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Murcko scaffold

Ring system with 4 rings and 24 atoms

5 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
5
With full pages
2
Scaffold SMILES

O=C(c1ccccc1)N1N=C(c2cccs2)CC1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)N1N=C(c2cccs2)CC1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 5 of 5 chemicals

[3-(3,4-Dimethoxyphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-phenylmethanone chemical structure, C22H20N2O3S, CAS 701247-23-6
[3-(3,4-Dimethoxyphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-phenylmethanone
CAS 701247-23-6C22H20N2O3S
Ethyl 2-[2-(2-benzoyl-5-thiophen-2-yl-3,4-dihydropyrazol-3-yl)phenoxy]acetate chemical structure, C24H22N2O4S, CAS 831232-46-3
Ethyl 2-[2-(2-benzoyl-5-thiophen-2-yl-3,4-dihydropyrazol-3-yl)phenoxy]acetate
CAS 831232-46-3C24H22N2O4S
(4-Chlorophenyl)-(3-phenyl-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl)methanone chemical structure, C20H15ClN2OS, CAS 445458-65-1
(4-Chlorophenyl)-(3-phenyl-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl)methanone
CAS 445458-65-1C20H15ClN2OS
(5-(2-Hydroxy-3-methoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)(4-methoxyphenyl)methanone chemical structure, C22H20N2O4S, CAS 871225-63-7
(5-(2-Hydroxy-3-methoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)(4-methoxyphenyl)methanone
CAS 871225-63-7C22H20N2O4S
2-[1-(4-Methoxybenzoyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-5-yl]phenol chemical structure, C21H18N2O3S, CAS 871307-82-3
2-[1-(4-Methoxybenzoyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-5-yl]phenol
CAS 871307-82-3C21H18N2O3S