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Murcko scaffold

Ring system with 3 rings and 22 atoms

376 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
376
With full pages
5
Scaffold SMILES

O=C(Nc1ccccc1)C1=CNC(=S)NC1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)C1=CNC(=S)NC1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 337 to 376 of 376 chemicals

4-(3-Chlorophenyl)-N-(2-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C18H15ClFN3OS, CAS 893680-29-0
4-(3-Chlorophenyl)-N-(2-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 893680-29-0C18H15ClFN3OS
N,4-bis(2-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C18H15F2N3OS, CAS 893680-35-8
N,4-bis(2-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 893680-35-8C18H15F2N3OS
4-(2,4-Dimethoxyphenyl)-N-(2-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20FN3O3S, CAS 893680-47-2
4-(2,4-Dimethoxyphenyl)-N-(2-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 893680-47-2C20H20FN3O3S
4-(4-Bromophenyl)-N-(2-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C18H15BrFN3OS, CAS 893680-53-0
4-(4-Bromophenyl)-N-(2-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 893680-53-0C18H15BrFN3OS
4-(2,4-Dichlorophenyl)-N-(2-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C18H14Cl2FN3OS, CAS 893680-70-1
4-(2,4-Dichlorophenyl)-N-(2-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 893680-70-1C18H14Cl2FN3OS
4-(4-Chloro-3-nitrophenyl)-N-(2-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C18H14ClFN4O3S, CAS 893680-84-7
4-(4-Chloro-3-nitrophenyl)-N-(2-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 893680-84-7C18H14ClFN4O3S
4-(3,4-Dimethoxyphenyl)-N-(3,4-dimethylphenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C22H25N3O3S, CAS 406690-58-2
4-(3,4-Dimethoxyphenyl)-N-(3,4-dimethylphenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 406690-58-2C22H25N3O3S
N-(3,4-Dimethylphenyl)-6-methyl-2-thioxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C23H27N3O4S, CAS 406691-60-9
N-(3,4-Dimethylphenyl)-6-methyl-2-thioxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 406691-60-9C23H27N3O4S
N-(3,5-Dimethylphenyl)-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C21H23N3O2S, CAS 459201-67-3
N-(3,5-Dimethylphenyl)-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 459201-67-3C21H23N3O2S
N-(2,5-Dimethylphenyl)-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C21H23N3O2S, CAS 941897-99-0
N-(2,5-Dimethylphenyl)-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 941897-99-0C21H23N3O2S
N-(3,4-Dimethylphenyl)-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C21H23N3O2S, CAS 941948-10-3
N-(3,4-Dimethylphenyl)-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 941948-10-3C21H23N3O2S
N-(4-Bromophenyl)-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C19H18BrN3O2S, CAS 455927-78-3
N-(4-Bromophenyl)-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 455927-78-3C19H18BrN3O2S
N-(3,5-Dimethylphenyl)-4-(3-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C21H23N3O2S, CAS 941948-13-6
N-(3,5-Dimethylphenyl)-4-(3-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 941948-13-6C21H23N3O2S
N-(2,5-Dimethylphenyl)-4-(3-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C21H23N3O2S, CAS 941944-35-0
N-(2,5-Dimethylphenyl)-4-(3-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 941944-35-0C21H23N3O2S
N-(4-Bromophenyl)-4-(2-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C19H18BrN3O2S, CAS 941944-38-3
N-(4-Bromophenyl)-4-(2-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 941944-38-3C19H18BrN3O2S
N-(4-Bromophenyl)-4-(3,4-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20BrN3O3S, CAS 941948-16-9
N-(4-Bromophenyl)-4-(3,4-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 941948-16-9C20H20BrN3O3S
N-(4-Bromophenyl)-4-(4-ethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20BrN3O2S, CAS 899081-23-3
N-(4-Bromophenyl)-4-(4-ethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 899081-23-3C20H20BrN3O2S
N-(3,4-Dimethylphenyl)-4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C22H25N3O3S, CAS 941898-08-4
N-(3,4-Dimethylphenyl)-4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 941898-08-4C22H25N3O3S
4-(2-Chlorophenyl)-N-(3,4-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20ClN3OS, CAS 406690-72-0
4-(2-Chlorophenyl)-N-(3,4-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 406690-72-0C20H20ClN3OS
4-(3-Chlorophenyl)-N-(3,4-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20ClN3OS, CAS 406690-32-2
4-(3-Chlorophenyl)-N-(3,4-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 406690-32-2C20H20ClN3OS
4-(4-Chloro-3-nitrophenyl)-N-(3,4-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H19ClN4O3S, CAS 941898-11-9
4-(4-Chloro-3-nitrophenyl)-N-(3,4-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 941898-11-9C20H19ClN4O3S
4-(4-Chloro-3-nitrophenyl)-N-(3-chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C18H14Cl2N4O3S, CAS 901450-45-1
4-(4-Chloro-3-nitrophenyl)-N-(3-chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 901450-45-1C18H14Cl2N4O3S
N-(4-Bromophenyl)-4-(4-(dimethylamino)phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H21BrN4OS, CAS 941944-44-1
N-(4-Bromophenyl)-4-(4-(dimethylamino)phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 941944-44-1C20H21BrN4OS
N-(3-Chlorophenyl)-4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20ClN3O3S, CAS 941948-22-7
N-(3-Chlorophenyl)-4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 941948-22-7C20H20ClN3O3S