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Murcko scaffold

Ring system with 4 rings and 25 atoms

31 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 25
Chemicals: 31
With full pages: 2

Scaffold SMILES

O=C1C(=Cc2ccc(-c3ccccc3)o2)SC(=S)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1C(=Cc2ccc(-c3ccccc3)o2)SC(=S)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 31 of 31 chemicals

5-{[5-(4-Acetylphenyl)-2-furyl]methylene}-3-phenyl-2-thioxo-1,3-thiazolidin-4-one chemical structure, C22H15NO3S2, CAS 5377-41-3

5-{[5-(4-Acetylphenyl)-2-furyl]methylene}-3-phenyl-2-thioxo-1,3-thiazolidin-4-one

CAS 5377-41-3C₂₂H₁₅NO₃S₂

3-(4-Methoxyphenyl)-5-[(5-phenylfuran-2-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C21H15NO3S2, CAS 354560-90-0

3-(4-Methoxyphenyl)-5-[(5-phenylfuran-2-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 354560-90-0C₂₁H₁₅NO₃S₂

(5E)-3-(4-Chlorophenyl)-5-[[5-(3-nitrophenyl)furan-2-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H11ClN2O4S2, CAS 292168-11-7

(5E)-3-(4-Chlorophenyl)-5-[[5-(3-nitrophenyl)furan-2-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 292168-11-7C₂₀H₁₁ClN₂O₄S₂

Methyl 2-[5-[(E)-(4-oxo-3-phenyl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl]benzoate chemical structure, C22H15NO4S2, CAS 299909-06-1

Methyl 2-[5-[(E)-(4-oxo-3-phenyl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl]benzoate

CAS 299909-06-1C₂₂H₁₅NO₄S₂

(5E)-5-[[5-(2-Methoxy-4-nitrophenyl)furan-2-yl]methylidene]-3-phenyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C21H14N2O5S2, CAS 299910-86-4

(5E)-5-[[5-(2-Methoxy-4-nitrophenyl)furan-2-yl]methylidene]-3-phenyl-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 299910-86-4C₂₁H₁₄N₂O₅S₂

(E)-5-((5-(4-Bromophenyl)furan-2-yl)methylene)-3-(3-hydroxyphenyl)-2-thioxothiazolidin-4-one chemical structure, C20H12BrNO3S2, CAS 423726-81-2

(E)-5-((5-(4-Bromophenyl)furan-2-yl)methylene)-3-(3-hydroxyphenyl)-2-thioxothiazolidin-4-one

CAS 423726-81-2C₂₀H₁₂BrNO₃S₂

(5Z)-5-{[5-(4-Bromophenyl)furan-2-yl]methylidene}-3-(3-chlorophenyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C20H11BrClNO2S2, CAS 309945-16-2

(5Z)-5-{[5-(4-Bromophenyl)furan-2-yl]methylidene}-3-(3-chlorophenyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 309945-16-2C₂₀H₁₁BrClNO₂S₂

(5E)-5-[[5-(3-Chloro-4-nitrophenyl)furan-2-yl]methylidene]-3-(4-methoxyphenyl)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C21H13ClN2O5S2, CAS 292169-46-1

(5E)-5-[[5-(3-Chloro-4-nitrophenyl)furan-2-yl]methylidene]-3-(4-methoxyphenyl)-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 292169-46-1C₂₁H₁₃ClN₂O₅S₂

(5E)-5-[[5-(2-Chloro-4-nitrophenyl)furan-2-yl]methylidene]-3-(4-chlorophenyl)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H10Cl2N2O4S2, CAS 292168-10-6

(5E)-5-[[5-(2-Chloro-4-nitrophenyl)furan-2-yl]methylidene]-3-(4-chlorophenyl)-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 292168-10-6C₂₀H₁₀Cl₂N₂O₄S₂

(E)-5-((5-(2-Chlorophenyl)furan-2-yl)methylene)-2-thioxo-3-(p-tolyl)thiazolidin-4-one chemical structure, C21H14ClNO2S2, CAS 851303-72-5

(E)-5-((5-(2-Chlorophenyl)furan-2-yl)methylene)-2-thioxo-3-(p-tolyl)thiazolidin-4-one

CAS 851303-72-5C₂₁H₁₄ClNO₂S₂

(5Z)-5-({5-[2-Chloro-5-(trifluoromethyl)phenyl]furan-2-yl}methylidene)-3-(4-methoxyphenyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C22H13ClF3NO3S2, CAS 342391-28-0

(5Z)-5-({5-[2-Chloro-5-(trifluoromethyl)phenyl]furan-2-yl}methylidene)-3-(4-methoxyphenyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 342391-28-0C₂₂H₁₃ClF₃NO₃S₂

(5E)-3-(3-Methylphenyl)-5-((5-(2-nitrophenyl)-2-furyl)methylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C21H14N2O4S2, CAS 312935-62-9

(5E)-3-(3-Methylphenyl)-5-((5-(2-nitrophenyl)-2-furyl)methylene)-2-thioxo-1,3-thiazolidin-4-one

CAS 312935-62-9C₂₁H₁₄N₂O₄S₂

(5E)-5-[[5-(2-Chloro-5-nitrophenyl)furan-2-yl]methylidene]-3-(4-methoxyphenyl)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C21H13ClN2O5S2, CAS 387873-32-7

(5E)-5-[[5-(2-Chloro-5-nitrophenyl)furan-2-yl]methylidene]-3-(4-methoxyphenyl)-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 387873-32-7C₂₁H₁₃ClN₂O₅S₂

(5E)-5-[[5-(2-Chlorophenyl)furan-2-yl]methylidene]-3-phenyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H12ClNO2S2, CAS 313238-35-6

(5E)-5-[[5-(2-Chlorophenyl)furan-2-yl]methylidene]-3-phenyl-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 313238-35-6C₂₀H₁₂ClNO₂S₂

2-Chloro-5-(5-{(E)-[3-(2,4-dimethylphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}furan-2-yl)benzoic acid chemical structure, C23H16ClNO4S2, CAS 433238-70-1

2-Chloro-5-(5-{(E)-[3-(2,4-dimethylphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}furan-2-yl)benzoic acid

CAS 433238-70-1C₂₃H₁₆ClNO₄S₂

(5E)-5-[[5-(4-Chloro-2-nitrophenyl)furan-2-yl]methylidene]-3-phenyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H11ClN2O4S2, CAS 433313-44-1

(5E)-5-[[5-(4-Chloro-2-nitrophenyl)furan-2-yl]methylidene]-3-phenyl-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 433313-44-1C₂₀H₁₁ClN₂O₄S₂

2-Methyl-3-{5-[(E)-{4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]furan-2-yl}benzoic acid chemical structure, C23H14F3NO4S2, CAS 433702-20-6

2-Methyl-3-{5-[(E)-{4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]furan-2-yl}benzoic acid

CAS 433702-20-6C₂₃H₁₄F₃NO₄S₂

(E)-2-(5-((4-Oxo-3-phenyl-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid chemical structure, C21H13NO4S2, CAS 387873-79-2

(E)-2-(5-((4-Oxo-3-phenyl-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid

CAS 387873-79-2C₂₁H₁₃NO₄S₂

Ethyl 4-(5-{(Z)-[3-(4-methylphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}furan-2-yl)benzoate chemical structure, C24H19NO4S2, CAS 434304-47-9

Ethyl 4-(5-{(Z)-[3-(4-methylphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}furan-2-yl)benzoate

CAS 434304-47-9C₂₄H₁₉NO₄S₂

(5Z)-5-{[5-(2,3-Dichlorophenyl)furan-2-yl]methylidene}-3-phenyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H11Cl2NO2S2, CAS 312926-07-1

(5Z)-5-{[5-(2,3-Dichlorophenyl)furan-2-yl]methylidene}-3-phenyl-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 312926-07-1C₂₀H₁₁Cl₂NO₂S₂

3-[5-[(Z)-[3-(3-Fluorophenyl)-4-oxo-2-thioxo-thiazolidin-5-ylidene]methyl]-2-furyl]benzoic acid chemical structure, C21H12FNO4S2, CAS 691881-70-6

3-[5-[(Z)-[3-(3-Fluorophenyl)-4-oxo-2-thioxo-thiazolidin-5-ylidene]methyl]-2-furyl]benzoic acid

CAS 691881-70-6C₂₁H₁₂FNO₄S₂

5-((5-(3-Nitrophenyl)-2-furyl)methylene)-3-phenyl-2-thioxo-1,3-thiazolidin-4-one chemical structure, C20H12N2O4S2, CAS 327038-04-0

5-((5-(3-Nitrophenyl)-2-furyl)methylene)-3-phenyl-2-thioxo-1,3-thiazolidin-4-one

CAS 327038-04-0C₂₀H₁₂N₂O₄S₂

3-(5-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid chemical structure, C22H12F3NO4S2, CAS 1262518-84-2

3-(5-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid

CAS 1262518-84-2C₂₂H₁₂F₃NO₄S₂

(E)-5-((5-(2,4-Dichlorophenyl)furan-2-yl)methylene)-3-(4-methoxyphenyl)-2-thioxothiazolidin-4-one chemical structure, C21H13Cl2NO3S2, CAS 851304-20-6

(E)-5-((5-(2,4-Dichlorophenyl)furan-2-yl)methylene)-3-(4-methoxyphenyl)-2-thioxothiazolidin-4-one

CAS 851304-20-6C₂₁H₁₃Cl₂NO₃S₂