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Murcko scaffold

Ring system with 2 rings and 15 atoms

75 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
75
With full pages
10
Scaffold SMILES

O=C(C=Cc1ccccc1)N1CCCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1)N1CCCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 75 chemicals

1-Pyrrolidin-1-yl-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one chemical structure, C16H21NO4
1-Pyrrolidin-1-yl-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
C16H21NO4
3-(3-Methoxyphenyl)-1-(pyrrolidin-1-yl)prop-2-en-1-one chemical structure, C14H17NO2, CAS 29647-01-6
3-(3-Methoxyphenyl)-1-(pyrrolidin-1-yl)prop-2-en-1-one
CAS 29647-01-6C14H17NO2
alpha-[(3,4-Dimethoxyphenyl)methylene]-beta-oxo-1-pyrrolidinepropanenitrile chemical structure, C16H18N2O3, CAS 457093-81-1
alpha-[(3,4-Dimethoxyphenyl)methylene]-beta-oxo-1-pyrrolidinepropanenitrile
CAS 457093-81-1C16H18N2O3
(2E)-3-[4-(2-Methylpropyl)phenyl]-1-pyrrolidinylprop-2-en-1-one chemical structure, C17H23NO, CAS 329059-03-2
(2E)-3-[4-(2-Methylpropyl)phenyl]-1-pyrrolidinylprop-2-en-1-one
CAS 329059-03-2C17H23NO
1-[(2E)-3-(4-Nitrophenyl)prop-2-enoyl]pyrrolidine chemical structure, C13H14N2O3, CAS 112601-98-6
1-[(2E)-3-(4-Nitrophenyl)prop-2-enoyl]pyrrolidine
CAS 112601-98-6C13H14N2O3
(E)-3-Phenyl-1-(pyrrolidino)-2-propen-1-one chemical structure, C13H15NO, CAS 52438-21-8
(E)-3-Phenyl-1-(pyrrolidino)-2-propen-1-one
CAS 52438-21-8C13H15NO
Piperlotine A chemical structure, C14H17NO2, CAS 389572-70-7
Piperlotine A
CAS 389572-70-7C14H17NO2
1-(3,4,5-Trimethoxycinnamoyl)pyrrolidine chemical structure, C16H21NO4, CAS 1703-35-1
1-(3,4,5-Trimethoxycinnamoyl)pyrrolidine
CAS 1703-35-1C16H21NO4
Pyrrolidine, 1-[3-(4-chlorophenyl)-1-oxo-2-propenyl]- chemical structure, C13H14ClNO, CAS 19199-32-7
Pyrrolidine, 1-[3-(4-chlorophenyl)-1-oxo-2-propenyl]-
CAS 19199-32-7C13H14ClNO
1-[3-(4-Chlorophenyl)acryloyl]pyrrolidine chemical structure, C13H14ClNO, CAS 389572-71-8
1-[3-(4-Chlorophenyl)acryloyl]pyrrolidine
CAS 389572-71-8C13H14ClNO
3-(4-Ethylphenyl)-1-(pyrrolidin-1-yl)prop-2-en-1-one chemical structure, C15H19NO, CAS 514841-53-3
3-(4-Ethylphenyl)-1-(pyrrolidin-1-yl)prop-2-en-1-one
CAS 514841-53-3C15H19NO
1-[3-(2,6-Dichlorophenyl)acryloyl]pyrrolidine chemical structure, C13H13Cl2NO, CAS 560104-54-3
1-[3-(2,6-Dichlorophenyl)acryloyl]pyrrolidine
CAS 560104-54-3C13H13Cl2NO
(E)-3-(2-Nitrophenyl)-1-pyrrolidin-1-ylprop-2-en-1-one chemical structure, C13H14N2O3, CAS 1801910-47-3
(E)-3-(2-Nitrophenyl)-1-pyrrolidin-1-ylprop-2-en-1-one
CAS 1801910-47-3C13H14N2O3
(E)-3-(3,4-Dichlorophenyl)-1-pyrrolidin-1-ylprop-2-en-1-one chemical structure, C13H13Cl2NO, CAS 42174-45-8
(E)-3-(3,4-Dichlorophenyl)-1-pyrrolidin-1-ylprop-2-en-1-one
CAS 42174-45-8C13H13Cl2NO
(Z)-2-Chloro-3-phenyl-1-(pyrrolidin-1-yl)prop-2-en-1-one chemical structure, C13H14ClNO, CAS 292153-68-5
(Z)-2-Chloro-3-phenyl-1-(pyrrolidin-1-yl)prop-2-en-1-one
CAS 292153-68-5C13H14ClNO
(E)-3-(3,4-Dihydroxyphenyl)-2-(pyrrolidine-1-carbonyl)prop-2-enenitrile chemical structure, C14H14N2O3, CAS 454201-12-8
(E)-3-(3,4-Dihydroxyphenyl)-2-(pyrrolidine-1-carbonyl)prop-2-enenitrile
CAS 454201-12-8C14H14N2O3
(E)-3-(4-Hydroxyphenyl)-2-(pyrrolidine-1-carbonyl)prop-2-enenitrile chemical structure, C14H14N2O2, CAS 454212-32-9
(E)-3-(4-Hydroxyphenyl)-2-(pyrrolidine-1-carbonyl)prop-2-enenitrile
CAS 454212-32-9C14H14N2O2
Methyl 4-[2-cyano-2-(pyrrolidine-1-carbonyl)eth-1-en-1-yl]benzoate chemical structure, C16H16N2O3, CAS 455312-50-2
Methyl 4-[2-cyano-2-(pyrrolidine-1-carbonyl)eth-1-en-1-yl]benzoate
CAS 455312-50-2C16H16N2O3
4-[2-Cyano-2-(pyrrolidine-1-carbonyl)eth-1-en-1-yl]benzonitrile chemical structure, C15H13N3O, CAS 452951-87-0
4-[2-Cyano-2-(pyrrolidine-1-carbonyl)eth-1-en-1-yl]benzonitrile
CAS 452951-87-0C15H13N3O
Piperlotine D chemical structure, C16H21NO4, CAS 958296-13-4
Piperlotine D
CAS 958296-13-4C16H21NO4
1-[(2E)-3-(3-Nitrophenyl)prop-2-enoyl]pyrrolidine chemical structure, C13H14N2O3, CAS 1426293-57-3
1-[(2E)-3-(3-Nitrophenyl)prop-2-enoyl]pyrrolidine
CAS 1426293-57-3C13H14N2O3
3-[4-(Difluoromethoxy)phenyl]-2-(pyrrolidine-1-carbonyl)prop-2-enenitrile chemical structure, C15H14F2N2O2, CAS 327089-25-8
3-[4-(Difluoromethoxy)phenyl]-2-(pyrrolidine-1-carbonyl)prop-2-enenitrile
CAS 327089-25-8C15H14F2N2O2
N-{4-[2-Cyano-2-(pyrrolidine-1-carbonyl)eth-1-en-1-yl]phenyl}acetamide chemical structure, C16H17N3O2, CAS 736959-29-8
N-{4-[2-Cyano-2-(pyrrolidine-1-carbonyl)eth-1-en-1-yl]phenyl}acetamide
CAS 736959-29-8C16H17N3O2
3-(2-Bromophenyl)-2-(pyrrolidine-1-carbonyl)prop-2-enenitrile chemical structure, C14H13BrN2O, CAS 455299-61-3
3-(2-Bromophenyl)-2-(pyrrolidine-1-carbonyl)prop-2-enenitrile
CAS 455299-61-3C14H13BrN2O