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Murcko scaffold

Ring system with 3 rings and 19 atoms

25 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
25
With full pages
10
Scaffold SMILES

c1ccc(Sc2ccnc(-c3ccccn3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Sc2ccnc(-c3ccccn3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

5-Methoxy-4-(2-methoxyphenyl)sulfanyl-2-pyridin-2-ylpyrimidine chemical structure, C17H15N3O2S, CAS 338771-65-6
5-Methoxy-4-(2-methoxyphenyl)sulfanyl-2-pyridin-2-ylpyrimidine
CAS 338771-65-6C17H15N3O2S
4-((2,4-Dichlorophenyl)sulfanyl)-5-methoxy-2-(2-pyridinyl)pyrimidine chemical structure, C16H11Cl2N3OS, CAS 338771-67-8
4-((2,4-Dichlorophenyl)sulfanyl)-5-methoxy-2-(2-pyridinyl)pyrimidine
CAS 338771-67-8C16H11Cl2N3OS
4-[(2,6-Dichlorophenyl)thio]-5-methoxy-2-(2-pyridinyl)pyrimidine chemical structure, C16H11Cl2N3OS, CAS 338772-29-5
4-[(2,6-Dichlorophenyl)thio]-5-methoxy-2-(2-pyridinyl)pyrimidine
CAS 338772-29-5C16H11Cl2N3OS
Methyl 4-[(4-methylphenyl)sulfanyl]-2-(2-pyridinyl)-5-pyrimidinyl ether chemical structure, C17H15N3OS, CAS 338772-31-9
Methyl 4-[(4-methylphenyl)sulfanyl]-2-(2-pyridinyl)-5-pyrimidinyl ether
CAS 338772-31-9C17H15N3OS
4-((Methylsulfanyl)methyl)-6-(phenylsulfanyl)-2-(2-pyridinyl)pyrimidine chemical structure, C17H15N3S2, CAS 477886-23-0
4-((Methylsulfanyl)methyl)-6-(phenylsulfanyl)-2-(2-pyridinyl)pyrimidine
CAS 477886-23-0C17H15N3S2
4-(Phenylsulfanyl)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine chemical structure, C16H10F3N3S, CAS 338404-82-3
4-(Phenylsulfanyl)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine
CAS 338404-82-3C16H10F3N3S
Methyl 4-{[2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl]sulfanyl}phenyl ether chemical structure, C17H12F3N3OS, CAS 338418-07-8
Methyl 4-{[2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl]sulfanyl}phenyl ether
CAS 338418-07-8C17H12F3N3OS
4-Chlorophenyl 2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl sulfide chemical structure, C16H9ClF3N3S, CAS 338418-08-9
4-Chlorophenyl 2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl sulfide
CAS 338418-08-9C16H9ClF3N3S
4-[(4-Chlorophenyl)sulfanyl]-2-(2-pyridinyl)-5-pyrimidinyl methyl ether chemical structure, C16H12ClN3OS, CAS 321432-96-6
4-[(4-Chlorophenyl)sulfanyl]-2-(2-pyridinyl)-5-pyrimidinyl methyl ether
CAS 321432-96-6C16H12ClN3OS
Methyl 2-(2-pyridinyl)-4-{[3-(trifluoromethyl)phenyl]sulfanyl}-5-pyrimidinyl ether chemical structure, C17H12F3N3OS, CAS 321432-99-9
Methyl 2-(2-pyridinyl)-4-{[3-(trifluoromethyl)phenyl]sulfanyl}-5-pyrimidinyl ether
CAS 321432-99-9C17H12F3N3OS
5-Methoxy-4-[(4-methoxyphenyl)sulfanyl]-2-(2-pyridinyl)pyrimidine chemical structure, C17H15N3O2S, CAS 321433-00-5
5-Methoxy-4-[(4-methoxyphenyl)sulfanyl]-2-(2-pyridinyl)pyrimidine
CAS 321433-00-5C17H15N3O2S
4-[(4-Fluorophenyl)sulfanyl]-2-(2-pyridinyl)-5-pyrimidinyl methyl ether chemical structure, C16H12FN3OS, CAS 321433-01-6
4-[(4-Fluorophenyl)sulfanyl]-2-(2-pyridinyl)-5-pyrimidinyl methyl ether
CAS 321433-01-6C16H12FN3OS
Methyl 4-(phenylsulfanyl)-2-(2-pyridinyl)-5-pyrimidinyl ether chemical structure, C16H13N3OS, CAS 321433-02-7
Methyl 4-(phenylsulfanyl)-2-(2-pyridinyl)-5-pyrimidinyl ether
CAS 321433-02-7C16H13N3OS
4-[(3-Chlorophenyl)sulfanyl]-2-(2-pyridinyl)-5-pyrimidinyl methyl ether chemical structure, C16H12ClN3OS, CAS 338771-11-2
4-[(3-Chlorophenyl)sulfanyl]-2-(2-pyridinyl)-5-pyrimidinyl methyl ether
CAS 338771-11-2C16H12ClN3OS
2-(2-Pyridinyl)-4-(trifluoromethyl)-6-{[3-(trifluoromethyl)phenyl]sulfanyl}pyrimidine chemical structure, C17H9F6N3S, CAS 338418-06-7
2-(2-Pyridinyl)-4-(trifluoromethyl)-6-{[3-(trifluoromethyl)phenyl]sulfanyl}pyrimidine
CAS 338418-06-7C17H9F6N3S
4-[(2-Chlorophenyl)sulfanyl]-2-(2-pyridinyl)-5-pyrimidinyl methyl ether chemical structure, C16H12ClN3OS, CAS 338771-13-4
4-[(2-Chlorophenyl)sulfanyl]-2-(2-pyridinyl)-5-pyrimidinyl methyl ether
CAS 338771-13-4C16H12ClN3OS
4-(4-Chlorophenylthio)-2-(pyridin-2-yl)pyrimidine chemical structure, C15H10ClN3S, CAS 863581-72-0
4-(4-Chlorophenylthio)-2-(pyridin-2-yl)pyrimidine
CAS 863581-72-0C15H10ClN3S
4-[(3,4-Dichlorophenyl)thio]-2-(6-methylpyridin-2-yl)pyrimidine chemical structure, C16H11Cl2N3S, CAS 863581-95-7
4-[(3,4-Dichlorophenyl)thio]-2-(6-methylpyridin-2-yl)pyrimidine
CAS 863581-95-7C16H11Cl2N3S
2-(Pyridin-2-yl)-4-(m-tolylthio)pyrimidine chemical structure, C16H13N3S, CAS 863581-79-7
2-(Pyridin-2-yl)-4-(m-tolylthio)pyrimidine
CAS 863581-79-7C16H13N3S
4-(3-Chlorophenylthio)-2-(pyridin-2-yl)pyrimidine chemical structure, C15H10ClN3S, CAS 863581-71-9
4-(3-Chlorophenylthio)-2-(pyridin-2-yl)pyrimidine
CAS 863581-71-9C15H10ClN3S
4-(3-Bromophenylthio)-2-(pyridin-2-yl)pyrimidine chemical structure, C15H10BrN3S, CAS 863581-73-1
4-(3-Bromophenylthio)-2-(pyridin-2-yl)pyrimidine
CAS 863581-73-1C15H10BrN3S
4-(3,4-Dichloro-phenylsulfanyl)-2-pyridin-2-yl-pyrimidine chemical structure, C15H9Cl2N3S, CAS 863581-76-4
4-(3,4-Dichloro-phenylsulfanyl)-2-pyridin-2-yl-pyrimidine
CAS 863581-76-4C15H9Cl2N3S
2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-[(4-fluorophenyl)sulfanyl]pyrimidine chemical structure, C16H8ClF4N3S, CAS 2085690-39-5
2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-[(4-fluorophenyl)sulfanyl]pyrimidine
CAS 2085690-39-5C16H8ClF4N3S
2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-[(2-fluorophenyl)sulfanyl]pyrimidine chemical structure, C16H8ClF4N3S, CAS 2085690-48-6
2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-[(2-fluorophenyl)sulfanyl]pyrimidine
CAS 2085690-48-6C16H8ClF4N3S