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Murcko scaffold

Ring system with 3 rings and 22 atoms

19 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 22
Chemicals: 19
With full pages: 7

Scaffold SMILES

O=C(NCCc1ccccc1)c1cc(=O)c2ccccc2o1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(NCCc1ccccc1)c1cc(=O)c2ccccc2o1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

6,8-Dimethyl-4-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-4H-chromene-2-carboxamide chemical structure, C20H20N2O5S, CAS 872867-71-5

6,8-Dimethyl-4-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-4H-chromene-2-carboxamide

CAS 872867-71-5C₂₀H₂₀N₂O₅S

4-Oxo-N-[2-(4-sulfamoylphenyl)ethyl]-4H-chromene-2-carboxamide chemical structure, C18H16N2O5S, CAS 377767-97-0

4-Oxo-N-[2-(4-sulfamoylphenyl)ethyl]-4H-chromene-2-carboxamide

CAS 377767-97-0C₁₈H₁₆N₂O₅S

N-[2-(4-Fluorophenyl)ethyl]-4-oxochromene-2-carboxamide chemical structure, C18H14FNO3, CAS 380469-78-3

N-[2-(4-Fluorophenyl)ethyl]-4-oxochromene-2-carboxamide

CAS 380469-78-3C₁₈H₁₄FNO₃

6-Ethyl-4-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-4H-chromene-2-carboxamide chemical structure, C20H20N2O5S, CAS 874355-66-5

6-Ethyl-4-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-4H-chromene-2-carboxamide

CAS 874355-66-5C₂₀H₂₀N₂O₅S

6-Methyl-4-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-4H-chromene-2-carboxamide chemical structure, C19H18N2O5S, CAS 881217-60-3

6-Methyl-4-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-4H-chromene-2-carboxamide

CAS 881217-60-3C₁₉H₁₈N₂O₅S

N-{2-[4-(Aminosulfonyl)phenyl]ethyl}-7,8-dimethyl-4-oxo-4H-chromene-2-carboxamide chemical structure, C20H20N2O5S, CAS 879564-30-4

N-{2-[4-(Aminosulfonyl)phenyl]ethyl}-7,8-dimethyl-4-oxo-4H-chromene-2-carboxamide

CAS 879564-30-4C₂₀H₂₀N₂O₅S

7-Methyl-4-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-4H-chromene-2-carboxamide chemical structure, C19H18N2O5S, CAS 879468-78-7

7-Methyl-4-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-4H-chromene-2-carboxamide

CAS 879468-78-7C₁₉H₁₈N₂O₅S

6-Chloro-4-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-4H-chromene-2-carboxamide chemical structure, C18H15ClN2O5S, CAS 880784-84-9

6-Chloro-4-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-4H-chromene-2-carboxamide

CAS 880784-84-9C₁₈H₁₅ClN₂O₅S

6,7-Dimethyl-4-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-4H-chromene-2-carboxamide chemical structure, C20H20N2O5S, CAS 873080-96-7

6,7-Dimethyl-4-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-4H-chromene-2-carboxamide

CAS 873080-96-7C₂₀H₂₀N₂O₅S

6-Chloro-N-[2-(3,4-dimethoxyphenyl)ethyl]-4-oxo-4H-chromene-2-carboxamide chemical structure, C20H18ClNO5, CAS 880400-69-1

6-Chloro-N-[2-(3,4-dimethoxyphenyl)ethyl]-4-oxo-4H-chromene-2-carboxamide

CAS 880400-69-1C₂₀H₁₈ClNO₅

N-[2-(4-Methoxyphenyl)ethyl]-6-methyl-4-oxochromene-2-carboxamide chemical structure, C20H19NO4, CAS 879358-44-8

N-[2-(4-Methoxyphenyl)ethyl]-6-methyl-4-oxochromene-2-carboxamide

CAS 879358-44-8C₂₀H₁₉NO₄

N-[2-(3,4-Dimethoxyphenyl)ethyl]-5,7-dimethyl-4-oxo-4H-chromene-2-carboxamide chemical structure, C22H23NO5, CAS 898513-73-0

N-[2-(3,4-Dimethoxyphenyl)ethyl]-5,7-dimethyl-4-oxo-4H-chromene-2-carboxamide

CAS 898513-73-0C₂₂H₂₃NO₅

N-[2-(3,4-Dimethoxyphenyl)ethyl]-6,8-dimethyl-4-oxo-4H-chromene-2-carboxamide chemical structure, C22H23NO5, CAS 880789-12-8

N-[2-(3,4-Dimethoxyphenyl)ethyl]-6,8-dimethyl-4-oxo-4H-chromene-2-carboxamide

CAS 880789-12-8C₂₂H₂₃NO₅

N-[2-(4-Aminophenyl)ethyl]-6-chloro-7-methyl-4-oxo-4H-chromene-2-carboxamide chemical structure, C19H17ClN2O3, CAS 874129-02-9

N-[2-(4-Aminophenyl)ethyl]-6-chloro-7-methyl-4-oxo-4H-chromene-2-carboxamide

CAS 874129-02-9C₁₉H₁₇ClN₂O₃

6-Chloro-N-[2-(dimethylamino)-2-phenylethyl]-4-oxo-4H-chromene-2-carboxamide chemical structure, C20H19ClN2O3, CAS 924024-71-5

6-Chloro-N-[2-(dimethylamino)-2-phenylethyl]-4-oxo-4H-chromene-2-carboxamide

CAS 924024-71-5C₂₀H₁₉ClN₂O₃

N-[2-(Dimethylamino)-2-phenylethyl]-4-oxo-4H-chromene-2-carboxamide chemical structure, C20H20N2O3, CAS 1090002-28-0

N-[2-(Dimethylamino)-2-phenylethyl]-4-oxo-4H-chromene-2-carboxamide

CAS 1090002-28-0C₂₀H₂₀N₂O₃

6-Bromo-N-[2-(4-tert-butylphenyl)-2-(dimethylamino)ethyl]-4-oxochromene-2-carboxamide, hydrochloride chemical structure, C24H28BrClN2O3, CAS 1266693-67-7

6-Bromo-N-[2-(4-tert-butylphenyl)-2-(dimethylamino)ethyl]-4-oxochromene-2-carboxamide, hydrochloride

CAS 1266693-67-7C₂₄H₂₈BrClN₂O₃

4-Oxo-N-(3,3,3-trifluoro-2-hydroxy-2-phenylpropyl)-4H-chromene-2-carboxamide chemical structure, C19H14F3NO4, CAS 1351631-78-1

4-Oxo-N-(3,3,3-trifluoro-2-hydroxy-2-phenylpropyl)-4H-chromene-2-carboxamide

CAS 1351631-78-1C₁₉H₁₄F₃NO₄

N-(2-(2-Fluorophenyl)-2-methoxypropyl)-4-oxo-4H-chromene-2-carboxamide chemical structure, C20H18FNO4, CAS 1705986-96-4

N-(2-(2-Fluorophenyl)-2-methoxypropyl)-4-oxo-4H-chromene-2-carboxamide

CAS 1705986-96-4C₂₀H₁₈FNO₄