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Murcko scaffold

Ring system with 2 rings and 15 atoms

75 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
75
With full pages
10
Scaffold SMILES

O=C(C=Cc1ccccc1)N1CCCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1)N1CCCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 75 of 75 chemicals

1-[3-(4-Carbamoylphenyl)prop-2-enoyl]pyrrolidine-2-carboxylic acid chemical structure, C15H16N2O4, CAS 1485808-95-4
1-[3-(4-Carbamoylphenyl)prop-2-enoyl]pyrrolidine-2-carboxylic acid
CAS 1485808-95-4C15H16N2O4
1-[(2E)-3-(4-Hydroxy-3-methoxyphenyl)prop-2-enoyl]proline chemical structure, C15H17NO5, CAS 2640121-22-6
1-[(2E)-3-(4-Hydroxy-3-methoxyphenyl)prop-2-enoyl]proline
CAS 2640121-22-6C15H17NO5
1-(3-(2-Chloro-3-methoxyphenyl)-2-propenoyl)pyrrolidine chemical structure, C14H16ClNO2, CAS 853351-00-5
1-(3-(2-Chloro-3-methoxyphenyl)-2-propenoyl)pyrrolidine
CAS 853351-00-5C14H16ClNO2
(2Z)-3-(4-Hydroxy-3,5-dimethylphenyl)-2-[(Z)-pyrrolidine-1-carbonyl]prop-2-enenitrile chemical structure, C16H18N2O2, CAS 1281682-35-6
(2Z)-3-(4-Hydroxy-3,5-dimethylphenyl)-2-[(Z)-pyrrolidine-1-carbonyl]prop-2-enenitrile
CAS 1281682-35-6C16H18N2O2
N-Cinnamoyl-L-proline chemical structure, C14H15NO3, CAS 76084-32-7
N-Cinnamoyl-L-proline
CAS 76084-32-7C14H15NO3
(2E)-3-(4-Hydroxyphenyl)-1-(1-pyrrolidinyl)-2-propen-1-one chemical structure, C13H15NO2, CAS 958296-14-5
(2E)-3-(4-Hydroxyphenyl)-1-(1-pyrrolidinyl)-2-propen-1-one
CAS 958296-14-5C13H15NO2
1-(3-Aminopyrrolidin-1-yl)-3-phenylprop-2-en-1-one chemical structure, C13H16N2O, CAS 1251449-37-2
1-(3-Aminopyrrolidin-1-yl)-3-phenylprop-2-en-1-one
CAS 1251449-37-2C13H16N2O
(E)-1-(3-Aminopyrrolidin-1-yl)-3-(4-fluorophenyl)prop-2-en-1-one chemical structure, C13H15FN2O, CAS 1286376-86-0
(E)-1-(3-Aminopyrrolidin-1-yl)-3-(4-fluorophenyl)prop-2-en-1-one
CAS 1286376-86-0C13H15FN2O
(E)-1-(3-Hydroxypyrrolidin-1-yl)-3-(o-tolyl)prop-2-en-1-one chemical structure, C14H17NO2, CAS 1563117-65-6
(E)-1-(3-Hydroxypyrrolidin-1-yl)-3-(o-tolyl)prop-2-en-1-one
CAS 1563117-65-6C14H17NO2
(2E)-3-(4-Fluorophenyl)-1-(3-hydroxypyrrolidin-1-yl)prop-2-en-1-one chemical structure, C13H14FNO2, CAS 1286233-58-6
(2E)-3-(4-Fluorophenyl)-1-(3-hydroxypyrrolidin-1-yl)prop-2-en-1-one
CAS 1286233-58-6C13H14FNO2
1-Cinnamoyl-3-hydroxypyrrolidine chemical structure, C13H15NO2, CAS 1344876-77-2
1-Cinnamoyl-3-hydroxypyrrolidine
CAS 1344876-77-2C13H15NO2
(E)-3-(2-Fluorophenyl)-1-(3-hydroxypyrrolidin-1-yl)prop-2-en-1-one chemical structure, C13H14FNO2, CAS 1562838-37-2
(E)-3-(2-Fluorophenyl)-1-(3-hydroxypyrrolidin-1-yl)prop-2-en-1-one
CAS 1562838-37-2C13H14FNO2
1-(2-Methyl-3-phenylacryloyl)-L-proline chemical structure, C15H17NO3, CAS 63742-09-6
1-(2-Methyl-3-phenylacryloyl)-L-proline
CAS 63742-09-6C15H17NO3
1-[(2S)-2-(2-Oxopropyl)pyrrolidin-1-yl]-3-phenylprop-2-en-1-one chemical structure, C16H19NO2, CAS 851439-76-4
1-[(2S)-2-(2-Oxopropyl)pyrrolidin-1-yl]-3-phenylprop-2-en-1-one
CAS 851439-76-4C16H19NO2
1-(2-Methoxypyrrolidin-1-yl)-3-phenylprop-2-en-1-one chemical structure, C14H17NO2, CAS 922149-10-8
1-(2-Methoxypyrrolidin-1-yl)-3-phenylprop-2-en-1-one
CAS 922149-10-8C14H17NO2
3-(4-Methoxyphenyl)-1-(pyrrolidin-1-yl)but-2-en-1-one chemical structure, C15H19NO2, CAS 90316-42-0
3-(4-Methoxyphenyl)-1-(pyrrolidin-1-yl)but-2-en-1-one
CAS 90316-42-0C15H19NO2
(E)-1-(3-(Methylsulfonyl)pyrrolidin-1-yl)-3-phenylprop-2-en-1-one chemical structure, C14H17NO3S, CAS 1448140-49-5
(E)-1-(3-(Methylsulfonyl)pyrrolidin-1-yl)-3-phenylprop-2-en-1-one
CAS 1448140-49-5C14H17NO3S
(E)-3-(2-Chlorophenyl)-1-(3-(methylsulfonyl)pyrrolidin-1-yl)prop-2-en-1-one chemical structure, C14H16ClNO3S, CAS 1448139-79-4
(E)-3-(2-Chlorophenyl)-1-(3-(methylsulfonyl)pyrrolidin-1-yl)prop-2-en-1-one
CAS 1448139-79-4C14H16ClNO3S
(E)-1-(3-(Methylthio)pyrrolidin-1-yl)-3-phenylprop-2-en-1-one chemical structure, C14H17NOS, CAS 1798397-36-0
(E)-1-(3-(Methylthio)pyrrolidin-1-yl)-3-phenylprop-2-en-1-one
CAS 1798397-36-0C14H17NOS
(E)-1-(3-(Methylthio)pyrrolidin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one chemical structure, C17H23NO4S, CAS 1798419-67-6
(E)-1-(3-(Methylthio)pyrrolidin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
CAS 1798419-67-6C17H23NO4S
(E)-Methyl 2-((1-cinnamoylpyrrolidin-3-yl)thio)acetate chemical structure, C16H19NO3S, CAS 2035021-88-4
(E)-Methyl 2-((1-cinnamoylpyrrolidin-3-yl)thio)acetate
CAS 2035021-88-4C16H19NO3S
(E)-Methyl 2-((1-(3-(2-chlorophenyl)acryloyl)pyrrolidin-3-yl)thio)acetate chemical structure, C16H18ClNO3S, CAS 2035021-90-8
(E)-Methyl 2-((1-(3-(2-chlorophenyl)acryloyl)pyrrolidin-3-yl)thio)acetate
CAS 2035021-90-8C16H18ClNO3S
(2Z)-1-(3-Aminopyrrolidin-1-yl)-2-methyl-3-phenylprop-2-en-1-one chemical structure, C14H18N2O, CAS 1564082-14-9
(2Z)-1-(3-Aminopyrrolidin-1-yl)-2-methyl-3-phenylprop-2-en-1-one
CAS 1564082-14-9C14H18N2O
(2E)-1-(3-Aminopyrrolidin-1-yl)-3-(2-methylphenyl)prop-2-en-1-one chemical structure, C14H18N2O, CAS 1564082-35-4
(2E)-1-(3-Aminopyrrolidin-1-yl)-3-(2-methylphenyl)prop-2-en-1-one
CAS 1564082-35-4C14H18N2O