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Murcko scaffold

Ring system with 3 rings and 19 atoms

51 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
51
With full pages
17
Scaffold SMILES

c1ccc(Sc2ccnc(-c3ccccc3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Sc2ccnc(-c3ccccc3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 51 chemicals

4-((Methylsulfanyl)methyl)-2-phenyl-6-(phenylsulfanyl)pyrimidine chemical structure, C18H16N2S2, CAS 477886-15-0
4-((Methylsulfanyl)methyl)-2-phenyl-6-(phenylsulfanyl)pyrimidine
CAS 477886-15-0C18H16N2S2
Methyl 4-(phenylsulfanyl)-2-[3-(trifluoromethyl)phenyl]-5-pyrimidinyl ether chemical structure, C18H13F3N2OS, CAS 478030-30-7
Methyl 4-(phenylsulfanyl)-2-[3-(trifluoromethyl)phenyl]-5-pyrimidinyl ether
CAS 478030-30-7C18H13F3N2OS
Ethyl 4-[(4-chlorophenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylate chemical structure, C19H15ClN2O2S, CAS 477854-48-1
Ethyl 4-[(4-chlorophenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylate
CAS 477854-48-1C19H15ClN2O2S
4-[(4-Chlorophenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylic acid chemical structure, C17H11ClN2O2S, CAS 477854-49-2
4-[(4-Chlorophenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylic acid
CAS 477854-49-2C17H11ClN2O2S
Ethyl 2-phenyl-4-(phenylsulfanyl)-5-pyrimidinecarboxylate chemical structure, C19H16N2O2S, CAS 477854-50-5
Ethyl 2-phenyl-4-(phenylsulfanyl)-5-pyrimidinecarboxylate
CAS 477854-50-5C19H16N2O2S
2-Phenyl-4-(phenylsulfanyl)-5-pyrimidinecarboxylic acid chemical structure, C17H12N2O2S, CAS 477854-51-6
2-Phenyl-4-(phenylsulfanyl)-5-pyrimidinecarboxylic acid
CAS 477854-51-6C17H12N2O2S
Ethyl 4-[(4-methylphenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylate chemical structure, C20H18N2O2S, CAS 477854-52-7
Ethyl 4-[(4-methylphenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylate
CAS 477854-52-7C20H18N2O2S
4-[(4-Methylphenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylic acid chemical structure, C18H14N2O2S, CAS 477854-53-8
4-[(4-Methylphenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylic acid
CAS 477854-53-8C18H14N2O2S
Ethyl 4-[(3-chlorophenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylate chemical structure, C19H15ClN2O2S, CAS 477854-54-9
Ethyl 4-[(3-chlorophenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylate
CAS 477854-54-9C19H15ClN2O2S
4-[(3-Chlorophenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylic acid chemical structure, C17H11ClN2O2S, CAS 477854-55-0
4-[(3-Chlorophenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylic acid
CAS 477854-55-0C17H11ClN2O2S
2-Phenyl-4-{[3-(trifluoromethyl)phenyl]sulfanyl}-5-pyrimidinecarboxylic acid chemical structure, C18H11F3N2O2S, CAS 477854-57-2
2-Phenyl-4-{[3-(trifluoromethyl)phenyl]sulfanyl}-5-pyrimidinecarboxylic acid
CAS 477854-57-2C18H11F3N2O2S
Ethyl 4-[(3-methylphenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylate chemical structure, C20H18N2O2S, CAS 477854-58-3
Ethyl 4-[(3-methylphenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylate
CAS 477854-58-3C20H18N2O2S
4-[(3-Methylphenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylic acid chemical structure, C18H14N2O2S, CAS 477854-59-4
4-[(3-Methylphenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylic acid
CAS 477854-59-4C18H14N2O2S
Ethyl 4-[(4-methoxyphenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylate chemical structure, C20H18N2O3S, CAS 477854-62-9
Ethyl 4-[(4-methoxyphenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylate
CAS 477854-62-9C20H18N2O3S
4-[(4-Methoxyphenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylic acid chemical structure, C18H14N2O3S, CAS 477854-63-0
4-[(4-Methoxyphenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylic acid
CAS 477854-63-0C18H14N2O3S
Ethyl 4-[(2,5-dimethylphenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylate chemical structure, C21H20N2O2S, CAS 477854-64-1
Ethyl 4-[(2,5-dimethylphenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylate
CAS 477854-64-1C21H20N2O2S
Ethyl 4-[(2-chlorophenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylate chemical structure, C19H15ClN2O2S, CAS 400076-28-0
Ethyl 4-[(2-chlorophenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylate
CAS 400076-28-0C19H15ClN2O2S
4-[(2-Chlorophenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylic acid chemical structure, C17H11ClN2O2S, CAS 400076-29-1
4-[(2-Chlorophenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylic acid
CAS 400076-29-1C17H11ClN2O2S
4-[(2,4-Dichlorophenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylic acid chemical structure, C17H10Cl2N2O2S, CAS 477854-70-9
4-[(2,4-Dichlorophenyl)sulfanyl]-2-phenyl-5-pyrimidinecarboxylic acid
CAS 477854-70-9C17H10Cl2N2O2S
4-[(2,3-Dichlorophenyl)sulfanyl]-6-(methoxymethyl)-2-phenylpyrimidine chemical structure, C18H14Cl2N2OS, CAS 339279-05-9
4-[(2,3-Dichlorophenyl)sulfanyl]-6-(methoxymethyl)-2-phenylpyrimidine
CAS 339279-05-9C18H14Cl2N2OS
4-[(2,6-Dichlorophenyl)sulfanyl]-6-(methoxymethyl)-2-phenylpyrimidine chemical structure, C18H14Cl2N2OS, CAS 339279-06-0
4-[(2,6-Dichlorophenyl)sulfanyl]-6-(methoxymethyl)-2-phenylpyrimidine
CAS 339279-06-0C18H14Cl2N2OS
4-[(2,4-Dichlorophenyl)sulfanyl]-6-(methoxymethyl)-2-phenylpyrimidine chemical structure, C18H14Cl2N2OS, CAS 339279-07-1
4-[(2,4-Dichlorophenyl)sulfanyl]-6-(methoxymethyl)-2-phenylpyrimidine
CAS 339279-07-1C18H14Cl2N2OS
4-[(4-Bromophenyl)sulfanyl]-6-(methoxymethyl)-2-phenylpyrimidine chemical structure, C18H15BrN2OS, CAS 339279-08-2
4-[(4-Bromophenyl)sulfanyl]-6-(methoxymethyl)-2-phenylpyrimidine
CAS 339279-08-2C18H15BrN2OS
4-(Methoxymethyl)-6-[(4-methoxyphenyl)sulfanyl]-2-phenylpyrimidine chemical structure, C19H18N2O2S, CAS 339279-21-9
4-(Methoxymethyl)-6-[(4-methoxyphenyl)sulfanyl]-2-phenylpyrimidine
CAS 339279-21-9C19H18N2O2S