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Murcko scaffold

Ring system with 4 rings and 23 atoms

17 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 23
Chemicals: 17
With full pages: 8

Scaffold SMILES

C(=C1NC(c2ccccc2)CO1)C1=NC(c2ccccc2)CO1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold C(=C1NC(c2ccccc2)CO1)C1=NC(c2ccccc2)CO1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

2-(4-Phenyl-4,5-dihydro-1,3-oxazol-2-yl)-2-(4-phenyl-1,3-oxazolidin-2-ylidene)acetonitrile chemical structure, C20H17N3O2

2-(4-Phenyl-4,5-dihydro-1,3-oxazol-2-yl)-2-(4-phenyl-1,3-oxazolidin-2-ylidene)acetonitrile

C₂₀H₁₇N₃O₂

(E)-2-((R)-4-Phenyl-4,5-dihydrooxazol-2-yl)-2-((R)-4-phenyloxazolidin-2-ylidene)acetonitrile chemical structure, C20H17N3O2, CAS 1842387-08-9

(E)-2-((R)-4-Phenyl-4,5-dihydrooxazol-2-yl)-2-((R)-4-phenyloxazolidin-2-ylidene)acetonitrile

CAS 1842387-08-9C₂₀H₁₇N₃O₂

(E)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)-2-(4-phenyloxazolidin-2-ylidene)acetonitrile chemical structure, C20H17N3O2, CAS 2377912-44-0

(E)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)-2-(4-phenyloxazolidin-2-ylidene)acetonitrile

CAS 2377912-44-0C₂₀H₁₇N₃O₂

(AlphaE,4S)-4,5-dihydro-4-phenyl-alpha-[(4S)-4-phenyl-2-oxazolidinylidene]-2-oxazoleacetonitrile chemical structure, C20H17N3O2, CAS 178230-18-7

(AlphaE,4S)-4,5-dihydro-4-phenyl-alpha-[(4S)-4-phenyl-2-oxazolidinylidene]-2-oxazoleacetonitrile

CAS 178230-18-7C₂₀H₁₇N₃O₂

(E)-2-((R)-5,5-Dimethyl-4-phenyl-4,5-dihydrooxazol-2-yl)-2-((R)-5,5-dimethyl-4-phenyloxazolidin-2-ylidene)acetonitrile chemical structure, C24H25N3O2, CAS 767332-20-7

(E)-2-((R)-5,5-Dimethyl-4-phenyl-4,5-dihydrooxazol-2-yl)-2-((R)-5,5-dimethyl-4-phenyloxazolidin-2-ylidene)acetonitrile

CAS 767332-20-7C₂₄H₂₅N₃O₂

(4S)-(+)-4-[4-(tert-Butyl)phenyl]-alpha-[(4S)-4-[4-(tert-butyl)phenyl]-2-oxazolidinylidene]-2-oxazolineacetonitrile chemical structure, C28H33N3O2, CAS 1217481-09-8

(4S)-(+)-4-[4-(tert-Butyl)phenyl]-alpha-[(4S)-4-[4-(tert-butyl)phenyl]-2-oxazolidinylidene]-2-oxazolineacetonitrile

CAS 1217481-09-8C₂₈H₃₃N₃O₂

(2Z)-[(4S)-4-Phenyl-4,5-dihydro-1,3-oxazol-2-yl][(4S)-4-phenyl-1,3-oxazolidin-2-ylidene]acetonitrile chemical structure, C20H17N3O2, CAS 150639-33-1

(2Z)-[(4S)-4-Phenyl-4,5-dihydro-1,3-oxazol-2-yl][(4S)-4-phenyl-1,3-oxazolidin-2-ylidene]acetonitrile

CAS 150639-33-1C₂₀H₁₇N₃O₂

(E)-2-((S)-4-(4-(tert-Butyl)phenyl)-4,5-dihydrooxazol-2-yl)-2-((S)-4-(4-(tert-butyl)phenyl)oxazolidin-2-ylidene)acetonitrile chemical structure, C28H33N3O2

(E)-2-((S)-4-(4-(tert-Butyl)phenyl)-4,5-dihydrooxazol-2-yl)-2-((S)-4-(4-(tert-butyl)phenyl)oxazolidin-2-ylidene)acetonitrile

C₂₈H₃₃N₃O₂

(4S)-(+)-Phenyl-alpha-[(4S)-phenyloxazolidin-2-ylidene]-2-oxazoline-2-acetonitrile chemical structure, C20H17N3O2

(4S)-(+)-Phenyl-alpha-[(4S)-phenyloxazolidin-2-ylidene]-2-oxazoline-2-acetonitrile

C₂₀H₁₇N₃O₂

Bis[(4S)-4-(4-tert-butylphenyl)-4,5-dihydro-2-oxazolyl]acetonitrile chemical structure, C28H33N3O2

Bis[(4S)-4-(4-tert-butylphenyl)-4,5-dihydro-2-oxazolyl]acetonitrile

C₂₈H₃₃N₃O₂

2-[4-(4-tert-Butylphenyl)-4,5-dihydro-1,3-oxazol-2-yl]-2-[4-(4-tert-butylphenyl)-1,3-oxazolidin-2-ylidene]acetonitrile chemical structure, C28H33N3O2

2-[4-(4-tert-Butylphenyl)-4,5-dihydro-1,3-oxazol-2-yl]-2-[4-(4-tert-butylphenyl)-1,3-oxazolidin-2-ylidene]acetonitrile

C₂₈H₃₃N₃O₂

(E)-2-((R)-4-(3,5-di-tert-Butylphenyl)-4,5-dihydrooxazol-2-yl)-2-((R)-4-(3,5-di-tert-butylphenyl)oxazolidin-2-ylidene)acetonitrile chemical structure, C36H49N3O2, CAS 1872424-89-9

(E)-2-((R)-4-(3,5-di-tert-Butylphenyl)-4,5-dihydrooxazol-2-yl)-2-((R)-4-(3,5-di-tert-butylphenyl)oxazolidin-2-ylidene)acetonitrile

CAS 1872424-89-9C₃₆H₄₉N₃O₂

2-((R)-4-(4-(tert-Butyl)phenyl)-4,5-dihydrooxazol-2-yl)-2-((R)-4-(4-(tert-butyl)phenyl)oxazolidin-2-ylidene)acetonitrile chemical structure, C28H33N3O2, CAS 866540-35-4

2-((R)-4-(4-(tert-Butyl)phenyl)-4,5-dihydrooxazol-2-yl)-2-((R)-4-(4-(tert-butyl)phenyl)oxazolidin-2-ylidene)acetonitrile

CAS 866540-35-4C₂₈H₃₃N₃O₂

(E)-2-((S)-4-(3,5-di-tert-Butylphenyl)-4,5-dihydrooxazol-2-yl)-2-((S)-4-(3,5-di-tert-butylphenyl)oxazolidin-2-ylidene)acetonitrile chemical structure, C36H49N3O2, CAS 1872424-68-4

(E)-2-((S)-4-(3,5-di-tert-Butylphenyl)-4,5-dihydrooxazol-2-yl)-2-((S)-4-(3,5-di-tert-butylphenyl)oxazolidin-2-ylidene)acetonitrile

CAS 1872424-68-4C₃₆H₄₉N₃O₂

(E)-2-((S)-4-(4-Fluorophenyl)-4,5-dihydrooxazol-2-yl)-2-((S)-4-(4-fluorophenyl)oxazolidin-2-ylidene)acetonitrile chemical structure, C20H15F2N3O2, CAS 2755243-66-2

(E)-2-((S)-4-(4-Fluorophenyl)-4,5-dihydrooxazol-2-yl)-2-((S)-4-(4-fluorophenyl)oxazolidin-2-ylidene)acetonitrile

CAS 2755243-66-2C₂₀H₁₅F₂N₃O₂

(E)-2-((R)-4-(4-(tert-Butyl)phenyl)-4,5-dihydrooxazol-2-yl)-2-((R)-4-(4-(tert-butyl)phenyl)oxazolidin-2-ylidene)acetonitrile chemical structure, C28H33N3O2, CAS 1872424-67-3

(E)-2-((R)-4-(4-(tert-Butyl)phenyl)-4,5-dihydrooxazol-2-yl)-2-((R)-4-(4-(tert-butyl)phenyl)oxazolidin-2-ylidene)acetonitrile

CAS 1872424-67-3C₂₈H₃₃N₃O₂

(E)-2-((S)-5,5-Dimethyl-4-phenyl-4,5-dihydrooxazol-2-yl)-2-((S)-5,5-dimethyl-4-phenyloxazolidin-2-ylidene)acetonitrile chemical structure, C24H25N3O2, CAS 767332-21-8

(E)-2-((S)-5,5-Dimethyl-4-phenyl-4,5-dihydrooxazol-2-yl)-2-((S)-5,5-dimethyl-4-phenyloxazolidin-2-ylidene)acetonitrile

CAS 767332-21-8C₂₄H₂₅N₃O₂