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Murcko scaffold

Ring system with 3 rings and 22 atoms

275 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
275
With full pages
12
Scaffold SMILES

O=C(NCCc1cc2ccccc2[nH]c1=O)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCCc1cc2ccccc2[nH]c1=O)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 275 chemicals

4-(Diethylsulfamoyl)-N-[2-(5,8-dimethoxy-2-oxo-1H-quinolin-3-yl)ethyl]benzamide chemical structure, C24H29N3O6S, CAS 851404-22-3
4-(Diethylsulfamoyl)-N-[2-(5,8-dimethoxy-2-oxo-1H-quinolin-3-yl)ethyl]benzamide
CAS 851404-22-3C24H29N3O6S
N-(2-(5,8-Dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)-4-(N,N-dimethylsulfamoyl)benzamide chemical structure, C22H25N3O6S, CAS 851404-21-2
N-(2-(5,8-Dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)-4-(N,N-dimethylsulfamoyl)benzamide
CAS 851404-21-2C22H25N3O6S
N-(2-(5,8-Dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)-2-fluorobenzamide chemical structure, C20H19FN2O4, CAS 851403-63-9
N-(2-(5,8-Dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)-2-fluorobenzamide
CAS 851403-63-9C20H19FN2O4
5-Bromo-2-chloro-N-[2-(7-methoxy-2-oxo-1H-quinolin-3-yl)ethyl]benzamide chemical structure, C19H16BrClN2O3, CAS 851405-58-8
5-Bromo-2-chloro-N-[2-(7-methoxy-2-oxo-1H-quinolin-3-yl)ethyl]benzamide
CAS 851405-58-8C19H16BrClN2O3
N-[2-(5,8-Dimethoxy-2-oxo-1H-quinolin-3-yl)ethyl]-3-nitrobenzamide chemical structure, C20H19N3O6, CAS 851403-46-8
N-[2-(5,8-Dimethoxy-2-oxo-1H-quinolin-3-yl)ethyl]-3-nitrobenzamide
CAS 851403-46-8C20H19N3O6
2-Chloro-N-[2-(7-methyl-2-oxo-1H-quinolin-3-yl)ethyl]benzamide chemical structure, C19H17ClN2O2, CAS 851404-45-0
2-Chloro-N-[2-(7-methyl-2-oxo-1H-quinolin-3-yl)ethyl]benzamide
CAS 851404-45-0C19H17ClN2O2
3,4-Diethoxy-N-(2-(7-methyl-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)benzamide chemical structure, C23H26N2O4, CAS 851404-76-7
3,4-Diethoxy-N-(2-(7-methyl-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)benzamide
CAS 851404-76-7C23H26N2O4
2-Methoxy-N-[2-(7-methoxy-2-oxo-1H-quinolin-3-yl)ethyl]benzamide chemical structure, C20H20N2O4, CAS 851405-78-2
2-Methoxy-N-[2-(7-methoxy-2-oxo-1H-quinolin-3-yl)ethyl]benzamide
CAS 851405-78-2C20H20N2O4
4-Chloro-N-(2-(5,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)benzamide chemical structure, C20H19ClN2O4, CAS 851403-87-7
4-Chloro-N-(2-(5,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)benzamide
CAS 851403-87-7C20H19ClN2O4
4-Chloro-N-(2-(7-methyl-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)-3-nitrobenzamide chemical structure, C19H16ClN3O4, CAS 851405-10-2
4-Chloro-N-(2-(7-methyl-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)-3-nitrobenzamide
CAS 851405-10-2C19H16ClN3O4
3,4,5-Trimethoxy-N-(2-(7-methyl-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)benzamide chemical structure, C22H24N2O5, CAS 851404-43-8
3,4,5-Trimethoxy-N-(2-(7-methyl-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)benzamide
CAS 851404-43-8C22H24N2O5
2-Chloro-N-[2-(5,8-dimethoxy-2-oxo-1H-quinolin-3-yl)ethyl]-6-fluorobenzamide chemical structure, C20H18ClFN2O4, CAS 851403-62-8
2-Chloro-N-[2-(5,8-dimethoxy-2-oxo-1H-quinolin-3-yl)ethyl]-6-fluorobenzamide
CAS 851403-62-8C20H18ClFN2O4
4-Chloro-N-[2-(5,8-dimethyl-2-oxo-1H-quinolin-3-yl)ethyl]-3-nitrobenzamide chemical structure, C20H18ClN3O4, CAS 851407-09-5
4-Chloro-N-[2-(5,8-dimethyl-2-oxo-1H-quinolin-3-yl)ethyl]-3-nitrobenzamide
CAS 851407-09-5C20H18ClN3O4
3-Methoxy-N-[2-(7-methoxy-2-oxo-1H-quinolin-3-yl)ethyl]benzamide chemical structure, C20H20N2O4, CAS 851405-81-7
3-Methoxy-N-[2-(7-methoxy-2-oxo-1H-quinolin-3-yl)ethyl]benzamide
CAS 851405-81-7C20H20N2O4
4-Chloro-N-[2-(7-methyl-2-oxo-1H-quinolin-3-yl)ethyl]benzamide chemical structure, C19H17ClN2O2, CAS 851404-91-6
4-Chloro-N-[2-(7-methyl-2-oxo-1H-quinolin-3-yl)ethyl]benzamide
CAS 851404-91-6C19H17ClN2O2
N-[2-(5,8-Dimethoxy-2-oxo-1H-quinolin-3-yl)ethyl]-4-(trifluoromethyl)benzamide chemical structure, C21H19F3N2O4, CAS 851404-34-7
N-[2-(5,8-Dimethoxy-2-oxo-1H-quinolin-3-yl)ethyl]-4-(trifluoromethyl)benzamide
CAS 851404-34-7C21H19F3N2O4
N-(2-(5,8-Dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)-2-methoxybenzamide chemical structure, C21H22N2O3, CAS 851406-77-4
N-(2-(5,8-Dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)-2-methoxybenzamide
CAS 851406-77-4C21H22N2O3
3-Chloro-N-(2-(5,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)benzamide chemical structure, C20H19ClN2O2, CAS 851406-74-1
3-Chloro-N-(2-(5,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)benzamide
CAS 851406-74-1C20H19ClN2O2
N-[2-(7-Methoxy-2-oxo-1H-quinolin-3-yl)ethyl]-4-methyl-3-nitrobenzamide chemical structure, C20H19N3O5, CAS 851406-06-9
N-[2-(7-Methoxy-2-oxo-1H-quinolin-3-yl)ethyl]-4-methyl-3-nitrobenzamide
CAS 851406-06-9C20H19N3O5
N-[2-(7-Methyl-2-oxo-1H-quinolin-3-yl)ethyl]-2-nitrobenzamide chemical structure, C19H17N3O4, CAS 851404-77-8
N-[2-(7-Methyl-2-oxo-1H-quinolin-3-yl)ethyl]-2-nitrobenzamide
CAS 851404-77-8C19H17N3O4
3-Fluoro-N-[2-(7-methyl-2-oxo-1H-quinolin-3-yl)ethyl]benzamide chemical structure, C19H17FN2O2, CAS 851404-67-6
3-Fluoro-N-[2-(7-methyl-2-oxo-1H-quinolin-3-yl)ethyl]benzamide
CAS 851404-67-6C19H17FN2O2
3-Methoxy-N-[2-(7-methyl-2-oxo-1H-quinolin-3-yl)ethyl]benzamide chemical structure, C20H20N2O3, CAS 851404-81-4
3-Methoxy-N-[2-(7-methyl-2-oxo-1H-quinolin-3-yl)ethyl]benzamide
CAS 851404-81-4C20H20N2O3
2-Chloro-6-fluoro-N-[2-(7-methoxy-2-oxo-1H-quinolin-3-yl)ethyl]benzamide chemical structure, C19H16ClFN2O3, CAS 851405-64-6
2-Chloro-6-fluoro-N-[2-(7-methoxy-2-oxo-1H-quinolin-3-yl)ethyl]benzamide
CAS 851405-64-6C19H16ClFN2O3
N-[2-(5,8-Dimethoxy-2-oxo-1H-quinolin-3-yl)ethyl]-3-(trifluoromethyl)benzamide chemical structure, C21H19F3N2O4, CAS 851403-64-0
N-[2-(5,8-Dimethoxy-2-oxo-1H-quinolin-3-yl)ethyl]-3-(trifluoromethyl)benzamide
CAS 851403-64-0C21H19F3N2O4