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Murcko scaffold

N-Phenyl-4-(pyridin-2-yl)piperazine-1-carbothioamide scaffold

47 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
47
With full pages
26
Scaffold SMILES

S=C(Nc1ccccc1)N1CCN(c2ccccn2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-Phenyl-4-(pyridin-2-yl)piperazine-1-carbothioamide page
Murcko scaffold S=C(Nc1ccccc1)N1CCN(c2ccccn2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 47 of 47 chemicals

N-Phenyl-4-(pyridin-2-yl)piperazine-1-carbothioamide chemical structure, C16H18N4S, CAS 330865-56-0
N-Phenyl-4-(pyridin-2-yl)piperazine-1-carbothioamide
CAS 330865-56-0C16H18N4S
N-(4-Fluorophenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide chemical structure, C16H17FN4S, CAS 313381-12-3
N-(4-Fluorophenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide
CAS 313381-12-3C16H17FN4S
N-(2-Chlorophenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide chemical structure, C16H17ClN4S, CAS 406927-32-0
N-(2-Chlorophenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide
CAS 406927-32-0C16H17ClN4S
N-(3-Chlorophenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide chemical structure, C16H17ClN4S, CAS 431883-99-7
N-(3-Chlorophenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide
CAS 431883-99-7C16H17ClN4S
((4-Chlorophenyl)amino)(4-(2-pyridyl)piperazinyl)methane-1-thione chemical structure, C16H17ClN4S, CAS 431886-32-7
((4-Chlorophenyl)amino)(4-(2-pyridyl)piperazinyl)methane-1-thione
CAS 431886-32-7C16H17ClN4S
N-(4-Methoxyphenyl)-4-(pyridin-2-yl)piperazine-1-carbothioamide chemical structure, C17H20N4OS, CAS 431892-81-8
N-(4-Methoxyphenyl)-4-(pyridin-2-yl)piperazine-1-carbothioamide
CAS 431892-81-8C17H20N4OS
N-(3-Methylphenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide chemical structure, C17H20N4S, CAS 431916-21-1
N-(3-Methylphenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide
CAS 431916-21-1C17H20N4S
N-(2-Fluorophenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide chemical structure, C16H17FN4S, CAS 431070-12-1
N-(2-Fluorophenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide
CAS 431070-12-1C16H17FN4S
N-(3-Chloro-2-methylphenyl)-4-(2-pyridinyl)-1-piperazinecarbothioamide chemical structure, C17H19ClN4S, CAS 664969-00-0
N-(3-Chloro-2-methylphenyl)-4-(2-pyridinyl)-1-piperazinecarbothioamide
CAS 664969-00-0C17H19ClN4S
N-(2,4-Dimethylphenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide chemical structure, C18H22N4S, CAS 664969-41-9
N-(2,4-Dimethylphenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide
CAS 664969-41-9C18H22N4S
N-(3-Fluorophenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide chemical structure, C16H17FN4S, CAS 690699-39-9
N-(3-Fluorophenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide
CAS 690699-39-9C16H17FN4S
N-(3-Methoxyphenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide chemical structure, C17H20N4OS, CAS 473427-64-4
N-(3-Methoxyphenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide
CAS 473427-64-4C17H20N4OS
N-(2-Methoxyphenyl)-4-(pyridin-2-yl)piperazine-1-carbothioamide chemical structure, C17H20N4OS, CAS 380336-95-8
N-(2-Methoxyphenyl)-4-(pyridin-2-yl)piperazine-1-carbothioamide
CAS 380336-95-8C17H20N4OS
N-(3-Acetylphenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide chemical structure, C18H20N4OS, CAS 708234-38-2
N-(3-Acetylphenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide
CAS 708234-38-2C18H20N4OS
N-(3,4-Dimethylphenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide chemical structure, C18H22N4S, CAS 708282-62-6
N-(3,4-Dimethylphenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide
CAS 708282-62-6C18H22N4S
N-[3-(Difluoromethoxy)phenyl]-4-(2-pyridinyl)-1-piperazinecarbothioamide chemical structure, C17H18F2N4OS, CAS 488705-98-2
N-[3-(Difluoromethoxy)phenyl]-4-(2-pyridinyl)-1-piperazinecarbothioamide
CAS 488705-98-2C17H18F2N4OS
N-(4-Chloro-2,5-dimethoxyphenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide chemical structure, C18H21ClN4O2S, CAS 664968-57-4
N-(4-Chloro-2,5-dimethoxyphenyl)-4-pyridin-2-ylpiperazine-1-carbothioamide
CAS 664968-57-4C18H21ClN4O2S
N-(3,5-Dimethoxyphenyl)-4-(2-pyridinyl)-1-piperazinecarbothioamide chemical structure, C18H22N4O2S, CAS 664969-03-3
N-(3,5-Dimethoxyphenyl)-4-(2-pyridinyl)-1-piperazinecarbothioamide
CAS 664969-03-3C18H22N4O2S
N-(3-Chloro-4-fluorophenyl)-4-(2-pyridinyl)-1-piperazinecarbothioamide chemical structure, C16H16ClFN4S, CAS 519015-84-0
N-(3-Chloro-4-fluorophenyl)-4-(2-pyridinyl)-1-piperazinecarbothioamide
CAS 519015-84-0C16H16ClFN4S
Dimethyl 2-(4-(pyridin-2-yl)piperazine-1-carbothioamido)terephthalate chemical structure, C20H22N4O4S, CAS 717831-67-9
Dimethyl 2-(4-(pyridin-2-yl)piperazine-1-carbothioamido)terephthalate
CAS 717831-67-9C20H22N4O4S
Methyl 4,5-dimethoxy-2-(4-(pyridin-2-yl)piperazine-1-carbothioamido)benzoate chemical structure, C20H24N4O4S, CAS 717832-31-0
Methyl 4,5-dimethoxy-2-(4-(pyridin-2-yl)piperazine-1-carbothioamido)benzoate
CAS 717832-31-0C20H24N4O4S
Methyl 2-[4-[(4-pyridin-2-ylpiperazine-1-carbothioyl)amino]phenyl]acetate chemical structure, C19H22N4O2S, CAS 516458-51-8
Methyl 2-[4-[(4-pyridin-2-ylpiperazine-1-carbothioyl)amino]phenyl]acetate
CAS 516458-51-8C19H22N4O2S
4-Pyridin-2-yl-N-[2-(trifluoromethyl)phenyl]piperazine-1-carbothioamide chemical structure, C17H17F3N4S, CAS 708228-25-5
4-Pyridin-2-yl-N-[2-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
CAS 708228-25-5C17H17F3N4S
4-Pyridin-2-yl-N-(4-sulfamoylphenyl)piperazine-1-carbothioamide chemical structure, C16H19N5O2S2, CAS 664969-53-3
4-Pyridin-2-yl-N-(4-sulfamoylphenyl)piperazine-1-carbothioamide
CAS 664969-53-3C16H19N5O2S2