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Murcko scaffold

Ring system with 4 rings and 24 atoms

52 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
52
With full pages
4
Scaffold SMILES

O=C(NCc1ccsc1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCc1ccsc1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 52 chemicals

(3R)-3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(thiophen-3-yl)propanoic acid chemical structure, C22H19NO4S, CAS 511272-46-1
(3R)-3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(thiophen-3-yl)propanoic acid
CAS 511272-46-1C22H19NO4S
(3S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-3-yl)propanoic acid chemical structure, C22H19NO4S, CAS 507472-09-5
(3S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-3-yl)propanoic acid
CAS 507472-09-5C22H19NO4S
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(thiophen-3-yl)acetic acid chemical structure, C21H17NO4S, CAS 1217706-09-6
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(thiophen-3-yl)acetic acid
CAS 1217706-09-6C21H17NO4S
2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(thiophen-3-yl)acetic acid chemical structure, C21H17NO4S, CAS 372143-96-9
2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(thiophen-3-yl)acetic acid
CAS 372143-96-9C21H17NO4S
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(thiophen-3-yl)propanoic acid chemical structure, C22H19NO4S, CAS 282525-11-5
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(thiophen-3-yl)propanoic acid
CAS 282525-11-5C22H19NO4S
Fmoc-(R)-3-Thienylglycine chemical structure, C21H17NO4S, CAS 1217774-71-4
Fmoc-(R)-3-Thienylglycine
CAS 1217774-71-4C21H17NO4S
(3R)-3-(2,5-Dimethylthiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C24H23NO4S, CAS 1366349-65-6
(3R)-3-(2,5-Dimethylthiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1366349-65-6C24H23NO4S
(3S)-3-(2,5-Dimethylthiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C24H23NO4S, CAS 1366368-66-2
(3S)-3-(2,5-Dimethylthiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1366368-66-2C24H23NO4S
3-(2,5-Dimethylthiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C24H23NO4S, CAS 1699010-75-7
3-(2,5-Dimethylthiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1699010-75-7C24H23NO4S
(9H-Fluoren-9-yl)methyl [3-hydroxy-1-(thiophen-3-yl)propyl]carbamate chemical structure, C22H21NO3S, CAS 683220-38-4
(9H-Fluoren-9-yl)methyl [3-hydroxy-1-(thiophen-3-yl)propyl]carbamate
CAS 683220-38-4C22H21NO3S
3-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]thiophene-2-carboxylic acid chemical structure, C21H17NO4S, CAS 2172256-21-0
3-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]thiophene-2-carboxylic acid
CAS 2172256-21-0C21H17NO4S
5-Chloro-4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]thiophene-2-carboxylic acid chemical structure, C21H16ClNO4S, CAS 2174002-02-7
5-Chloro-4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]thiophene-2-carboxylic acid
CAS 2174002-02-7C21H16ClNO4S
4-[(9H-Fluoren-9-ylmethoxycarbonylamino)methyl]thiophene-2-carboxylic acid chemical structure, C21H17NO4S, CAS 503469-94-1
4-[(9H-Fluoren-9-ylmethoxycarbonylamino)methyl]thiophene-2-carboxylic acid
CAS 503469-94-1C21H17NO4S
(3R)-3-(2-Chlorothiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18ClNO4S, CAS 1366487-68-4
(3R)-3-(2-Chlorothiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1366487-68-4C22H18ClNO4S
(3R)-3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(5-methylthiophen-3-yl)propanoic acid chemical structure, C23H21NO4S, CAS 1366370-41-3
(3R)-3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(5-methylthiophen-3-yl)propanoic acid
CAS 1366370-41-3C23H21NO4S
(3S)-3-(5-Bromothiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18BrNO4S, CAS 1366313-51-0
(3S)-3-(5-Bromothiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1366313-51-0C22H18BrNO4S
(3S)-3-(4-Bromothiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18BrNO4S, CAS 1366325-54-3
(3S)-3-(4-Bromothiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1366325-54-3C22H18BrNO4S
(3S)-3-(2,5-Dichlorothiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H17Cl2NO4S, CAS 1993326-66-1
(3S)-3-(2,5-Dichlorothiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1993326-66-1C22H17Cl2NO4S
(3R)-3-(2-Bromothiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18BrNO4S, CAS 1366392-04-2
(3R)-3-(2-Bromothiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1366392-04-2C22H18BrNO4S
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(2-methylthiophen-3-yl)propanoic acid chemical structure, C23H21NO4S, CAS 1881648-01-6
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(2-methylthiophen-3-yl)propanoic acid
CAS 1881648-01-6C23H21NO4S
3-(4-Bromothiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18BrNO4S, CAS 1869745-68-5
3-(4-Bromothiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1869745-68-5C22H18BrNO4S
3-(2-Chlorothiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18ClNO4S, CAS 1999494-06-2
3-(2-Chlorothiophen-3-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1999494-06-2C22H18ClNO4S
4-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}(methyl)amino)methyl]-5-[(methylamino)methyl]thiophene-2-carboxylic acid chemical structure, C24H24N2O4S, CAS 2171881-16-4
4-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}(methyl)amino)methyl]-5-[(methylamino)methyl]thiophene-2-carboxylic acid
CAS 2171881-16-4C24H24N2O4S
4-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]-5-methylthiophene-2-carboxylic acid chemical structure, C22H19NO4S, CAS 2171877-51-1
4-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]-5-methylthiophene-2-carboxylic acid
CAS 2171877-51-1C22H19NO4S