Murcko scaffold
2-[(4-Oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]-N-phenylacetamide scaffold
59 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 22
- Chemicals
- 59
- With full pages
- 13
Scaffold SMILES
O=C(CSc1nc2ccccc2c(=O)[nH]1)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=C(CSc1nc2ccccc2c(=O)[nH]1)Nc1ccccc1](/scaffold/KDRIURZVJMYZNJ-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 59 chemicals
2-(3-Methyl-4-oxoquinazolin-2-yl)sulfanyl-N-(2-propan-2-yloxyphenyl)acetamide
CAS 309279-28-5C20H21N3O3S
2-(3-Amino-4-oxoquinazolin-2-yl)sulfanyl-N-(2-fluorophenyl)acetamide
CAS 540515-19-3C16H13FN4O2S
![N-(2,4-Difluorophenyl)-2-{[3-(2-methylpropyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide chemical structure, C20H19F2N3O2S, CAS 255865-21-5](/s/ZULLDQLIZVTLAU-UHFFFAOYSA-N.svg)
N-(2,4-Difluorophenyl)-2-{[3-(2-methylpropyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide
CAS 255865-21-5C20H19F2N3O2S
![N-(2-Bromophenyl)-2-[(3-ethyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]acetamide chemical structure, C18H16BrN3O2S, CAS 329929-13-7](/s/FKNOIZFITNRALB-UHFFFAOYSA-N.svg)
N-(2-Bromophenyl)-2-[(3-ethyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]acetamide
CAS 329929-13-7C18H16BrN3O2S
![2-[(3-Ethyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]-N-(4-fluorophenyl)acetamide chemical structure, C18H16FN3O2S, CAS 329929-16-0](/s/RBTUJGRBLKYPKE-UHFFFAOYSA-N.svg)
2-[(3-Ethyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]-N-(4-fluorophenyl)acetamide
CAS 329929-16-0C18H16FN3O2S
![N-(2,3-Dichlorophenyl)-2-[(3-ethyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]acetamide chemical structure, C18H15Cl2N3O2S, CAS 329079-81-4](/s/NTRPXOTYIOBSMM-UHFFFAOYSA-N.svg)
N-(2,3-Dichlorophenyl)-2-[(3-ethyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]acetamide
CAS 329079-81-4C18H15Cl2N3O2S
![2-{[4-Oxo-3-(prop-2-en-1-yl)-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-phenyl-N-(propan-2-yl)acetamide chemical structure, C22H23N3O2S, CAS 313395-96-9](/s/HUQDTBSIDBRMSD-UHFFFAOYSA-N.svg)
2-{[4-Oxo-3-(prop-2-en-1-yl)-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-phenyl-N-(propan-2-yl)acetamide
CAS 313395-96-9C22H23N3O2S
2-(3-Ethyl-4-oxoquinazolin-2-yl)sulfanyl-N-(2-methylphenyl)acetamide
CAS 557070-15-2C19H19N3O2S
![N-(4-Fluorophenyl)-2-{[3-(2-methylpropyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide chemical structure, C20H20FN3O2S, CAS 255865-19-1](/s/ALVDUVWVGNMPRU-UHFFFAOYSA-N.svg)
N-(4-Fluorophenyl)-2-{[3-(2-methylpropyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide
CAS 255865-19-1C20H20FN3O2S
![N-(4-Methylphenyl)-2-{[4-oxo-3-(prop-2-en-1-yl)-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide chemical structure, C20H19N3O2S, CAS 525582-57-4](/s/JPXOTBSMZXCLLC-UHFFFAOYSA-N.svg)
N-(4-Methylphenyl)-2-{[4-oxo-3-(prop-2-en-1-yl)-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide
CAS 525582-57-4C20H19N3O2S
2-((3-Allyl-4-oxo-3,4-dihydroquinazolin-2-yl)thio)-N-(4-methoxyphenyl)acetamide
CAS 302583-57-9C20H19N3O3S
![N-(3,4-Dichlorophenyl)-2-{[4-oxo-3-(prop-2-en-1-yl)-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide chemical structure, C19H15Cl2N3O2S, CAS 525582-58-5](/s/ZNRJVUFUMCUIDV-UHFFFAOYSA-N.svg)
N-(3,4-Dichlorophenyl)-2-{[4-oxo-3-(prop-2-en-1-yl)-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide
CAS 525582-58-5C19H15Cl2N3O2S
![2-[(3-Ethyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide chemical structure, C19H19N3O3S, CAS 256955-22-3](/s/KDMVGVDADHTJAV-UHFFFAOYSA-N.svg)
2-[(3-Ethyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide
CAS 256955-22-3C19H19N3O3S
![2-{[3-(2-Methylpropyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-(3-nitrophenyl)acetamide chemical structure, C20H20N4O4S, CAS 329079-87-0](/s/QPGILSXEKPZYHZ-UHFFFAOYSA-N.svg)
2-{[3-(2-Methylpropyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-(3-nitrophenyl)acetamide
CAS 329079-87-0C20H20N4O4S
![2-{[3-(2-Methylpropyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C21H20F3N3O2S, CAS 255865-22-6](/s/SPWJUFWCDVWASK-UHFFFAOYSA-N.svg)
2-{[3-(2-Methylpropyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 255865-22-6C21H20F3N3O2S
2-(3-Ethyl-6-iodo-4-oxoquinazolin-2-yl)sulfanyl-N-(2-methylphenyl)acetamide
CAS 497076-26-3C19H18IN3O2S
2-(3-Ethyl-6,7-dimethoxy-4-oxoquinazolin-2-yl)sulfanyl-N-phenylacetamide
CAS 517869-44-2C20H21N3O4S
N-(4-Chloro-2-methylphenyl)-2-(4-oxo-3-prop-2-enylquinazolin-2-yl)sulfanylacetamide
CAS 525582-59-6C20H18ClN3O2S
![N-(4-Bromophenyl)-2-[(3-ethyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]acetamide chemical structure, C18H16BrN3O2S, CAS 525582-56-3](/s/XSCLSHCIRIXUGQ-UHFFFAOYSA-N.svg)
N-(4-Bromophenyl)-2-[(3-ethyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]acetamide
CAS 525582-56-3C18H16BrN3O2S
![2-[(3-Ethyl-6,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]-N-(4-methylphenyl)acetamide chemical structure, C21H23N3O4S, CAS 525581-55-9](/s/ZFGQAHQXSMRMJY-UHFFFAOYSA-N.svg)
2-[(3-Ethyl-6,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]-N-(4-methylphenyl)acetamide
CAS 525581-55-9C21H23N3O4S
![2-[6-Iodo-3-(2-methylprop-2-enyl)-4-oxoquinazolin-2-yl]sulfanyl-N-(2-methylphenyl)acetamide chemical structure, C21H20IN3O2S, CAS 714280-69-0](/s/XIBNHTCHTMYMHN-UHFFFAOYSA-N.svg)
2-[6-Iodo-3-(2-methylprop-2-enyl)-4-oxoquinazolin-2-yl]sulfanyl-N-(2-methylphenyl)acetamide
CAS 714280-69-0C21H20IN3O2S
2-(6-Iodo-4-oxo-3-prop-2-enylquinazolin-2-yl)sulfanyl-N-(2-methylphenyl)acetamide
CAS 488121-99-9C20H18IN3O2S
![2-[(3-Ethyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]-N-(4-ethylphenyl)acetamide chemical structure, C20H21N3O2S, CAS 525582-55-2](/s/XTVAICXCUDLAKZ-UHFFFAOYSA-N.svg)
2-[(3-Ethyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]-N-(4-ethylphenyl)acetamide
CAS 525582-55-2C20H21N3O2S
![2-[(3-Ethyl-6,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide chemical structure, C21H23N3O5S, CAS 517869-46-4](/s/HTYQXJVCDOETLO-UHFFFAOYSA-N.svg)
2-[(3-Ethyl-6,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide
CAS 517869-46-4C21H23N3O5S
- 2-(3-Ethyl-6-iodo-4-oxoquinazolin-2-yl)sulfanyl-N-(4-methylphenyl)acetamide701237-72-1C19H18IN3O2S
- N-(2,5-Dimethoxyphenyl)-2-(4-oxo-3-prop-2-enylquinazolin-2-yl)sulfanylacetamide701241-11-4C21H21N3O4S
- N-(2-Methoxyphenyl)-2-{[4-oxo-3-(prop-2-en-1-yl)-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide5169-72-2C20H19N3O3S
- N-(2,6-Dichlorophenyl)-2-(3-methyl-4-oxoquinazolin-2-yl)sulfanylacetamide805270-04-6C17H13Cl2N3O2S
- N-(4-Bromophenyl)-2-{[6,7-dimethoxy-4-oxo-3-(prop-2-en-1-yl)-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide525581-56-0C21H20BrN3O4S
- N-(4-Chlorophenyl)-2-[(3-ethyl-6,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]acetamide517869-45-3C20H20ClN3O4S
- Methyl 2-[2-(2-chloroanilino)-2-oxoethyl]sulfanyl-3-(2-methoxyethyl)-4-oxoquinazoline-7-carboxylate443349-42-6C21H20ClN3O5S
- N-(2-Chloro-5-nitrophenyl)-2-{[3-(1-methoxypropan-2-yl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}propanamide757226-43-0C21H21ClN4O5S
- 2-((3-(2-Acetamidoethyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)-N-(3-chloro-4-methylphenyl)acetamide443355-11-1C21H21ClN4O3S
- 2-[(3-Isobutyl-4-oxo-3,4-dihydro-2-quinazolinyl)sulfanyl]-N-[4-(trifluoromethoxy)phenyl]acetamide882083-32-1C21H20F3N3O3S
- 2-[(3-Ethyl-4-oxo-3,4-dihydro-2-quinazolinyl)sulfanyl]-N-[4-(trifluoromethoxy)phenyl]acetamide882083-37-6C19H16F3N3O3S
- Methyl 2-({[(4-ethoxyphenyl)carbamoyl]methyl}sulfanyl)-3-(2-methoxyethyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate422530-92-5C23H25N3O6S
- N-[3-Chloro-4-(difluoromethoxy)phenyl]-2-[(3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]acetamide832138-58-6C18H14ClF2N3O3S
- 2-[(3-Amino-4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]-N-[2-(difluoromethoxy)phenyl]acetamide832142-76-4C17H14F2N4O3S
- N-(4-Bromo-3-methylphenyl)-2-{[3-(2-methylpropyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetamide939746-11-9C21H22BrN3O2S
- N-(2-Cyanoethyl)-N-(3,5-dimethylphenyl)-2-[(4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]acetamide731796-39-7C21H20N4O2S
- N-(2,6-Dichlorophenyl)-2-((4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetamide569316-67-2C16H11Cl2N3O2S
- 2-[(4-Oxo-3,4-dihydro-2-quinazolinyl)sulfanyl]-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]acetamide1020252-65-6C18H13F4N3O3S
- N-(2-Hydroxyphenyl)-2-[(4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]acetamide876718-42-2C16H13N3O3S
- N-(2-Chlorophenyl)-2-[(4-oxo-1H-quinazolin-2-yl)sulfanyl]acetamide678559-94-9C16H12ClN3O2S
- 2-[(4-Oxo-1H-quinazolin-2-yl)sulfanyl]-N-[4-(trifluoromethylsulfanyl)phenyl]acetamide1022421-80-2C17H12F3N3O2S2
- N-(4-Acetylphenyl)-2-(4-oxo(3-hydroquinazolin-2-ylthio))propanamide1024414-31-0C19H17N3O3S
- N-[4-(Diethylamino)phenyl]-2-[(4-hydroxy-2-quinazolinyl)thio]acetamide561311-25-9C20H22N4O2S
- N-[3,5-Bis(trifluoromethyl)phenyl]-2-[(4-oxo-1H-quinazolin-2-yl)sulfanyl]acetamide556787-47-4C18H11F6N3O2S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(CSc1nc(=O)n2ccccc2n1)Nc1ccccc115 chemicals
O=C(CCNc1ccccc1)c1ccc2ccccc2c115 chemicals
O=C(COc1ccccc1)Nc1ccc2c(c1)OCCO215 chemicals
O=C(CCc1ccccc1)Nc1ccc2ccccc2c113 chemicals![Scaffold O=C(NCCc1cc2ccccc2[nH]c1=O)c1ccccc1](/scaffold/RLWQKKJAXJDFAZ-UHFFFAOYSA-N/structure.svg)
O=C(NCCc1cc2ccccc2[nH]c1=O)c1ccccc112 chemicals
O=C(CCN1CCc2ccccc2C1)Nc1ccccc110 chemicals
O=C(CSc1ccc2ccccc2n1)Nc1ccccc18 chemicals
O=C(CSC1=NS(=O)(=O)c2ccccc2N1)Nc1ccccc18 chemicals
O=C(CCn1cnc2ccccc2c1=O)Nc1ccccc18 chemicals
O=C(NCCc1ccccc1)c1cc2ccccc2oc1=O7 chemicals
O=C(NCCc1ccccc1)c1cc(=O)c2ccccc2o17 chemicals
O=C(CC1Sc2ccccc2NC1=O)NCc1ccccc17 chemicals