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Murcko scaffold

2-Phenyl-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone scaffold

23 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 21
Chemicals: 23
With full pages: 5

Scaffold SMILES

O=C(Cc1ccccc1)N1CCN(c2ccccn2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 2-Phenyl-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone page

Murcko scaffold O=C(Cc1ccccc1)N1CCN(c2ccccn2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

2-(4-Methoxyphenyl)-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone chemical structure, C18H21N3O2, CAS 371137-18-7

2-(4-Methoxyphenyl)-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone

CAS 371137-18-7C₁₈H₂₁N₃O₂

2-(4-Nitrophenyl)-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone chemical structure, C17H18N4O3, CAS 426213-99-2

2-(4-Nitrophenyl)-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone

CAS 426213-99-2C₁₇H₁₈N₄O₃

2-(2-Nitrophenyl)-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone chemical structure, C17H18N4O3, CAS 690983-63-2

2-(2-Nitrophenyl)-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone

CAS 690983-63-2C₁₇H₁₈N₄O₃

2-(4-Methylphenyl)-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone chemical structure, C18H21N3O, CAS 694445-50-6

2-(4-Methylphenyl)-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone

CAS 694445-50-6C₁₈H₂₁N₃O

2-(4-Bromophenyl)-1-[4-(2-pyridinyl)-1-piperazinyl]ethanone chemical structure, C17H18BrN3O, CAS 495374-72-6

2-(4-Bromophenyl)-1-[4-(2-pyridinyl)-1-piperazinyl]ethanone

CAS 495374-72-6C₁₇H₁₈BrN₃O

2-Phenyl-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone chemical structure, C17H19N3O, CAS 335282-37-6

2-Phenyl-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone

CAS 335282-37-6C₁₇H₁₉N₃O

2-(3-Methylphenyl)-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone chemical structure, C18H21N3O, CAS 898135-05-2

2-(3-Methylphenyl)-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone

CAS 898135-05-2C₁₈H₂₁N₃O

2-(4-Fluoro-phenyl)-4,4-dimethoxy-1-[4-(4-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-butan-1-one chemical structure, C22H25F4N3O3, CAS 1227268-99-6

2-(4-Fluoro-phenyl)-4,4-dimethoxy-1-[4-(4-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-butan-1-one

CAS 1227268-99-6C₂₂H₂₅F₄N₃O₃

2-[(3S)-4-[2-(2,6-Dichlorophenyl)acetyl]-3-methylpiperazin-1-yl]pyridine-3-carboxylic acid chemical structure, C19H19Cl2N3O3, CAS 2411178-65-7

2-[(3S)-4-[2-(2,6-Dichlorophenyl)acetyl]-3-methylpiperazin-1-yl]pyridine-3-carboxylic acid

CAS 2411178-65-7C₁₉H₁₉Cl₂N₃O₃

1-[4-(6-Fluoropyridin-2-yl)-3-methylpiperazin-1-yl]-2-phenylethan-1-one chemical structure, C18H20FN3O, CAS 3054610-68-0

1-[4-(6-Fluoropyridin-2-yl)-3-methylpiperazin-1-yl]-2-phenylethan-1-one

CAS 3054610-68-0C₁₈H₂₀FN₃O

1-[4-(6-Fluoropyridin-2-yl)-3-methylpiperazin-1-yl]-2-(4-methoxyphenyl)ethan-1-one chemical structure, C19H22FN3O2, CAS 3054617-22-7

1-[4-(6-Fluoropyridin-2-yl)-3-methylpiperazin-1-yl]-2-(4-methoxyphenyl)ethan-1-one

CAS 3054617-22-7C₁₉H₂₂FN₃O₂

1-[4-(6-Fluoropyridin-2-yl)-3-methylpiperazin-1-yl]-2-(4-nitrophenyl)ethan-1-one chemical structure, C18H19FN4O3, CAS 3054616-55-3

1-[4-(6-Fluoropyridin-2-yl)-3-methylpiperazin-1-yl]-2-(4-nitrophenyl)ethan-1-one

CAS 3054616-55-3C₁₈H₁₉FN₄O₃

1-[4-(6-Fluoropyridin-2-yl)-3-methylpiperazin-1-yl]-2-(3-methylphenyl)ethan-1-one chemical structure, C19H22FN3O, CAS 3054598-81-8

1-[4-(6-Fluoropyridin-2-yl)-3-methylpiperazin-1-yl]-2-(3-methylphenyl)ethan-1-one

CAS 3054598-81-8C₁₉H₂₂FN₃O

2-(4-Ethoxyphenyl)-1-[4-(6-fluoropyridin-2-yl)-3-methylpiperazin-1-yl]ethan-1-one chemical structure, C20H24FN3O2, CAS 3054444-68-4

2-(4-Ethoxyphenyl)-1-[4-(6-fluoropyridin-2-yl)-3-methylpiperazin-1-yl]ethan-1-one

CAS 3054444-68-4C₂₀H₂₄FN₃O₂

2-(3,4-Dimethoxyphenyl)-1-[4-(6-fluoropyridin-2-yl)-3-methylpiperazin-1-yl]ethan-1-one chemical structure, C20H24FN3O3, CAS 3054411-41-2

2-(3,4-Dimethoxyphenyl)-1-[4-(6-fluoropyridin-2-yl)-3-methylpiperazin-1-yl]ethan-1-one

CAS 3054411-41-2C₂₀H₂₄FN₃O₃

1-[4-(6-Fluoropyridin-2-yl)-3-methylpiperazin-1-yl]-2-phenylpropan-1-one chemical structure, C19H22FN3O, CAS 3054562-38-5

1-[4-(6-Fluoropyridin-2-yl)-3-methylpiperazin-1-yl]-2-phenylpropan-1-one

CAS 3054562-38-5C₁₉H₂₂FN₃O

1-[4-(6-Fluoropyridin-2-yl)-3-methylpiperazin-1-yl]-2-(3-methoxyphenyl)ethan-1-one chemical structure, C19H22FN3O2, CAS 3054583-83-1

1-[4-(6-Fluoropyridin-2-yl)-3-methylpiperazin-1-yl]-2-(3-methoxyphenyl)ethan-1-one

CAS 3054583-83-1C₁₉H₂₂FN₃O₂

2-(2,3-Difluorophenyl)-1-[4-(6-fluoropyridin-2-yl)-3-methylpiperazin-1-yl]ethan-1-one chemical structure, C18H18F3N3O, CAS 3054603-43-6

2-(2,3-Difluorophenyl)-1-[4-(6-fluoropyridin-2-yl)-3-methylpiperazin-1-yl]ethan-1-one

CAS 3054603-43-6C₁₈H₁₈F₃N₃O

2-(2,6-Difluorophenyl)-1-[4-(6-fluoropyridin-2-yl)-3-methylpiperazin-1-yl]ethan-1-one chemical structure, C18H18F3N3O, CAS 3054583-99-9

2-(2,6-Difluorophenyl)-1-[4-(6-fluoropyridin-2-yl)-3-methylpiperazin-1-yl]ethan-1-one

CAS 3054583-99-9C₁₈H₁₈F₃N₃O

2-(3,5-Dimethoxyphenyl)-1-[4-(6-fluoropyridin-2-yl)-3-methylpiperazin-1-yl]ethan-1-one chemical structure, C20H24FN3O3, CAS 3054412-14-2

2-(3,5-Dimethoxyphenyl)-1-[4-(6-fluoropyridin-2-yl)-3-methylpiperazin-1-yl]ethan-1-one

CAS 3054412-14-2C₂₀H₂₄FN₃O₃

2-(2,5-Dimethoxyphenyl)-1-[4-(6-fluoropyridin-2-yl)-3-methylpiperazin-1-yl]ethan-1-one chemical structure, C20H24FN3O3, CAS 3054630-75-7

2-(2,5-Dimethoxyphenyl)-1-[4-(6-fluoropyridin-2-yl)-3-methylpiperazin-1-yl]ethan-1-one

CAS 3054630-75-7C₂₀H₂₄FN₃O₃

1-[4-(6-Fluoropyridin-2-yl)-3-methylpiperazin-1-yl]-2-[4-(hydroxymethyl)phenyl]ethan-1-one chemical structure, C19H22FN3O2, CAS 3054595-00-2

1-[4-(6-Fluoropyridin-2-yl)-3-methylpiperazin-1-yl]-2-[4-(hydroxymethyl)phenyl]ethan-1-one

CAS 3054595-00-2C₁₉H₂₂FN₃O₂

1-[4-(6-Fluoropyridin-2-yl)-3-methylpiperazin-1-yl]-2-(4-hydroxyphenyl)ethan-1-one chemical structure, C18H20FN3O2, CAS 3054539-92-0

1-[4-(6-Fluoropyridin-2-yl)-3-methylpiperazin-1-yl]-2-(4-hydroxyphenyl)ethan-1-one

CAS 3054539-92-0C₁₈H₂₀FN₃O₂