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Murcko scaffold

Ring system with 3 rings and 16 atoms

16 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
16
With full pages
4
Scaffold SMILES

c1ccc(-c2noc(-c3cc[nH]n3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2noc(-c3cc[nH]n3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

3-(4-Chlorophenyl)-5-(3-isopropyl-1H-pyrazol-5-yl)-1,2,4-oxadiazole chemical structure, C14H13ClN4O, CAS 1351355-23-1
3-(4-Chlorophenyl)-5-(3-isopropyl-1H-pyrazol-5-yl)-1,2,4-oxadiazole
CAS 1351355-23-1C14H13ClN4O
3-(2,3-Dimethoxyphenyl)-5-(3-isopropyl-1H-pyrazol-5-yl)-1,2,4-oxadiazole chemical structure, C16H18N4O3, CAS 1037176-34-3
3-(2,3-Dimethoxyphenyl)-5-(3-isopropyl-1H-pyrazol-5-yl)-1,2,4-oxadiazole
CAS 1037176-34-3C16H18N4O3
3-(4-Bromophenyl)-5-(3-isopropyl-1H-pyrazol-5-yl)-1,2,4-oxadiazole chemical structure, C14H13BrN4O, CAS 1037176-35-4
3-(4-Bromophenyl)-5-(3-isopropyl-1H-pyrazol-5-yl)-1,2,4-oxadiazole
CAS 1037176-35-4C14H13BrN4O
5-(3-Isopropyl-1H-pyrazol-5-yl)-3-(m-tolyl)-1,2,4-oxadiazole chemical structure, C15H16N4O, CAS 1037192-90-7
5-(3-Isopropyl-1H-pyrazol-5-yl)-3-(m-tolyl)-1,2,4-oxadiazole
CAS 1037192-90-7C15H16N4O
5-(3-Isopropyl-1H-pyrazol-5-yl)-3-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazole chemical structure, C17H20N4O4, CAS 1037192-98-5
5-(3-Isopropyl-1H-pyrazol-5-yl)-3-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazole
CAS 1037192-98-5C17H20N4O4
5-(3-Methyl-1H-pyrazol-5-yl)-3-(o-tolyl)-1,2,4-oxadiazole chemical structure, C13H12N4O, CAS 1187345-87-4
5-(3-Methyl-1H-pyrazol-5-yl)-3-(o-tolyl)-1,2,4-oxadiazole
CAS 1187345-87-4C13H12N4O
5-(3-Methyl-1H-pyrazol-5-yl)-3-(4-methylphenyl)-1,2,4-oxadiazole chemical structure, C13H12N4O, CAS 1107541-95-6
5-(3-Methyl-1H-pyrazol-5-yl)-3-(4-methylphenyl)-1,2,4-oxadiazole
CAS 1107541-95-6C13H12N4O
3-(2-Chlorophenyl)-5-(3-methyl-1H-pyrazol-5-yl)-1,2,4-oxadiazole chemical structure, C12H9ClN4O, CAS 1187336-15-7
3-(2-Chlorophenyl)-5-(3-methyl-1H-pyrazol-5-yl)-1,2,4-oxadiazole
CAS 1187336-15-7C12H9ClN4O
3-(3-Chlorophenyl)-5-(3-methyl-1H-pyrazol-5-yl)-1,2,4-oxadiazole chemical structure, C12H9ClN4O, CAS 1192557-03-1
3-(3-Chlorophenyl)-5-(3-methyl-1H-pyrazol-5-yl)-1,2,4-oxadiazole
CAS 1192557-03-1C12H9ClN4O
3-(3,4-Dimethoxyphenyl)-5-(3-methyl-1H-pyrazol-5-yl)-1,2,4-oxadiazole chemical structure, C14H14N4O3, CAS 1192487-61-8
3-(3,4-Dimethoxyphenyl)-5-(3-methyl-1H-pyrazol-5-yl)-1,2,4-oxadiazole
CAS 1192487-61-8C14H14N4O3
5-(1-Ethyl-4-nitro-1H-pyrazol-3-yl)-3-(4-fluorophenyl)-1,2,4-oxadiazole chemical structure, C13H10FN5O3, CAS 1005617-40-2
5-(1-Ethyl-4-nitro-1H-pyrazol-3-yl)-3-(4-fluorophenyl)-1,2,4-oxadiazole
CAS 1005617-40-2C13H10FN5O3
5-[1-(Difluoromethyl)-1H-pyrazol-5-yl]-3-phenyl-1,2,4-oxadiazole chemical structure, C12H8F2N4O, CAS 1005684-53-6
5-[1-(Difluoromethyl)-1H-pyrazol-5-yl]-3-phenyl-1,2,4-oxadiazole
CAS 1005684-53-6C12H8F2N4O
3-(4-Methylphenyl)-5-[3-(propan-2-yl)-1H-pyrazol-5-yl]-1,2,4-oxadiazole chemical structure, C15H16N4O, CAS 1094606-19-5
3-(4-Methylphenyl)-5-[3-(propan-2-yl)-1H-pyrazol-5-yl]-1,2,4-oxadiazole
CAS 1094606-19-5C15H16N4O
3-(3,4-Dimethoxyphenyl)-5-(3-isopropyl-1H-pyrazol-5-yl)-1,2,4-oxadiazole chemical structure, C16H18N4O3, CAS 1192572-12-5
3-(3,4-Dimethoxyphenyl)-5-(3-isopropyl-1H-pyrazol-5-yl)-1,2,4-oxadiazole
CAS 1192572-12-5C16H18N4O3
1-{3-[5-(1-Methyl-1H-pyrazol-5-yl)-1,2,4-oxadiazol-3-yl]phenyl}-3-(propan-2-yl)urea chemical structure, C16H18N6O2, CAS 1189450-22-3
1-{3-[5-(1-Methyl-1H-pyrazol-5-yl)-1,2,4-oxadiazol-3-yl]phenyl}-3-(propan-2-yl)urea
CAS 1189450-22-3C16H18N6O2
5-(5-Methyl-1H-pyrazol-3-yl)-3-[4-(trimethylsilyl)phenyl]-1,2,4-oxadiazole chemical structure, C15H18N4OSi, CAS 1225380-26-6
5-(5-Methyl-1H-pyrazol-3-yl)-3-[4-(trimethylsilyl)phenyl]-1,2,4-oxadiazole
CAS 1225380-26-6C15H18N4OSi