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Murcko scaffold

4-Benzyl-N-phenylpiperazine-1-carboxamide scaffold

81 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
81
With full pages
7
Scaffold SMILES

O=C(Nc1ccccc1)N1CCN(Cc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-Benzyl-N-phenylpiperazine-1-carboxamide page
Murcko scaffold O=C(Nc1ccccc1)N1CCN(Cc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 81 chemicals

4-Benzyl-N-phenylpiperazine-1-carboxamide chemical structure, C18H21N3O, CAS 65766-74-7
4-Benzyl-N-phenylpiperazine-1-carboxamide
CAS 65766-74-7C18H21N3O
4-Benzyl-N-(4-fluorophenyl)piperazine-1-carboxamide chemical structure, C18H20FN3O, CAS 553657-54-8
4-Benzyl-N-(4-fluorophenyl)piperazine-1-carboxamide
CAS 553657-54-8C18H20FN3O
4-Benzyl-N-(3-chlorophenyl)-1-piperazinecarboxamide chemical structure, C18H20ClN3O, CAS 397863-68-2
4-Benzyl-N-(3-chlorophenyl)-1-piperazinecarboxamide
CAS 397863-68-2C18H20ClN3O
N-(2,4-Difluorophenyl)-4-[(3-fluorophenyl)methyl]piperazine-1-carboxamide chemical structure, C18H18F3N3O, CAS 708224-47-9
N-(2,4-Difluorophenyl)-4-[(3-fluorophenyl)methyl]piperazine-1-carboxamide
CAS 708224-47-9C18H18F3N3O
4-Benzyl-N-(2-chloro-4,5-difluorophenyl)piperazine-1-carboxamide chemical structure, C18H18ClF2N3O, CAS 331710-62-4
4-Benzyl-N-(2-chloro-4,5-difluorophenyl)piperazine-1-carboxamide
CAS 331710-62-4C18H18ClF2N3O
N-(2,4-Difluorophenyl)-4-[(3-methoxyphenyl)methyl]piperazine-1-carboxamide chemical structure, C19H21F2N3O2, CAS 701938-57-0
N-(2,4-Difluorophenyl)-4-[(3-methoxyphenyl)methyl]piperazine-1-carboxamide
CAS 701938-57-0C19H21F2N3O2
Ethyl 4-({4-[(2,4-dichlorophenyl)methyl]piperazinyl}carbonylamino)benzoate chemical structure, C21H23Cl2N3O3, CAS 701952-62-7
Ethyl 4-({4-[(2,4-dichlorophenyl)methyl]piperazinyl}carbonylamino)benzoate
CAS 701952-62-7C21H23Cl2N3O3
4-[(3,4-Dichlorophenyl)methyl]-N-[2-(trifluoromethyl)phenyl]piperazine-1-carboxamide chemical structure, C19H18Cl2F3N3O, CAS 708248-67-3
4-[(3,4-Dichlorophenyl)methyl]-N-[2-(trifluoromethyl)phenyl]piperazine-1-carboxamide
CAS 708248-67-3C19H18Cl2F3N3O
N-(4-Ethoxyphenyl)-4-[(4-fluorophenyl)methyl]piperazine-1-carboxamide chemical structure, C20H24FN3O2, CAS 824420-98-6
N-(4-Ethoxyphenyl)-4-[(4-fluorophenyl)methyl]piperazine-1-carboxamide
CAS 824420-98-6C20H24FN3O2
4-[(3,4-Dichlorophenyl)methyl]-N-(2-ethoxyphenyl)piperazine-1-carboxamide chemical structure, C20H23Cl2N3O2, CAS 824422-21-1
4-[(3,4-Dichlorophenyl)methyl]-N-(2-ethoxyphenyl)piperazine-1-carboxamide
CAS 824422-21-1C20H23Cl2N3O2
4-[(2-Methylphenyl)methyl]-N-(3-nitrophenyl)piperazine-1-carboxamide chemical structure, C19H22N4O3, CAS 824422-78-8
4-[(2-Methylphenyl)methyl]-N-(3-nitrophenyl)piperazine-1-carboxamide
CAS 824422-78-8C19H22N4O3
4-[(3,4-Dichlorophenyl)methyl]-N-(2,4-difluorophenyl)piperazine-1-carboxamide chemical structure, C18H17Cl2F2N3O, CAS 824941-33-5
4-[(3,4-Dichlorophenyl)methyl]-N-(2,4-difluorophenyl)piperazine-1-carboxamide
CAS 824941-33-5C18H17Cl2F2N3O
4-[(3-Methoxyphenyl)methyl]-N-(4-nitrophenyl)piperazine-1-carboxamide chemical structure, C19H22N4O4, CAS 439849-15-7
4-[(3-Methoxyphenyl)methyl]-N-(4-nitrophenyl)piperazine-1-carboxamide
CAS 439849-15-7C19H22N4O4
4-Benzyl-N-(2-ethylphenyl)piperazine-1-carboxamide chemical structure, C20H25N3O, CAS 890570-79-3
4-Benzyl-N-(2-ethylphenyl)piperazine-1-carboxamide
CAS 890570-79-3C20H25N3O
Ethyl 4-{[(4-benzyl-1-piperazinyl)carbonyl]amino}benzoate chemical structure, C21H25N3O3, CAS 168893-18-3
Ethyl 4-{[(4-benzyl-1-piperazinyl)carbonyl]amino}benzoate
CAS 168893-18-3C21H25N3O3
4-Benzyl-N-(3-chloro-4-methylphenyl)-1-piperazinecarboxamide chemical structure, C19H22ClN3O, CAS 853319-21-8
4-Benzyl-N-(3-chloro-4-methylphenyl)-1-piperazinecarboxamide
CAS 853319-21-8C19H22ClN3O
4-Benzyl-N-(2-methylphenyl)piperazine-1-carboxamide chemical structure, C19H23N3O, CAS 896564-24-2
4-Benzyl-N-(2-methylphenyl)piperazine-1-carboxamide
CAS 896564-24-2C19H23N3O
4-Benzyl-N-(5-chloro-2-methylphenyl)piperazine-1-carboxamide chemical structure, C19H22ClN3O, CAS 904848-68-6
4-Benzyl-N-(5-chloro-2-methylphenyl)piperazine-1-carboxamide
CAS 904848-68-6C19H22ClN3O
N-(2,3-Dimethylphenyl)-4-[(3-fluorophenyl)methyl]piperazine-1-carboxamide chemical structure, C20H24FN3O, CAS 894158-82-8
N-(2,3-Dimethylphenyl)-4-[(3-fluorophenyl)methyl]piperazine-1-carboxamide
CAS 894158-82-8C20H24FN3O
N-(3,4-Dimethoxyphenyl)-4-[(2-methylphenyl)methyl]piperazine-1-carboxamide chemical structure, C21H27N3O3, CAS 892805-95-7
N-(3,4-Dimethoxyphenyl)-4-[(2-methylphenyl)methyl]piperazine-1-carboxamide
CAS 892805-95-7C21H27N3O3
N-(3,4-Dimethylphenyl)-4-[(4-fluorophenyl)methyl]piperazine-1-carboxamide chemical structure, C20H24FN3O, CAS 894210-59-4
N-(3,4-Dimethylphenyl)-4-[(4-fluorophenyl)methyl]piperazine-1-carboxamide
CAS 894210-59-4C20H24FN3O
4-[(2-Chlorophenyl)methyl]-N-(4-methoxyphenyl)piperazine-1-carboxamide chemical structure, C19H22ClN3O2, CAS 893172-20-8
4-[(2-Chlorophenyl)methyl]-N-(4-methoxyphenyl)piperazine-1-carboxamide
CAS 893172-20-8C19H22ClN3O2
4-[(4-Fluorophenyl)methyl]-N-phenylpiperazine-1-carboxamide chemical structure, C18H20FN3O, CAS 896573-78-7
4-[(4-Fluorophenyl)methyl]-N-phenylpiperazine-1-carboxamide
CAS 896573-78-7C18H20FN3O
4-[(4-Fluorophenyl)methyl]-N-(2-methoxy-5-methylphenyl)piperazine-1-carboxamide chemical structure, C20H24FN3O2, CAS 892829-24-2
4-[(4-Fluorophenyl)methyl]-N-(2-methoxy-5-methylphenyl)piperazine-1-carboxamide
CAS 892829-24-2C20H24FN3O2