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Murcko scaffold

Ring system with 2 rings and 15 atoms

36 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
36
With full pages
7
Scaffold SMILES

O=C(C=Cc1cn[nH]c1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1cn[nH]c1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 36 of 36 chemicals

3-[5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-1-(4-methylphenyl)-2-propen-1-one chemical structure, C15H12ClF3N2O, CAS 648859-49-8
3-[5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-1-(4-methylphenyl)-2-propen-1-one
CAS 648859-49-8C15H12ClF3N2O
1-[3-(Difluoromethoxy)phenyl]-3-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2-propen-1-one chemical structure, C16H16F2N2O2, CAS 1005696-52-5
1-[3-(Difluoromethoxy)phenyl]-3-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2-propen-1-one
CAS 1005696-52-5C16H16F2N2O2
3-(1-Methyl-1H-pyrazol-4-yl)-2-nitro-1-phenyl-2-propen-1-one chemical structure, C13H11N3O3, CAS 1005632-52-9
3-(1-Methyl-1H-pyrazol-4-yl)-2-nitro-1-phenyl-2-propen-1-one
CAS 1005632-52-9C13H11N3O3
(E)-3-[5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-1-(3,4-dichlorophenyl)-2-propen-1-one chemical structure, C14H8Cl3F3N2O, CAS 956376-47-9
(E)-3-[5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-1-(3,4-dichlorophenyl)-2-propen-1-one
CAS 956376-47-9C14H8Cl3F3N2O
3-[5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-1-(4-chlorophenyl)prop-2-en-1-one chemical structure, C14H9Cl2F3N2O, CAS 648859-48-7
3-[5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-1-(4-chlorophenyl)prop-2-en-1-one
CAS 648859-48-7C14H9Cl2F3N2O
3-[5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-1-(4-methylphenyl)prop-2-en-1-one chemical structure, C15H12ClF3N2O, CAS 1980010-86-3
3-[5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-1-(4-methylphenyl)prop-2-en-1-one
CAS 1980010-86-3C15H12ClF3N2O
(E)-3-(1,5-Dimethylpyrazol-4-yl)-1-(4-hydroxyphenyl)prop-2-en-1-one chemical structure, C14H14N2O2, CAS 1164453-36-4
(E)-3-(1,5-Dimethylpyrazol-4-yl)-1-(4-hydroxyphenyl)prop-2-en-1-one
CAS 1164453-36-4C14H14N2O2
(E)-3-(1-Ethyl-3-methylpyrazol-4-yl)-1-(4-hydroxyphenyl)prop-2-en-1-one chemical structure, C15H16N2O2, CAS 700350-03-4
(E)-3-(1-Ethyl-3-methylpyrazol-4-yl)-1-(4-hydroxyphenyl)prop-2-en-1-one
CAS 700350-03-4C15H16N2O2
(E)-3-(1-Ethyl-5-methyl-1H-pyrazol-4-yl)-1-(4-fluorophenyl)prop-2-en-1-one chemical structure, C15H15FN2O, CAS 494219-32-8
(E)-3-(1-Ethyl-5-methyl-1H-pyrazol-4-yl)-1-(4-fluorophenyl)prop-2-en-1-one
CAS 494219-32-8C15H15FN2O
3-(1,3-Dimethyl-1H-pyrazol-4-yl)-1-phenyl-2-propen-1-one chemical structure, C14H14N2O, CAS 1164505-27-4
3-(1,3-Dimethyl-1H-pyrazol-4-yl)-1-phenyl-2-propen-1-one
CAS 1164505-27-4C14H14N2O
(E)-1-(4-Iodophenyl)-3-(1,3,5-trimethylpyrazol-4-yl)prop-2-en-1-one chemical structure, C15H15IN2O, CAS 494791-29-6
(E)-1-(4-Iodophenyl)-3-(1,3,5-trimethylpyrazol-4-yl)prop-2-en-1-one
CAS 494791-29-6C15H15IN2O
3-(1,5-Dimethyl-1H-pyrazol-4-yl)-1-phenyl-2-propen-1-one chemical structure, C14H14N2O, CAS 1164493-09-7
3-(1,5-Dimethyl-1H-pyrazol-4-yl)-1-phenyl-2-propen-1-one
CAS 1164493-09-7C14H14N2O
3-(1-Ethyl-5-methyl-1H-pyrazol-4-yl)-1-phenyl-2-propen-1-one chemical structure, C15H16N2O, CAS 1164513-59-0
3-(1-Ethyl-5-methyl-1H-pyrazol-4-yl)-1-phenyl-2-propen-1-one
CAS 1164513-59-0C15H16N2O
3-(1-Ethyl-3,5-dimethyl-1H-pyrazol-4-yl)-1-(4-iodophenyl)-2-propen-1-one chemical structure, C16H17IN2O, CAS 494791-24-1
3-(1-Ethyl-3,5-dimethyl-1H-pyrazol-4-yl)-1-(4-iodophenyl)-2-propen-1-one
CAS 494791-24-1C16H17IN2O
(E)-3-(1-Ethyl-5-methyl-1H-pyrazol-4-yl)-1-(4-iodophenyl)prop-2-en-1-one chemical structure, C15H15IN2O, CAS 494219-59-9
(E)-3-(1-Ethyl-5-methyl-1H-pyrazol-4-yl)-1-(4-iodophenyl)prop-2-en-1-one
CAS 494219-59-9C15H15IN2O
(E)-3-(1,5-Dimethylpyrazol-4-yl)-1-(4-propan-2-ylphenyl)prop-2-en-1-one chemical structure, C17H20N2O, CAS 512814-31-2
(E)-3-(1,5-Dimethylpyrazol-4-yl)-1-(4-propan-2-ylphenyl)prop-2-en-1-one
CAS 512814-31-2C17H20N2O
(E)-3-(1,5-Dimethylpyrazol-4-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one chemical structure, C14H14N2O2, CAS 1164454-89-0
(E)-3-(1,5-Dimethylpyrazol-4-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one
CAS 1164454-89-0C14H14N2O2
(2E)-3-(1,3-Dimethyl-1H-pyrazol-4-yl)-1-(4-fluorophenyl)prop-2-en-1-one chemical structure, C14H13FN2O, CAS 959003-61-3
(2E)-3-(1,3-Dimethyl-1H-pyrazol-4-yl)-1-(4-fluorophenyl)prop-2-en-1-one
CAS 959003-61-3C14H13FN2O
(E)-3-(1,3-Dimethyl-1H-pyrazol-4-yl)-1-(3-hydroxyphenyl)prop-2-en-1-one chemical structure, C14H14N2O2, CAS 1005576-49-7
(E)-3-(1,3-Dimethyl-1H-pyrazol-4-yl)-1-(3-hydroxyphenyl)prop-2-en-1-one
CAS 1005576-49-7C14H14N2O2
(E)-3-(1,3-Dimethylpyrazol-4-yl)-1-(3-methoxyphenyl)prop-2-en-1-one chemical structure, C15H16N2O2, CAS 1005556-00-2
(E)-3-(1,3-Dimethylpyrazol-4-yl)-1-(3-methoxyphenyl)prop-2-en-1-one
CAS 1005556-00-2C15H16N2O2
Propenone, 3-(1-methyl-1H-pyrazol-4-yl)-1-phenyl- chemical structure, C13H12N2O, CAS 959003-66-8
Propenone, 3-(1-methyl-1H-pyrazol-4-yl)-1-phenyl-
CAS 959003-66-8C13H12N2O
(2E)-3-(1,3-Dimethyl-1H-pyrazol-4-yl)-1-(4-methoxyphenyl)prop-2-en-1-one chemical structure, C15H16N2O2, CAS 49593-47-7
(2E)-3-(1,3-Dimethyl-1H-pyrazol-4-yl)-1-(4-methoxyphenyl)prop-2-en-1-one
CAS 49593-47-7C15H16N2O2
(2E)-1-[3-(Difluoromethoxy)phenyl]-3-(1,5-dimethyl-1H-pyrazol-4-yl)prop-2-en-1-one chemical structure, C15H14F2N2O2, CAS 1005647-45-9
(2E)-1-[3-(Difluoromethoxy)phenyl]-3-(1,5-dimethyl-1H-pyrazol-4-yl)prop-2-en-1-one
CAS 1005647-45-9C15H14F2N2O2
(2E)-3-(1,5-Dimethyl-1H-pyrazol-4-yl)-1-(3-methoxyphenyl)prop-2-en-1-one chemical structure, C15H16N2O2, CAS 1005648-53-2
(2E)-3-(1,5-Dimethyl-1H-pyrazol-4-yl)-1-(3-methoxyphenyl)prop-2-en-1-one
CAS 1005648-53-2C15H16N2O2