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Murcko scaffold

Ring system with 3 rings and 20 atoms

5 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
5
With full pages
0
Scaffold SMILES

O=C(C=Cc1ccccc1)Nc1cc2c(s1)COCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1)Nc1cc2c(s1)COCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 5 of 5 chemicals

Ethyl 2-(cinnamoylamino)-5,5-dimethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylate chemical structure, C21H23NO4S, CAS 327167-10-2
Ethyl 2-(cinnamoylamino)-5,5-dimethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylate
CAS 327167-10-2C21H23NO4S
Ethyl 2-[[3-(4-fluorophenyl)-1-oxo-2-propen-1-yl]amino]-4,7-dihydro-5,5-dimethyl-5H-thieno[2,3-c]pyran-3-carboxylate chemical structure, C21H22FNO4S, CAS 381679-25-0
Ethyl 2-[[3-(4-fluorophenyl)-1-oxo-2-propen-1-yl]amino]-4,7-dihydro-5,5-dimethyl-5H-thieno[2,3-c]pyran-3-carboxylate
CAS 381679-25-0C21H22FNO4S
AC1Lrddz chemical structure, C23H27NO6S, CAS 6065-78-7
AC1Lrddz
CAS 6065-78-7C23H27NO6S
(E)-N-(3-Cyano-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-2-yl)-3-(3,4-dimethoxyphenyl)prop-2-enamide chemical structure, C21H22N2O4S, CAS 371200-99-6
(E)-N-(3-Cyano-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-2-yl)-3-(3,4-dimethoxyphenyl)prop-2-enamide
CAS 371200-99-6C21H22N2O4S
Ethyl 2-{[(2E)-3-(4-methoxyphenyl)prop-2-enoyl]amino}-5,5-dimethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylate chemical structure, C22H25NO5S, CAS 371202-13-0
Ethyl 2-{[(2E)-3-(4-methoxyphenyl)prop-2-enoyl]amino}-5,5-dimethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylate
CAS 371202-13-0C22H25NO5S