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Murcko scaffold

Ring system with 4 rings and 24 atoms

187 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
187
With full pages
4
Scaffold SMILES

O=C(NCc1cccs1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCc1cccs1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 187 chemicals

(R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-2-yl)propanoic acid chemical structure, C22H19NO4S, CAS 511272-45-0
(R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-2-yl)propanoic acid
CAS 511272-45-0C22H19NO4S
(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-2-yl)propanoic acid chemical structure, C22H19NO4S, CAS 507472-08-4
(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-2-yl)propanoic acid
CAS 507472-08-4C22H19NO4S
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(thiophen-2-yl)acetic acid chemical structure, C21H17NO4S, CAS 208259-66-9
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(thiophen-2-yl)acetic acid
CAS 208259-66-9C21H17NO4S
5-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)thiophene-2-carboxylic acid chemical structure, C21H17NO4S, CAS 476362-75-1
5-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)thiophene-2-carboxylic acid
CAS 476362-75-1C21H17NO4S
5-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]thiophene-3-carboxylic acid chemical structure, C21H17NO4S, CAS 476362-79-5
5-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]thiophene-3-carboxylic acid
CAS 476362-79-5C21H17NO4S
3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-2-yl)propanoic acid chemical structure, C22H19NO4S, CAS 282525-12-6
3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-2-yl)propanoic acid
CAS 282525-12-6C22H19NO4S
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(thiophen-2-yl)acetic acid chemical structure, C21H17NO4S, CAS 211682-13-2
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(thiophen-2-yl)acetic acid
CAS 211682-13-2C21H17NO4S
2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(thiophen-2-yl)acetic acid chemical structure, C21H17NO4S, CAS 211682-11-0
2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(thiophen-2-yl)acetic acid
CAS 211682-11-0C21H17NO4S
2-(4-Bromo-5-methylthiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetic acid chemical structure, C22H18BrNO4S, CAS 1702998-81-9
2-(4-Bromo-5-methylthiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetic acid
CAS 1702998-81-9C22H18BrNO4S
3-(4-Bromo-5-methylthiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C23H20BrNO4S, CAS 1697073-60-1
3-(4-Bromo-5-methylthiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1697073-60-1C23H20BrNO4S
(3S)-3-(4-Bromo-5-chlorothiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H17BrClNO4S, CAS 1704945-34-5
(3S)-3-(4-Bromo-5-chlorothiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1704945-34-5C22H17BrClNO4S
(3S)-3-(4-Bromo-5-methylthiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C23H20BrNO4S, CAS 1704951-82-5
(3S)-3-(4-Bromo-5-methylthiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1704951-82-5C23H20BrNO4S
(3R)-3-(4-Bromo-5-chlorothiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H17BrClNO4S, CAS 1704939-54-7
(3R)-3-(4-Bromo-5-chlorothiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1704939-54-7C22H17BrClNO4S
(3R)-3-(4-Bromo-5-methylthiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C23H20BrNO4S, CAS 1704977-42-3
(3R)-3-(4-Bromo-5-methylthiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1704977-42-3C23H20BrNO4S
2-(5-Bromothiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetic acid chemical structure, C21H16BrNO4S, CAS 1693685-39-0
2-(5-Bromothiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetic acid
CAS 1693685-39-0C21H16BrNO4S
2-(4-Bromothiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetic acid chemical structure, C21H16BrNO4S, CAS 1690939-75-3
2-(4-Bromothiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetic acid
CAS 1690939-75-3C21H16BrNO4S
2-(5-Bromothiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)acetic acid chemical structure, C22H18BrNO4S, CAS 1690770-05-8
2-(5-Bromothiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)acetic acid
CAS 1690770-05-8C22H18BrNO4S
2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-2-(thiophen-2-yl)acetic acid chemical structure, C22H19NO4S, CAS 1692806-77-1
2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-2-(thiophen-2-yl)acetic acid
CAS 1692806-77-1C22H19NO4S
(3R)-3-(4-Bromothiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18BrNO4S, CAS 1366359-39-8
(3R)-3-(4-Bromothiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1366359-39-8C22H18BrNO4S
3-(5-Bromothiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18BrNO4S, CAS 282525-19-3
3-(5-Bromothiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 282525-19-3C22H18BrNO4S
(3S)-3-(5-Ethylthiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C24H23NO4S, CAS 1366496-07-2
(3S)-3-(5-Ethylthiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1366496-07-2C24H23NO4S
(3S)-3-(5-Chlorothiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18ClNO4S, CAS 1366349-01-0
(3S)-3-(5-Chlorothiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1366349-01-0C22H18ClNO4S
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(3-methylthiophen-2-yl)propanoic acid chemical structure, C23H21NO4S, CAS 683217-40-5
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(3-methylthiophen-2-yl)propanoic acid
CAS 683217-40-5C23H21NO4S
3-(5-Chlorothiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18ClNO4S, CAS 282525-18-2
3-(5-Chlorothiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 282525-18-2C22H18ClNO4S