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Murcko scaffold

Ring system with 3 rings and 19 atoms

36 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
36
With full pages
8
Scaffold SMILES

c1ccc(Nc2ccnc(-c3ccccc3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Nc2ccnc(-c3ccccc3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 36 of 36 chemicals

4-Pyrimidinamine, 6-methyl-N-(4-nitrophenyl)-2-phenyl-5-(2-propenyl)- chemical structure, C20H18N4O2, CAS 330819-79-9
4-Pyrimidinamine, 6-methyl-N-(4-nitrophenyl)-2-phenyl-5-(2-propenyl)-
CAS 330819-79-9C20H18N4O2
1-[4-[(6-Methyl-2-phenyl-5-prop-2-enylpyrimidin-4-yl)amino]phenyl]ethanone chemical structure, C22H21N3O, CAS 330998-12-4
1-[4-[(6-Methyl-2-phenyl-5-prop-2-enylpyrimidin-4-yl)amino]phenyl]ethanone
CAS 330998-12-4C22H21N3O
5-Allyl-N-(4-methoxyphenyl)-6-methyl-2-phenyl-4-pyrimidinamine chemical structure, C21H21N3O, CAS 330998-11-3
5-Allyl-N-(4-methoxyphenyl)-6-methyl-2-phenyl-4-pyrimidinamine
CAS 330998-11-3C21H21N3O
RefChem:382049 chemical structure, C20H19N3O2, CAS 65789-90-4
RefChem:382049
CAS 65789-90-4C20H19N3O2
N-(4-Methoxyphenyl)-6-methyl-2-phenylpyrimidin-4-amine chemical structure, C18H17N3O, CAS 300359-08-4
N-(4-Methoxyphenyl)-6-methyl-2-phenylpyrimidin-4-amine
CAS 300359-08-4C18H17N3O
2-[4-(2-Fluoro-phenylamino)-6-methyl-pyrimidin-2-yl]-phenol chemical structure, C17H14FN3O, CAS 4635-72-7
2-[4-(2-Fluoro-phenylamino)-6-methyl-pyrimidin-2-yl]-phenol
CAS 4635-72-7C17H14FN3O
2-{4-[(2,5-Dimethylphenyl)amino]-6-methylpyrimidin-2-yl}phenol chemical structure, C19H19N3O, CAS 380473-18-7
2-{4-[(2,5-Dimethylphenyl)amino]-6-methylpyrimidin-2-yl}phenol
CAS 380473-18-7C19H19N3O
2-(4-((4-Methoxyphenyl)amino)-6-methylpyrimidin-2-yl)phenol chemical structure, C18H17N3O2, CAS 331648-44-3
2-(4-((4-Methoxyphenyl)amino)-6-methylpyrimidin-2-yl)phenol
CAS 331648-44-3C18H17N3O2
4-((5-Allyl-6-methyl-2-phenylpyrimidin-4-yl)amino)benzoic acid chemical structure, C21H19N3O2, CAS 300837-31-4
4-((5-Allyl-6-methyl-2-phenylpyrimidin-4-yl)amino)benzoic acid
CAS 300837-31-4C21H19N3O2
Ethyl 4-((2-(2-hydroxyphenyl)-6-methylpyrimidin-4-yl)amino)benzoate chemical structure, C20H19N3O3, CAS 371199-20-1
Ethyl 4-((2-(2-hydroxyphenyl)-6-methylpyrimidin-4-yl)amino)benzoate
CAS 371199-20-1C20H19N3O3
4-[(6-Methyl-2-phenylpyrimidin-4-yl)amino]benzoic acid chemical structure, C18H15N3O2, CAS 312626-15-6
4-[(6-Methyl-2-phenylpyrimidin-4-yl)amino]benzoic acid
CAS 312626-15-6C18H15N3O2
2-(4-((4-Bromophenyl)amino)-6-methylpyrimidin-2-yl)phenol chemical structure, C17H14BrN3O, CAS 331648-43-2
2-(4-((4-Bromophenyl)amino)-6-methylpyrimidin-2-yl)phenol
CAS 331648-43-2C17H14BrN3O
6-Methyl-N-(4-methylphenyl)-2-phenyl-5-prop-2-enylpyrimidin-4-amine chemical structure, C21H21N3, CAS 301352-40-9
6-Methyl-N-(4-methylphenyl)-2-phenyl-5-prop-2-enylpyrimidin-4-amine
CAS 301352-40-9C21H21N3
2-(4-Methyl-6-((4-nitrophenyl)amino)pyrimidin-2-yl)phenol chemical structure, C17H14N4O3, CAS 371199-57-4
2-(4-Methyl-6-((4-nitrophenyl)amino)pyrimidin-2-yl)phenol
CAS 371199-57-4C17H14N4O3
Benzoic acid, 4-((2-(3-fluorophenyl)-6-methyl-4-pyrimidinyl)amino)-, ethyl ester chemical structure, C20H18FN3O2, CAS 56302-63-7
Benzoic acid, 4-((2-(3-fluorophenyl)-6-methyl-4-pyrimidinyl)amino)-, ethyl ester
CAS 56302-63-7C20H18FN3O2
Benzamide, 4-((6-methyl-2-(3,4,5-trimethoxyphenyl)-4-pyrimidinyl)amino)- chemical structure, C21H22N4O4, CAS 56302-88-6
Benzamide, 4-((6-methyl-2-(3,4,5-trimethoxyphenyl)-4-pyrimidinyl)amino)-
CAS 56302-88-6C21H22N4O4
4-Pyrimidineacetamide, 6-((2-(aminocarbonyl)phenyl)amino)-2-(4-chlorophenyl)-N-hydroxy- chemical structure, C19H16ClN5O3, CAS 57630-88-3
4-Pyrimidineacetamide, 6-((2-(aminocarbonyl)phenyl)amino)-2-(4-chlorophenyl)-N-hydroxy-
CAS 57630-88-3C19H16ClN5O3
4-Pyrimidineacetamide, 6-((2-(aminocarbonyl)phenyl)amino)-2-(3-fluorophenyl)-N-hydroxy- chemical structure, C19H16FN5O3, CAS 57630-93-0
4-Pyrimidineacetamide, 6-((2-(aminocarbonyl)phenyl)amino)-2-(3-fluorophenyl)-N-hydroxy-
CAS 57630-93-0C19H16FN5O3
4-Pyrimidineacetamide, 6-((2-(aminocarbonyl)phenyl)amino)-N-hydroxy-2-(3-(trifluoromethyl)phenyl)- chemical structure, C20H16F3N5O3, CAS 57630-94-1
4-Pyrimidineacetamide, 6-((2-(aminocarbonyl)phenyl)amino)-N-hydroxy-2-(3-(trifluoromethyl)phenyl)-
CAS 57630-94-1C20H16F3N5O3
4-Pyrimidineacetamide, 6-((4-(aminocarbonyl)phenyl)amino)-N-hydroxy-2-(3-(trifluoromethyl)phenyl)- chemical structure, C20H16F3N5O3, CAS 57630-95-2
4-Pyrimidineacetamide, 6-((4-(aminocarbonyl)phenyl)amino)-N-hydroxy-2-(3-(trifluoromethyl)phenyl)-
CAS 57630-95-2C20H16F3N5O3
4-Pyrimidineacetamide, 6-((2-(aminocarbonyl)phenyl)amino)-N-hydroxy-2-(3,4,5-trimethoxyphenyl)- chemical structure, C22H23N5O6, CAS 57630-98-5
4-Pyrimidineacetamide, 6-((2-(aminocarbonyl)phenyl)amino)-N-hydroxy-2-(3,4,5-trimethoxyphenyl)-
CAS 57630-98-5C22H23N5O6
4-Pyrimidineacetamide, 6-((4-(aminocarbonyl)phenyl)amino)-N-hydroxy-2-(3,4,5-trimethoxyphenyl)- chemical structure, C22H23N5O6, CAS 57630-99-6
4-Pyrimidineacetamide, 6-((4-(aminocarbonyl)phenyl)amino)-N-hydroxy-2-(3,4,5-trimethoxyphenyl)-
CAS 57630-99-6C22H23N5O6
4-Pyrimidineacetamide, 6-((2-(aminocarbonyl)phenyl)amino)-2-(3-chlorophenyl)-N-hydroxy- chemical structure, C19H16ClN5O3, CAS 57659-74-2
4-Pyrimidineacetamide, 6-((2-(aminocarbonyl)phenyl)amino)-2-(3-chlorophenyl)-N-hydroxy-
CAS 57659-74-2C19H16ClN5O3
N-Methyl-6-((methylsulfanyl)methyl)-N,2-diphenyl-4-pyrimidinamine chemical structure, C19H19N3S, CAS 478031-64-0
N-Methyl-6-((methylsulfanyl)methyl)-N,2-diphenyl-4-pyrimidinamine
CAS 478031-64-0C19H19N3S