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Murcko scaffold

Ring system with 4 rings and 24 atoms

12 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
12
With full pages
3
Scaffold SMILES

O=C1N=C(N2CCOCC2)SC1=Cc1ccc(-c2ccccc2)o1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1N=C(N2CCOCC2)SC1=Cc1ccc(-c2ccccc2)o1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

(E)-2-Morpholino-5-((5-phenylfuran-2-yl)methylene)thiazol-4(5H)-one chemical structure, C18H16N2O3S, CAS 315241-84-0
(E)-2-Morpholino-5-((5-phenylfuran-2-yl)methylene)thiazol-4(5H)-one
CAS 315241-84-0C18H16N2O3S
(5E)-2-(Morpholin-4-yl)-5-{[5-(3-nitrophenyl)furan-2-yl]methylidene}-1,3-thiazol-4(5H)-one chemical structure, C18H15N3O5S, CAS 332023-20-8
(5E)-2-(Morpholin-4-yl)-5-{[5-(3-nitrophenyl)furan-2-yl]methylidene}-1,3-thiazol-4(5H)-one
CAS 332023-20-8C18H15N3O5S
(E)-2-Morpholino-5-((5-(o-tolyl)furan-2-yl)methylene)thiazol-4(5H)-one chemical structure, C19H18N2O3S, CAS 326617-74-7
(E)-2-Morpholino-5-((5-(o-tolyl)furan-2-yl)methylene)thiazol-4(5H)-one
CAS 326617-74-7C19H18N2O3S
(E)-2-Morpholino-5-((5-(2-nitrophenyl)furan-2-yl)methylene)thiazol-4(5H)-one chemical structure, C18H15N3O5S, CAS 374616-08-7
(E)-2-Morpholino-5-((5-(2-nitrophenyl)furan-2-yl)methylene)thiazol-4(5H)-one
CAS 374616-08-7C18H15N3O5S
(E)-5-((5-(4-Methoxyphenyl)furan-2-yl)methylene)-2-morpholinothiazol-4(5H)-one chemical structure, C19H18N2O4S, CAS 405920-56-1
(E)-5-((5-(4-Methoxyphenyl)furan-2-yl)methylene)-2-morpholinothiazol-4(5H)-one
CAS 405920-56-1C19H18N2O4S
(E)-5-((5-(2-Chlorophenyl)furan-2-yl)methylene)-2-morpholinothiazol-4(5H)-one chemical structure, C18H15ClN2O3S, CAS 1164460-48-3
(E)-5-((5-(2-Chlorophenyl)furan-2-yl)methylene)-2-morpholinothiazol-4(5H)-one
CAS 1164460-48-3C18H15ClN2O3S
(E)-5-((5-(4-Chlorophenyl)furan-2-yl)methylene)-2-morpholinothiazol-4(5H)-one chemical structure, C18H15ClN2O3S, CAS 405920-54-9
(E)-5-((5-(4-Chlorophenyl)furan-2-yl)methylene)-2-morpholinothiazol-4(5H)-one
CAS 405920-54-9C18H15ClN2O3S
(E)-2-Morpholino-5-((5-(p-tolyl)furan-2-yl)methylene)thiazol-4(5H)-one chemical structure, C19H18N2O3S, CAS 326617-64-5
(E)-2-Morpholino-5-((5-(p-tolyl)furan-2-yl)methylene)thiazol-4(5H)-one
CAS 326617-64-5C19H18N2O3S
5-((5-(2,5-DI-CL-PH)-2-Furyl)methylene)-2-(4-morpholinyl)-1,3-thiazol-4(5H)-one chemical structure, C18H14Cl2N2O3S, CAS 332109-72-5
5-((5-(2,5-DI-CL-PH)-2-Furyl)methylene)-2-(4-morpholinyl)-1,3-thiazol-4(5H)-one
CAS 332109-72-5C18H14Cl2N2O3S
(5E)-5-{[5-(3,4-Dichlorophenyl)furan-2-yl]methylidene}-2-(morpholin-4-yl)-1,3-thiazol-4(5H)-one chemical structure, C18H14Cl2N2O3S, CAS 573970-89-5
(5E)-5-{[5-(3,4-Dichlorophenyl)furan-2-yl]methylidene}-2-(morpholin-4-yl)-1,3-thiazol-4(5H)-one
CAS 573970-89-5C18H14Cl2N2O3S
(E)-5-((5-(2-Bromophenyl)furan-2-yl)methylene)-2-morpholinothiazol-4(5H)-one chemical structure, C18H15BrN2O3S, CAS 315241-85-1
(E)-5-((5-(2-Bromophenyl)furan-2-yl)methylene)-2-morpholinothiazol-4(5H)-one
CAS 315241-85-1C18H15BrN2O3S
(5Z)-2-(2,6-Dimethylmorpholin-4-yl)-5-({5-[3-(trifluoromethyl)phenyl]furan-2-yl}methylidene)-1,3-thiazol-4(5H)-one chemical structure, C21H19F3N2O3S, CAS 372969-96-5
(5Z)-2-(2,6-Dimethylmorpholin-4-yl)-5-({5-[3-(trifluoromethyl)phenyl]furan-2-yl}methylidene)-1,3-thiazol-4(5H)-one
CAS 372969-96-5C21H19F3N2O3S