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Murcko scaffold

Ring system with 4 rings and 25 atoms

14 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
14
With full pages
7
Scaffold SMILES

O=C1CC(Sc2n[nH]c(-c3ccccc3)n2)C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(Sc2n[nH]c(-c3ccccc3)n2)C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

3-{[5-(4-Methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-1-phenylpyrrolidine-2,5-dione chemical structure, C19H16N4O2S, CAS 371202-46-9
3-{[5-(4-Methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-1-phenylpyrrolidine-2,5-dione
CAS 371202-46-9C19H16N4O2S
1-(4-Ethoxyphenyl)-3-{[5-(3-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}pyrrolidine-2,5-dione chemical structure, C21H20N4O3S, CAS 488841-43-6
1-(4-Ethoxyphenyl)-3-{[5-(3-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}pyrrolidine-2,5-dione
CAS 488841-43-6C21H20N4O3S
1-(2-Ethoxyphenyl)-3-[(5-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyrrolidine-2,5-dione chemical structure, C20H18N4O3S, CAS 498535-52-7
1-(2-Ethoxyphenyl)-3-[(5-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyrrolidine-2,5-dione
CAS 498535-52-7C20H18N4O3S
1-(2-Methoxyphenyl)-3-{[5-(3-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}pyrrolidine-2,5-dione chemical structure, C20H18N4O3S, CAS 489404-41-3
1-(2-Methoxyphenyl)-3-{[5-(3-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}pyrrolidine-2,5-dione
CAS 489404-41-3C20H18N4O3S
1-(4-Ethoxyphenyl)-3-[(5-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]-2,5-pyrrolidinedione chemical structure, C20H18N4O3S, CAS 488128-67-2
1-(4-Ethoxyphenyl)-3-[(5-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]-2,5-pyrrolidinedione
CAS 488128-67-2C20H18N4O3S
1-(4-Fluorophenyl)-3-{[5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}pyrrolidine-2,5-dione chemical structure, C19H15FN4O3S, CAS 497244-93-6
1-(4-Fluorophenyl)-3-{[5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}pyrrolidine-2,5-dione
CAS 497244-93-6C19H15FN4O3S
1-(2,3-Dimethylphenyl)-3-{[5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}pyrrolidine-2,5-dione chemical structure, C21H20N4O3S, CAS 497243-28-4
1-(2,3-Dimethylphenyl)-3-{[5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}pyrrolidine-2,5-dione
CAS 497243-28-4C21H20N4O3S
1-(4-Methoxyphenyl)-3-{[5-(4-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}pyrrolidine-2,5-dione chemical structure, C20H18N4O3S, CAS 500145-26-6
1-(4-Methoxyphenyl)-3-{[5-(4-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}pyrrolidine-2,5-dione
CAS 500145-26-6C20H18N4O3S
1-(4-Methoxyphenyl)-3-{[5-(3-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}pyrrolidine-2,5-dione chemical structure, C20H18N4O3S, CAS 488854-34-8
1-(4-Methoxyphenyl)-3-{[5-(3-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}pyrrolidine-2,5-dione
CAS 488854-34-8C20H18N4O3S
3-{[5-(4-Methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-1-phenylpyrrolidine-2,5-dione chemical structure, C19H16N4O3S, CAS 489396-56-7
3-{[5-(4-Methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-1-phenylpyrrolidine-2,5-dione
CAS 489396-56-7C19H16N4O3S
1-(4-Chlorophenyl)-3-{[5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}pyrrolidine-2,5-dione chemical structure, C19H15ClN4O3S, CAS 488087-34-9
1-(4-Chlorophenyl)-3-{[5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}pyrrolidine-2,5-dione
CAS 488087-34-9C19H15ClN4O3S
1-(3-Fluorophenyl)-3-[(5-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyrrolidine-2,5-dione chemical structure, C18H13FN4O2S, CAS 672338-54-4
1-(3-Fluorophenyl)-3-[(5-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyrrolidine-2,5-dione
CAS 672338-54-4C18H13FN4O2S
1-(3,4-Dimethylphenyl)-3-[(5-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyrrolidine-2,5-dione chemical structure, C20H18N4O2S, CAS 674295-57-9
1-(3,4-Dimethylphenyl)-3-[(5-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyrrolidine-2,5-dione
CAS 674295-57-9C20H18N4O2S
1-(4-Methoxyphenyl)-3-[(5-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyrrolidine-2,5-dione chemical structure, C19H16N4O3S, CAS 488857-64-3
1-(4-Methoxyphenyl)-3-[(5-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyrrolidine-2,5-dione
CAS 488857-64-3C19H16N4O3S