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Murcko scaffold

Ring system with 3 rings and 19 atoms

21 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
21
With full pages
12
Scaffold SMILES

c1ccc(Oc2ccnc(-c3ccccn3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Oc2ccnc(-c3ccccn3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 21 of 21 chemicals

4-(2,4-Difluorophenoxy)-5-methoxy-2-(2-pyridinyl)pyrimidine chemical structure, C16H11F2N3O2, CAS 338771-61-2
4-(2,4-Difluorophenoxy)-5-methoxy-2-(2-pyridinyl)pyrimidine
CAS 338771-61-2C16H11F2N3O2
4-((Methylsulfanyl)methyl)-6-phenoxy-2-(2-pyridinyl)pyrimidine chemical structure, C17H15N3OS, CAS 477886-20-7
4-((Methylsulfanyl)methyl)-6-phenoxy-2-(2-pyridinyl)pyrimidine
CAS 477886-20-7C17H15N3OS
4-(2,6-Dimethylphenoxy)-5-methoxy-2-(2-pyridinyl)pyrimidine chemical structure, C18H17N3O2, CAS 338410-66-5
4-(2,6-Dimethylphenoxy)-5-methoxy-2-(2-pyridinyl)pyrimidine
CAS 338410-66-5C18H17N3O2
5-Methoxy-2-(2-pyridinyl)-4-pyrimidinyl 3-nitrophenyl ether chemical structure, C16H12N4O4, CAS 400081-22-3
5-Methoxy-2-(2-pyridinyl)-4-pyrimidinyl 3-nitrophenyl ether
CAS 400081-22-3C16H12N4O4
Phenyl 2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl ether chemical structure, C16H10F3N3O, CAS 338418-27-2
Phenyl 2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl ether
CAS 338418-27-2C16H10F3N3O
2-(2-Pyridinyl)-4-(trifluoromethyl)-6-[3-(trifluoromethyl)phenoxy]pyrimidine chemical structure, C17H9F6N3O, CAS 338418-28-3
2-(2-Pyridinyl)-4-(trifluoromethyl)-6-[3-(trifluoromethyl)phenoxy]pyrimidine
CAS 338418-28-3C17H9F6N3O
4-(4-Chlorophenoxy)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine chemical structure, C16H9ClF3N3O, CAS 338418-29-4
4-(4-Chlorophenoxy)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine
CAS 338418-29-4C16H9ClF3N3O
4-{[2-(2-Pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl]oxy}benzenecarbonitrile chemical structure, C17H9F3N4O, CAS 338754-15-7
4-{[2-(2-Pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl]oxy}benzenecarbonitrile
CAS 338754-15-7C17H9F3N4O
Methyl 2-{[2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl]oxy}benzenecarboxylate chemical structure, C18H12F3N3O3, CAS 338754-17-9
Methyl 2-{[2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl]oxy}benzenecarboxylate
CAS 338754-17-9C18H12F3N3O3
4-(2-Chlorophenoxy)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine chemical structure, C16H9ClF3N3O, CAS 338754-21-5
4-(2-Chlorophenoxy)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine
CAS 338754-21-5C16H9ClF3N3O
5-Methoxy-4-(4-methoxyphenoxy)-2-(2-pyridinyl)pyrimidine chemical structure, C17H15N3O3, CAS 338771-29-2
5-Methoxy-4-(4-methoxyphenoxy)-2-(2-pyridinyl)pyrimidine
CAS 338771-29-2C17H15N3O3
4-(3-Chlorophenoxy)-5-methoxy-2-(2-pyridinyl)pyrimidine chemical structure, C16H12ClN3O2, CAS 338771-31-6
4-(3-Chlorophenoxy)-5-methoxy-2-(2-pyridinyl)pyrimidine
CAS 338771-31-6C16H12ClN3O2
4-(4-Fluorophenoxy)-5-methoxy-2-(2-pyridinyl)pyrimidine chemical structure, C16H12FN3O2, CAS 338771-33-8
4-(4-Fluorophenoxy)-5-methoxy-2-(2-pyridinyl)pyrimidine
CAS 338771-33-8C16H12FN3O2
Methyl 2-{[5-methoxy-2-(2-pyridinyl)-4-pyrimidinyl]oxy}benzenecarboxylate chemical structure, C18H15N3O4, CAS 338771-35-0
Methyl 2-{[5-methoxy-2-(2-pyridinyl)-4-pyrimidinyl]oxy}benzenecarboxylate
CAS 338771-35-0C18H15N3O4
4-(3,5-Dichlorophenoxy)-5-methoxy-2-(2-pyridinyl)pyrimidine chemical structure, C16H11Cl2N3O2, CAS 338771-41-8
4-(3,5-Dichlorophenoxy)-5-methoxy-2-(2-pyridinyl)pyrimidine
CAS 338771-41-8C16H11Cl2N3O2
5-Methoxy-2-(2-pyridinyl)-4-pyrimidinyl 3-(trifluoromethyl)phenyl ether chemical structure, C17H12F3N3O2, CAS 338771-15-6
5-Methoxy-2-(2-pyridinyl)-4-pyrimidinyl 3-(trifluoromethyl)phenyl ether
CAS 338771-15-6C17H12F3N3O2
4-(2-Chlorophenoxy)-5-methoxy-2-(2-pyridinyl)pyrimidine chemical structure, C16H12ClN3O2, CAS 338771-27-0
4-(2-Chlorophenoxy)-5-methoxy-2-(2-pyridinyl)pyrimidine
CAS 338771-27-0C16H12ClN3O2
4-(4-Chlorophenoxy)-5-methoxy-2-(2-pyridinyl)pyrimidine chemical structure, C16H12ClN3O2, CAS 338771-25-8
4-(4-Chlorophenoxy)-5-methoxy-2-(2-pyridinyl)pyrimidine
CAS 338771-25-8C16H12ClN3O2
4-[4-(tert-Butyl)phenoxy]-2-(2-pyridinyl)-5-pyrimidinyl methyl ether chemical structure, C20H21N3O2, CAS 338771-23-6
4-[4-(tert-Butyl)phenoxy]-2-(2-pyridinyl)-5-pyrimidinyl methyl ether
CAS 338771-23-6C20H21N3O2
5-Methoxy-4-phenoxy-2-(2-pyridinyl)pyrimidine chemical structure, C16H13N3O2, CAS 338771-21-4
5-Methoxy-4-phenoxy-2-(2-pyridinyl)pyrimidine
CAS 338771-21-4C16H13N3O2
2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-(2-chlorophenoxy)pyrimidine chemical structure, C16H8Cl2F3N3O, CAS 2085690-37-3
2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-(2-chlorophenoxy)pyrimidine
CAS 2085690-37-3C16H8Cl2F3N3O