemical structure, C18H20N2O3, CAS 765924-64-9
5-(Benzylamino)-2-morpholin-4-ylbenzoic acid
CAS 765924-64-9C18H20N2O3