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Murcko scaffold

Ring system with 4 rings and 24 atoms

32 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
32
With full pages
5
Scaffold SMILES

O=C1C(=Cc2ccc(-c3ccccc3)o2)C=NN1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=Cc2ccc(-c3ccccc3)o2)C=NN1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

2-Chloro-5-[(4Z)-5-oxo-4-[(5-phenylfuran-2-yl)methylidene]-3-(trifluoromethyl)pyrazol-1-yl]benzoic acid chemical structure, C22H12ClF3N2O4, CAS 496807-64-8
2-Chloro-5-[(4Z)-5-oxo-4-[(5-phenylfuran-2-yl)methylidene]-3-(trifluoromethyl)pyrazol-1-yl]benzoic acid
CAS 496807-64-8C22H12ClF3N2O4
(4E)-5-Methyl-4-{[5-(2-nitrophenyl)furan-2-yl]methylidene}-2-phenyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C21H15N3O4, CAS 1322000-08-7
(4E)-5-Methyl-4-{[5-(2-nitrophenyl)furan-2-yl]methylidene}-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
CAS 1322000-08-7C21H15N3O4
4-[(4E)-4-({5-[4-Chloro-3-(ethoxycarbonyl)phenyl]furan-2-yl}methylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid chemical structure, C25H19ClN2O6, CAS 313701-89-2
4-[(4E)-4-({5-[4-Chloro-3-(ethoxycarbonyl)phenyl]furan-2-yl}methylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid
CAS 313701-89-2C25H19ClN2O6
3-[(4Z)-4-[[5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid chemical structure, C24H19N3O6, CAS 5838-07-3
3-[(4Z)-4-[[5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
CAS 5838-07-3C24H19N3O6
3-(5-{(Z)-[1-(4-Chlorophenyl)-5-oxo-3-(trifluoromethyl)-1,5-dihydro-4H-pyrazol-4-ylidene]methyl}furan-2-yl)benzoic acid chemical structure, C22H12ClF3N2O4, CAS 432512-36-2
3-(5-{(Z)-[1-(4-Chlorophenyl)-5-oxo-3-(trifluoromethyl)-1,5-dihydro-4H-pyrazol-4-ylidene]methyl}furan-2-yl)benzoic acid
CAS 432512-36-2C22H12ClF3N2O4
4-[(4Z)-4-{[5-(3-Chlorophenyl)furan-2-yl]methylidene}-5-oxo-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid chemical structure, C22H12ClF3N2O4, CAS 433262-55-6
4-[(4Z)-4-{[5-(3-Chlorophenyl)furan-2-yl]methylidene}-5-oxo-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid
CAS 433262-55-6C22H12ClF3N2O4
4-[(4Z)-4-{[5-(4-Carboxyphenyl)furan-2-yl]methylidene}-5-oxo-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid chemical structure, C23H13F3N2O6, CAS 1668604-55-4
4-[(4Z)-4-{[5-(4-Carboxyphenyl)furan-2-yl]methylidene}-5-oxo-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid
CAS 1668604-55-4C23H13F3N2O6
3-[(4Z)-3-Methyl-4-[[5-(4-methyl-2-nitrophenyl)furan-2-yl]methylidene]-5-oxopyrazol-1-yl]benzoic acid chemical structure, C23H17N3O6, CAS 343355-63-5
3-[(4Z)-3-Methyl-4-[[5-(4-methyl-2-nitrophenyl)furan-2-yl]methylidene]-5-oxopyrazol-1-yl]benzoic acid
CAS 343355-63-5C23H17N3O6
Ethyl 4-[(4Z)-4-{[5-(3-nitrophenyl)furan-2-yl]methylidene}-5-oxo-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl]benzoate chemical structure, C24H16F3N3O6, CAS 431924-35-5
Ethyl 4-[(4Z)-4-{[5-(3-nitrophenyl)furan-2-yl]methylidene}-5-oxo-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl]benzoate
CAS 431924-35-5C24H16F3N3O6
(4Z)-2-(4-Chlorophenyl)-4-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-5-(trifluoromethyl)pyrazol-3-one chemical structure, C21H11ClF3N3O4, CAS 431992-55-1
(4Z)-2-(4-Chlorophenyl)-4-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-5-(trifluoromethyl)pyrazol-3-one
CAS 431992-55-1C21H11ClF3N3O4
(4Z)-2-(4-Chlorophenyl)-4-[[5-(4-chlorophenyl)furan-2-yl]methylidene]-5-(trifluoromethyl)pyrazol-3-one chemical structure, C21H11Cl2F3N2O2, CAS 432537-58-1
(4Z)-2-(4-Chlorophenyl)-4-[[5-(4-chlorophenyl)furan-2-yl]methylidene]-5-(trifluoromethyl)pyrazol-3-one
CAS 432537-58-1C21H11Cl2F3N2O2
4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid chemical structure, C24H19N3O6, CAS 328968-36-1
4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid
CAS 328968-36-1C24H19N3O6
4-{[5-(4-Bromo-3-nitrophenyl)furan-2-yl]methylidene}-2-(3-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C21H13BrClN3O4, CAS 4443-41-8
4-{[5-(4-Bromo-3-nitrophenyl)furan-2-yl]methylidene}-2-(3-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one
CAS 4443-41-8C21H13BrClN3O4
(E)-1-(3-Chlorophenyl)-3-methyl-4-((5-(2-nitrophenyl)furan-2-yl)methylene)-1H-pyrazol-5(4H)-one chemical structure, C21H14ClN3O4, CAS 5843-00-5
(E)-1-(3-Chlorophenyl)-3-methyl-4-((5-(2-nitrophenyl)furan-2-yl)methylene)-1H-pyrazol-5(4H)-one
CAS 5843-00-5C21H14ClN3O4
2-Chloro-5-(5-{(E)-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]methyl}furan-2-yl)benzoic acid chemical structure, C24H19ClN2O4, CAS 321531-16-2
2-Chloro-5-(5-{(E)-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]methyl}furan-2-yl)benzoic acid
CAS 321531-16-2C24H19ClN2O4
RefChem:314135 chemical structure, C23H15ClN2O6, CAS 292065-64-6
RefChem:314135
CAS 292065-64-6C23H15ClN2O6
(Z)-Ethyl 4-(5-((3-methyl-5-oxo-1-(4-sulfamoylphenyl)-1H-pyrazol-4(5H)-ylidene)methyl)furan-2-yl)benzoate chemical structure, C24H21N3O6S, CAS 380551-95-1
(Z)-Ethyl 4-(5-((3-methyl-5-oxo-1-(4-sulfamoylphenyl)-1H-pyrazol-4(5H)-ylidene)methyl)furan-2-yl)benzoate
CAS 380551-95-1C24H21N3O6S
3-[(4Z)-4-{[5-(2-Methoxy-4-nitrophenyl)furan-2-yl]methylidene}-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid chemical structure, C23H17N3O7, CAS 292065-71-5
3-[(4Z)-4-{[5-(2-Methoxy-4-nitrophenyl)furan-2-yl]methylidene}-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid
CAS 292065-71-5C23H17N3O7
4-[(4E)-4-[[5-(2,4-Dichlorophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzenesulfonamide chemical structure, C21H15Cl2N3O4S, CAS 424808-28-6
4-[(4E)-4-[[5-(2,4-Dichlorophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzenesulfonamide
CAS 424808-28-6C21H15Cl2N3O4S
Methyl 2-[5-[(E)-(3-methyl-5-oxo-1-phenylpyrazol-4-ylidene)methyl]furan-2-yl]benzoate chemical structure, C23H18N2O4, CAS 299905-74-1
Methyl 2-[5-[(E)-(3-methyl-5-oxo-1-phenylpyrazol-4-ylidene)methyl]furan-2-yl]benzoate
CAS 299905-74-1C23H18N2O4
Methyl 4-[5-[(Z)-[3-methyl-5-oxo-1-(4-sulfamoylphenyl)pyrazol-4-ylidene]methyl]furan-2-yl]benzoate chemical structure, C23H19N3O6S, CAS 353503-76-1
Methyl 4-[5-[(Z)-[3-methyl-5-oxo-1-(4-sulfamoylphenyl)pyrazol-4-ylidene]methyl]furan-2-yl]benzoate
CAS 353503-76-1C23H19N3O6S
4-(5-{(Z)-[1-(4-Fluorophenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]methyl}furan-2-yl)benzoic acid chemical structure, C22H15FN2O4, CAS 353503-95-4
4-(5-{(Z)-[1-(4-Fluorophenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]methyl}furan-2-yl)benzoic acid
CAS 353503-95-4C22H15FN2O4
4-[(4Z)-3-Methyl-5-oxo-4-({5-[3-(trifluoromethyl)phenyl]furan-2-yl}methylidene)-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid chemical structure, C23H15F3N2O4, CAS 1668604-47-4
4-[(4Z)-3-Methyl-5-oxo-4-({5-[3-(trifluoromethyl)phenyl]furan-2-yl}methylidene)-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid
CAS 1668604-47-4C23H15F3N2O4
(4Z)-4-[[5-(2-Methoxy-5-nitrophenyl)furan-2-yl]methylidene]-5-methyl-2-phenylpyrazol-3-one chemical structure, C22H17N3O5, CAS 433307-78-9
(4Z)-4-[[5-(2-Methoxy-5-nitrophenyl)furan-2-yl]methylidene]-5-methyl-2-phenylpyrazol-3-one
CAS 433307-78-9C22H17N3O5