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Murcko scaffold

2-Phenyl-1-(4-phenylpiperazin-1-yl)ethanone scaffold

69 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
69
With full pages
28
Scaffold SMILES

O=C(Cc1ccccc1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Phenyl-1-(4-phenylpiperazin-1-yl)ethanone page
Murcko scaffold O=C(Cc1ccccc1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 69 chemicals

1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-(2-methoxyphenyl)ethanone chemical structure, C19H21ClN2O2, CAS 328284-40-8
1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-(2-methoxyphenyl)ethanone
CAS 328284-40-8C19H21ClN2O2
1-(4-Fluorophenyl)-4-[(2-methoxyphenyl)acetyl]piperazine chemical structure, C19H21FN2O2, CAS 328284-41-9
1-(4-Fluorophenyl)-4-[(2-methoxyphenyl)acetyl]piperazine
CAS 328284-41-9C19H21FN2O2
1-(4-Fluorophenyl)-4-[(4-methoxyphenyl)acetyl]piperazine chemical structure, C19H21FN2O2, CAS 349093-71-6
1-(4-Fluorophenyl)-4-[(4-methoxyphenyl)acetyl]piperazine
CAS 349093-71-6C19H21FN2O2
1-(4-(3-Chlorophenyl)piperazin-1-yl)-2-(4-methoxyphenyl)ethanone chemical structure, C19H21ClN2O2, CAS 349093-70-5
1-(4-(3-Chlorophenyl)piperazin-1-yl)-2-(4-methoxyphenyl)ethanone
CAS 349093-70-5C19H21ClN2O2
Ethanone, 2-(4-methoxyphenyl)-1-(4-phenyl-1-piperazinyl)- chemical structure, C19H22N2O2, CAS 314284-28-1
Ethanone, 2-(4-methoxyphenyl)-1-(4-phenyl-1-piperazinyl)-
CAS 314284-28-1C19H22N2O2
2-(3,4-Dimethoxyphenyl)-1-(4-phenylpiperazin-1-yl)ethanone chemical structure, C20H24N2O3, CAS 346698-76-8
2-(3,4-Dimethoxyphenyl)-1-(4-phenylpiperazin-1-yl)ethanone
CAS 346698-76-8C20H24N2O3
2-(2-Methoxyphenyl)-1-(4-phenylpiperazin-1-yl)ethanone chemical structure, C19H22N2O2, CAS 328284-42-0
2-(2-Methoxyphenyl)-1-(4-phenylpiperazin-1-yl)ethanone
CAS 328284-42-0C19H22N2O2
2-(4-Fluorophenyl)-1-[4-(4-fluorophenyl)piperazin-1-yl]ethanone chemical structure, C18H18F2N2O, CAS 432534-46-8
2-(4-Fluorophenyl)-1-[4-(4-fluorophenyl)piperazin-1-yl]ethanone
CAS 432534-46-8C18H18F2N2O
2-(4-Fluorophenyl)-1-[4-(2-fluorophenyl)piperazin-1-yl]ethanone chemical structure, C18H18F2N2O, CAS 433234-76-5
2-(4-Fluorophenyl)-1-[4-(2-fluorophenyl)piperazin-1-yl]ethanone
CAS 433234-76-5C18H18F2N2O
2-(2,6-Dichlorophenyl)-1-(4-phenylpiperazin-1-yl)ethanone chemical structure, C18H18Cl2N2O, CAS 438211-85-9
2-(2,6-Dichlorophenyl)-1-(4-phenylpiperazin-1-yl)ethanone
CAS 438211-85-9C18H18Cl2N2O
2-(4-Chlorophenyl)-1-(4-phenylpiperazin-1-yl)ethanone chemical structure, C18H19ClN2O, CAS 349416-37-1
2-(4-Chlorophenyl)-1-(4-phenylpiperazin-1-yl)ethanone
CAS 349416-37-1C18H19ClN2O
2-(4-Chlorophenyl)-1-[4-(2-methoxyphenyl)piperazin-1-yl]ethanone chemical structure, C19H21ClN2O2, CAS 349429-96-5
2-(4-Chlorophenyl)-1-[4-(2-methoxyphenyl)piperazin-1-yl]ethanone
CAS 349429-96-5C19H21ClN2O2
1-[4-(4-Fluorophenyl)piperazin-1-yl]-2-(2-nitrophenyl)ethanone chemical structure, C18H18FN3O3, CAS 349399-37-7
1-[4-(4-Fluorophenyl)piperazin-1-yl]-2-(2-nitrophenyl)ethanone
CAS 349399-37-7C18H18FN3O3
1-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-(4-methylphenyl)ethanone chemical structure, C20H24N2O2, CAS 599162-75-1
1-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-(4-methylphenyl)ethanone
CAS 599162-75-1C20H24N2O2
1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-(4-methylphenyl)ethanone chemical structure, C19H21ClN2O, CAS 599161-74-7
1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-(4-methylphenyl)ethanone
CAS 599161-74-7C19H21ClN2O
1-[4-(2,3-Dimethylphenyl)piperazin-1-yl]-2-(4-methylphenyl)ethanone chemical structure, C21H26N2O, CAS 599163-11-8
1-[4-(2,3-Dimethylphenyl)piperazin-1-yl]-2-(4-methylphenyl)ethanone
CAS 599163-11-8C21H26N2O
1-[4-(2-Fluorophenyl)piperazin-1-yl]-2-(4-methylphenyl)ethanone chemical structure, C19H21FN2O, CAS 599163-25-4
1-[4-(2-Fluorophenyl)piperazin-1-yl]-2-(4-methylphenyl)ethanone
CAS 599163-25-4C19H21FN2O
2-(4-Chlorophenyl)-1-[4-(4-chlorophenyl)piperazin-1-yl]ethanone chemical structure, C18H18Cl2N2O, CAS 438475-86-6
2-(4-Chlorophenyl)-1-[4-(4-chlorophenyl)piperazin-1-yl]ethanone
CAS 438475-86-6C18H18Cl2N2O
Piperazine, 1-(4-chlorophenyl)-4-(phenylacetyl)- chemical structure, C18H19ClN2O, CAS 89007-34-1
Piperazine, 1-(4-chlorophenyl)-4-(phenylacetyl)-
CAS 89007-34-1C18H19ClN2O
1-(4-(2-Methoxyphenyl)piperazin-1-yl)-2-phenylethanone chemical structure, C19H22N2O2, CAS 349093-44-3
1-(4-(2-Methoxyphenyl)piperazin-1-yl)-2-phenylethanone
CAS 349093-44-3C19H22N2O2
1-[4-(2-Fluorophenyl)piperazin-1-yl]-2-phenylethanone chemical structure, C18H19FN2O, CAS 546069-01-6
1-[4-(2-Fluorophenyl)piperazin-1-yl]-2-phenylethanone
CAS 546069-01-6C18H19FN2O
2-(4-Chlorophenyl)-1-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone chemical structure, C19H21ClN2O2, CAS 694499-74-6
2-(4-Chlorophenyl)-1-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone
CAS 694499-74-6C19H21ClN2O2
1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-(3,4-dimethoxyphenyl)ethanone chemical structure, C20H23ClN2O3, CAS 346700-02-5
1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-(3,4-dimethoxyphenyl)ethanone
CAS 346700-02-5C20H23ClN2O3
1-[4-(2-Fluorophenyl)piperazin-1-yl]-2-(2-nitrophenyl)ethanone chemical structure, C18H18FN3O3, CAS 667408-37-9
1-[4-(2-Fluorophenyl)piperazin-1-yl]-2-(2-nitrophenyl)ethanone
CAS 667408-37-9C18H18FN3O3