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Murcko scaffold

3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-phenylpropanamide scaffold

26 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
26
With full pages
10
Scaffold SMILES

O=C(CCN1CCc2ccccc2C1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-phenylpropanamide page
Murcko scaffold O=C(CCN1CCc2ccccc2C1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(4-methylphenyl)propanamide chemical structure, C19H22N2O, CAS 428839-17-2
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(4-methylphenyl)propanamide
CAS 428839-17-2C19H22N2O
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2-methoxyphenyl)propanamide chemical structure, C19H22N2O2, CAS 329209-49-6
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2-methoxyphenyl)propanamide
CAS 329209-49-6C19H22N2O2
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2,5-dimethylphenyl)propanamide chemical structure, C20H24N2O, CAS 428835-66-9
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2,5-dimethylphenyl)propanamide
CAS 428835-66-9C20H24N2O
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(3-methoxyphenyl)propanamide chemical structure, C19H22N2O2, CAS 428850-40-2
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(3-methoxyphenyl)propanamide
CAS 428850-40-2C19H22N2O2
N-(2-Chlorophenyl)-3-(3,4-dihydro-1H-isoquinolin-2-yl)propanamide chemical structure, C18H19ClN2O, CAS 428829-30-5
N-(2-Chlorophenyl)-3-(3,4-dihydro-1H-isoquinolin-2-yl)propanamide
CAS 428829-30-5C18H19ClN2O
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-N-(4-methoxyphenyl)propanamide chemical structure, C19H22N2O2, CAS 428853-17-2
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-N-(4-methoxyphenyl)propanamide
CAS 428853-17-2C19H22N2O2
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2-fluorophenyl)propanamide chemical structure, C18H19FN2O, CAS 333758-97-7
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2-fluorophenyl)propanamide
CAS 333758-97-7C18H19FN2O
N-(4-Chlorophenyl)-3-(3,4-dihydro-1H-isoquinolin-2-yl)propanamide chemical structure, C18H19ClN2O, CAS 428850-58-2
N-(4-Chlorophenyl)-3-(3,4-dihydro-1H-isoquinolin-2-yl)propanamide
CAS 428850-58-2C18H19ClN2O
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(4-fluorophenyl)propanamide chemical structure, C18H19FN2O, CAS 333758-83-1
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(4-fluorophenyl)propanamide
CAS 333758-83-1C18H19FN2O
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(3-fluorophenyl)propanamide chemical structure, C18H19FN2O, CAS 333759-05-0
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(3-fluorophenyl)propanamide
CAS 333759-05-0C18H19FN2O
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2-methoxy-5-methylphenyl)propanamide chemical structure, C20H24N2O2, CAS 429625-57-0
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2-methoxy-5-methylphenyl)propanamide
CAS 429625-57-0C20H24N2O2
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(3-methylphenyl)propanamide chemical structure, C19H22N2O, CAS 461407-43-2
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(3-methylphenyl)propanamide
CAS 461407-43-2C19H22N2O
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-phenylpropanamide chemical structure, C18H20N2O, CAS 498535-29-8
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-phenylpropanamide
CAS 498535-29-8C18H20N2O
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2,5-dimethoxyphenyl)propanamide chemical structure, C20H24N2O3, CAS 428839-14-9
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2,5-dimethoxyphenyl)propanamide
CAS 428839-14-9C20H24N2O3
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2-methylphenyl)propanamide chemical structure, C19H22N2O, CAS 429623-85-8
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2-methylphenyl)propanamide
CAS 429623-85-8C19H22N2O
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(3,5-dimethoxyphenyl)propanamide chemical structure, C20H24N2O3, CAS 489397-77-5
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(3,5-dimethoxyphenyl)propanamide
CAS 489397-77-5C20H24N2O3
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2,4-dimethoxyphenyl)propanamide chemical structure, C20H24N2O3, CAS 428837-89-2
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2,4-dimethoxyphenyl)propanamide
CAS 428837-89-2C20H24N2O3
N-(3-Chlorophenyl)-3-(3,4-dihydro-1H-isoquinolin-2-yl)propanamide chemical structure, C18H19ClN2O, CAS 428832-32-0
N-(3-Chlorophenyl)-3-(3,4-dihydro-1H-isoquinolin-2-yl)propanamide
CAS 428832-32-0C18H19ClN2O
N-(4-Bromophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide chemical structure, C18H19BrN2O, CAS 429620-28-0
N-(4-Bromophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
CAS 429620-28-0C18H19BrN2O
N-(4-Bromo-3-methylphenyl)-3-(3,4-dihydro-1H-isoquinolin-2-yl)propanamide chemical structure, C19H21BrN2O, CAS 428823-90-9
N-(4-Bromo-3-methylphenyl)-3-(3,4-dihydro-1H-isoquinolin-2-yl)propanamide
CAS 428823-90-9C19H21BrN2O
N-(3,4-Dichlorophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide chemical structure, C18H18Cl2N2O, CAS 730957-25-2
N-(3,4-Dichlorophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
CAS 730957-25-2C18H18Cl2N2O
N-(4-Bromo-3-methylphenyl)-3-(3,4-dihydro-1H-isoquinolin-2-yl)propanamide, hydrochloride chemical structure, C19H22BrClN2O, CAS 1052405-09-0
N-(4-Bromo-3-methylphenyl)-3-(3,4-dihydro-1H-isoquinolin-2-yl)propanamide, hydrochloride
CAS 1052405-09-0C19H22BrClN2O
N-(3-Chloro-2-methylphenyl)-3-(3,4-dihydro-1H-isoquinolin-2-yl)propanamide chemical structure, C19H21ClN2O, CAS 428839-69-4
N-(3-Chloro-2-methylphenyl)-3-(3,4-dihydro-1H-isoquinolin-2-yl)propanamide
CAS 428839-69-4C19H21ClN2O
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2-methoxy-5-methylphenyl)propanamide, hydrochloride chemical structure, C20H25ClN2O2, CAS 1049789-93-6
3-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2-methoxy-5-methylphenyl)propanamide, hydrochloride
CAS 1049789-93-6C20H25ClN2O2