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Murcko scaffold

Ring system with 4 rings and 24 atoms

13 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 24
Chemicals: 13
With full pages: 2

Scaffold SMILES

O=c1c(N=c2[nH]c(-c3ccccc3)cs2)c[nH]n1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1c(N=c2[nH]c(-c3ccccc3)cs2)c[nH]n1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

(Z)-4-((3-(2-Hydroxyethyl)-4-(p-tolyl)thiazol-2(3H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one chemical structure, C23H24N4O2S, CAS 298206-49-2

(Z)-4-((3-(2-Hydroxyethyl)-4-(p-tolyl)thiazol-2(3H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one

CAS 298206-49-2C₂₃H₂₄N₄O₂S

4-{[(2E)-3-Allyl-4-(4-methoxyphenyl)-1,3-thiazol-2(3H)-ylidene]amino}-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one chemical structure, C24H24N4O2S, CAS 298206-54-9

4-{[(2E)-3-Allyl-4-(4-methoxyphenyl)-1,3-thiazol-2(3H)-ylidene]amino}-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one

CAS 298206-54-9C₂₄H₂₄N₄O₂S

4-[(3-tert-Butyl-4-(4-methoxyphenyl)-1,3-thiazol-2(3H)-ylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one chemical structure, C25H28N4O2S, CAS 1164561-76-5

4-[(3-tert-Butyl-4-(4-methoxyphenyl)-1,3-thiazol-2(3H)-ylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one

CAS 1164561-76-5C₂₅H₂₈N₄O₂S

(Z)-4-((3-Allyl-4-(p-tolyl)thiazol-2(3H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one chemical structure, C24H24N4OS, CAS 292056-63-4

(Z)-4-((3-Allyl-4-(p-tolyl)thiazol-2(3H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one

CAS 292056-63-4C₂₄H₂₄N₄OS

(Z)-4-((3-Allyl-4-phenylthiazol-2(3H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one chemical structure, C23H22N4OS, CAS 298206-50-5

(Z)-4-((3-Allyl-4-phenylthiazol-2(3H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one

CAS 298206-50-5C₂₃H₂₂N₄OS

(Z)-4-((3-Allyl-4-(4-nitrophenyl)thiazol-2(3H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one chemical structure, C23H21N5O3S, CAS 298206-52-7

(Z)-4-((3-Allyl-4-(4-nitrophenyl)thiazol-2(3H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one

CAS 298206-52-7C₂₃H₂₁N₅O₃S

4-[(3-tert-Butyl-4-phenyl-1,3-thiazol-2(3H)-ylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one chemical structure, C24H26N4OS, CAS 307325-31-1

4-[(3-tert-Butyl-4-phenyl-1,3-thiazol-2(3H)-ylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one

CAS 307325-31-1C₂₄H₂₆N₄OS

(Z)-4-((3-(tert-Butyl)-4-(p-tolyl)thiazol-2(3H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one chemical structure, C25H28N4OS, CAS 324577-91-5

(Z)-4-((3-(tert-Butyl)-4-(p-tolyl)thiazol-2(3H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one

CAS 324577-91-5C₂₅H₂₈N₄OS

(Z)-4-((3-Allyl-4-(p-tolyl)thiazol-2(3H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one hydrobromide chemical structure, C24H25BrN4OS, CAS 1093253-40-7

(Z)-4-((3-Allyl-4-(p-tolyl)thiazol-2(3H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one hydrobromide

CAS 1093253-40-7C₂₄H₂₅BrN₄OS

(Z)-4-((3-Allyl-4-phenylthiazol-2(3H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one hydrobromide chemical structure, C23H23BrN4OS, CAS 294183-32-7

(Z)-4-((3-Allyl-4-phenylthiazol-2(3H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one hydrobromide

CAS 294183-32-7C₂₃H₂₃BrN₄OS

(Z)-4-((3-Allyl-4-(3,4-dichlorophenyl)thiazol-2(3H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one hydrobromide chemical structure, C23H21BrCl2N4OS, CAS 479351-91-2

(Z)-4-((3-Allyl-4-(3,4-dichlorophenyl)thiazol-2(3H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one hydrobromide

CAS 479351-91-2C₂₃H₂₁BrCl₂N₄OS

(Z)-4-((3-(tert-Butyl)-4-(3-nitrophenyl)thiazol-2(3H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one hydrobromide chemical structure, C24H26BrN5O3S, CAS 352018-54-3

(Z)-4-((3-(tert-Butyl)-4-(3-nitrophenyl)thiazol-2(3H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one hydrobromide

CAS 352018-54-3C₂₄H₂₆BrN₅O₃S

4-{[(2Z)-4-(4-Chlorophenyl)-3-(2-hydroxyethyl)-2,3-dihydro-1,3-thiazol-2-ylidene]amino}-1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one, ethanol chemical structure, C24H27ClN4O3S, CAS 474877-84-4

4-{[(2Z)-4-(4-Chlorophenyl)-3-(2-hydroxyethyl)-2,3-dihydro-1,3-thiazol-2-ylidene]amino}-1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one, ethanol

CAS 474877-84-4C₂₄H₂₇ClN₄O₃S