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Murcko scaffold

1-Phenyl-2-(4-phenylpiperazino)-1-ethanone scaffold

34 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
34
With full pages
13
Scaffold SMILES

O=C(CN1CCN(c2ccccc2)CC1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenyl-2-(4-phenylpiperazino)-1-ethanone page
Murcko scaffold O=C(CN1CCN(c2ccccc2)CC1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 34 of 34 chemicals

Acetophenone, 2-(4-(o-methoxyphenyl)piperazinyl)-3',4',5'-trimethoxy- chemical structure, C22H28N2O5, CAS 16785-20-9
Acetophenone, 2-(4-(o-methoxyphenyl)piperazinyl)-3',4',5'-trimethoxy-
CAS 16785-20-9C22H28N2O5
1-(4-Fluorophenyl)-2-(4-(2-methoxyphenyl)-1-piperazinyl)ethanone chemical structure, C19H21FN2O2, CAS 17135-52-3
1-(4-Fluorophenyl)-2-(4-(2-methoxyphenyl)-1-piperazinyl)ethanone
CAS 17135-52-3C19H21FN2O2
Acetophenone, 2-(4-(o-chlorophenyl)piperazinyl)-3',4',5'-trimethoxy- chemical structure, C21H25ClN2O4, CAS 17755-62-3
Acetophenone, 2-(4-(o-chlorophenyl)piperazinyl)-3',4',5'-trimethoxy-
CAS 17755-62-3C21H25ClN2O4
Acetophenone, 2-(4-(p-methoxyphenyl)piperazinyl)-3',4',5'-trimethoxy- chemical structure, C22H28N2O5, CAS 17755-64-5
Acetophenone, 2-(4-(p-methoxyphenyl)piperazinyl)-3',4',5'-trimethoxy-
CAS 17755-64-5C22H28N2O5
Ethanone, 2-(4-(3-chlorophenyl)-1-piperazinyl)-1-(4-(methylsulfonyl)phenyl)- chemical structure, C19H21ClN2O3S, CAS 56621-58-0
Ethanone, 2-(4-(3-chlorophenyl)-1-piperazinyl)-1-(4-(methylsulfonyl)phenyl)-
CAS 56621-58-0C19H21ClN2O3S
1-(3,4-Dihydroxyphenyl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethan-1-one chemical structure, C19H22N2O4, CAS 15532-98-6
1-(3,4-Dihydroxyphenyl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethan-1-one
CAS 15532-98-6C19H22N2O4
1-(4-Chlorophenyl)-2-(4-phenylpiperazin-1-yl)ethanone chemical structure, C18H19ClN2O, CAS 93994-39-9
1-(4-Chlorophenyl)-2-(4-phenylpiperazin-1-yl)ethanone
CAS 93994-39-9C18H19ClN2O
1-Phenyl-2-(4-phenylpiperazino)-1-ethanone chemical structure, C18H20N2O, CAS 97888-63-6
1-Phenyl-2-(4-phenylpiperazino)-1-ethanone
CAS 97888-63-6C18H20N2O
1-(4-Fluorophenyl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone chemical structure, C19H21FN2O2, CAS 483351-61-7
1-(4-Fluorophenyl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone
CAS 483351-61-7C19H21FN2O2
2-(4-(4-Methoxyphenyl)-1-piperazinyl)-1-phenylethanone chemical structure, C19H22N2O2, CAS 338396-68-2
2-(4-(4-Methoxyphenyl)-1-piperazinyl)-1-phenylethanone
CAS 338396-68-2C19H22N2O2
1-(4-Chlorophenyl)-2-[4-(2-fluorophenyl)piperazin-1-yl]ethanone chemical structure, C18H18ClFN2O, CAS 609791-78-8
1-(4-Chlorophenyl)-2-[4-(2-fluorophenyl)piperazin-1-yl]ethanone
CAS 609791-78-8C18H18ClFN2O
2-(4-(4-Chlorophenyl)-1-piperazinyl)-1-phenylethanone chemical structure, C18H19ClN2O, CAS 250713-99-6
2-(4-(4-Chlorophenyl)-1-piperazinyl)-1-phenylethanone
CAS 250713-99-6C18H19ClN2O
2-[4-(3-Chlorophenyl)piperazino]-1-phenyl-1-ethanone chemical structure, C18H19ClN2O, CAS 250714-00-2
2-[4-(3-Chlorophenyl)piperazino]-1-phenyl-1-ethanone
CAS 250714-00-2C18H19ClN2O
4-[2-(4-Phenylpiperazin-1-yl)acetyl]benzonitrile chemical structure, C19H19N3O, CAS 380491-75-8
4-[2-(4-Phenylpiperazin-1-yl)acetyl]benzonitrile
CAS 380491-75-8C19H19N3O
Methyl 4-{4-[2-(4-fluorophenyl)-2-oxoethyl]piperazino}-3-nitrobenzenecarboxylate chemical structure, C20H20FN3O5, CAS 341967-71-3
Methyl 4-{4-[2-(4-fluorophenyl)-2-oxoethyl]piperazino}-3-nitrobenzenecarboxylate
CAS 341967-71-3C20H20FN3O5
Methyl 3-nitro-4-{4-[2-(3-nitrophenyl)-2-oxoethyl]piperazino}benzenecarboxylate chemical structure, C20H20N4O7, CAS 341967-73-5
Methyl 3-nitro-4-{4-[2-(3-nitrophenyl)-2-oxoethyl]piperazino}benzenecarboxylate
CAS 341967-73-5C20H20N4O7
Methyl 4-{4-[2-(4-methylphenyl)-2-oxoethyl]piperazino}-3-nitrobenzenecarboxylate chemical structure, C21H23N3O5, CAS 341967-74-6
Methyl 4-{4-[2-(4-methylphenyl)-2-oxoethyl]piperazino}-3-nitrobenzenecarboxylate
CAS 341967-74-6C21H23N3O5
2-(4-(4-Nitrophenyl)piperazin-1-yl)-1-phenylethanone chemical structure, C18H19N3O3, CAS 457940-99-7
2-(4-(4-Nitrophenyl)piperazin-1-yl)-1-phenylethanone
CAS 457940-99-7C18H19N3O3
1-(4-Chlorophenyl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone chemical structure, C19H21ClN2O2, CAS 487034-04-8
1-(4-Chlorophenyl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone
CAS 487034-04-8C19H21ClN2O2
Ethyl 2-{2-[4-(4-methoxyphenyl)piperazino]acetyl}benzenecarboxylate chemical structure, C22H26N2O4, CAS 400085-14-5
Ethyl 2-{2-[4-(4-methoxyphenyl)piperazino]acetyl}benzenecarboxylate
CAS 400085-14-5C22H26N2O4
Methyl 4-{4-[2-(4-bromophenyl)-2-oxoethyl]piperazino}-3-nitrobenzenecarboxylate chemical structure, C20H20BrN3O5, CAS 478246-67-2
Methyl 4-{4-[2-(4-bromophenyl)-2-oxoethyl]piperazino}-3-nitrobenzenecarboxylate
CAS 478246-67-2C20H20BrN3O5
Mesylphenacyrazine chemical structure, C23H26N2O7S, CAS 50648-51-6
Mesylphenacyrazine
CAS 50648-51-6C23H26N2O7S
Benzenesulfonamide, N,N-dimethyl-4-((4-phenyl-1-piperazinyl)acetyl)-, (Z)-2-butenedioate (1:1) chemical structure, C24H29N3O7S, CAS 58722-49-9
Benzenesulfonamide, N,N-dimethyl-4-((4-phenyl-1-piperazinyl)acetyl)-, (Z)-2-butenedioate (1:1)
CAS 58722-49-9C24H29N3O7S
Benzenesulfonamide, N,N-diethyl-4-((4-phenyl-1-piperazinyl)acetyl)-, (Z)-2-butenedioate (1:1) chemical structure, C26H33N3O7S, CAS 58722-51-3
Benzenesulfonamide, N,N-diethyl-4-((4-phenyl-1-piperazinyl)acetyl)-, (Z)-2-butenedioate (1:1)
CAS 58722-51-3C26H33N3O7S