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Murcko scaffold

Ring system with 2 rings and 20 atoms

253 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
20
Chemicals
253
With full pages
18
Scaffold SMILES

O=C(C=Cc1ccccc1)NC(=S)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1)NC(=S)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 253 chemicals

(E)-3-(4-Fluorophenyl)-N-[(2-hydroxyphenyl)carbamothioyl]prop-2-enamide chemical structure, C16H13FN2O2S, CAS 328271-07-4
(E)-3-(4-Fluorophenyl)-N-[(2-hydroxyphenyl)carbamothioyl]prop-2-enamide
CAS 328271-07-4C16H13FN2O2S
(E)-N-[(2-Hydroxyphenyl)carbamothioyl]-3-phenylprop-2-enamide chemical structure, C16H14N2O2S, CAS 123533-70-0
(E)-N-[(2-Hydroxyphenyl)carbamothioyl]-3-phenylprop-2-enamide
CAS 123533-70-0C16H14N2O2S
(E)-N-[(4-Acetylphenyl)carbamothioyl]-3-phenylprop-2-enamide chemical structure, C18H16N2O2S, CAS 412963-67-8
(E)-N-[(4-Acetylphenyl)carbamothioyl]-3-phenylprop-2-enamide
CAS 412963-67-8C18H16N2O2S
(E)-3-(4-Fluorophenyl)-N-(phenylcarbamothioyl)prop-2-enamide chemical structure, C16H13FN2OS, CAS 412963-90-7
(E)-3-(4-Fluorophenyl)-N-(phenylcarbamothioyl)prop-2-enamide
CAS 412963-90-7C16H13FN2OS
(E)-N-[(2-Chlorophenyl)carbamothioyl]-3-(4-fluorophenyl)prop-2-enamide chemical structure, C16H12ClFN2OS, CAS 412963-94-1
(E)-N-[(2-Chlorophenyl)carbamothioyl]-3-(4-fluorophenyl)prop-2-enamide
CAS 412963-94-1C16H12ClFN2OS
(E)-3-(3,4-Dimethoxyphenyl)-N-(phenylcarbamothioyl)prop-2-enamide chemical structure, C18H18N2O3S, CAS 412964-00-2
(E)-3-(3,4-Dimethoxyphenyl)-N-(phenylcarbamothioyl)prop-2-enamide
CAS 412964-00-2C18H18N2O3S
4-Methyl-3-({[(2E)-3-phenylprop-2-enoyl]carbamothioyl}amino)benzoic acid chemical structure, C18H16N2O3S, CAS 433943-04-5
4-Methyl-3-({[(2E)-3-phenylprop-2-enoyl]carbamothioyl}amino)benzoic acid
CAS 433943-04-5C18H16N2O3S
3-({[(2E)-3-Phenylprop-2-enoyl]carbamothioyl}amino)benzoic acid chemical structure, C17H14N2O3S, CAS 433697-63-3
3-({[(2E)-3-Phenylprop-2-enoyl]carbamothioyl}amino)benzoic acid
CAS 433697-63-3C17H14N2O3S
(E)-N-[(2-Methoxyphenyl)carbamothioyl]-3-phenylprop-2-enamide chemical structure, C17H16N2O2S, CAS 425373-20-2
(E)-N-[(2-Methoxyphenyl)carbamothioyl]-3-phenylprop-2-enamide
CAS 425373-20-2C17H16N2O2S
(E)-N-[(3-Chloro-4-methoxyphenyl)carbamothioyl]-3-phenylprop-2-enamide chemical structure, C17H15ClN2O2S, CAS 425373-75-7
(E)-N-[(3-Chloro-4-methoxyphenyl)carbamothioyl]-3-phenylprop-2-enamide
CAS 425373-75-7C17H15ClN2O2S
(2E)-N-[(2,4-Dimethylphenyl)carbamothioyl]-3-phenylprop-2-enamide chemical structure, C18H18N2OS, CAS 347314-43-6
(2E)-N-[(2,4-Dimethylphenyl)carbamothioyl]-3-phenylprop-2-enamide
CAS 347314-43-6C18H18N2OS
(E)-N-[(2,5-Dimethylphenyl)carbamothioyl]-3-phenylprop-2-enamide chemical structure, C18H18N2OS, CAS 425400-83-5
(E)-N-[(2,5-Dimethylphenyl)carbamothioyl]-3-phenylprop-2-enamide
CAS 425400-83-5C18H18N2OS
(E)-N-[(2,5-Dimethoxyphenyl)carbamothioyl]-3-phenylprop-2-enamide chemical structure, C18H18N2O3S, CAS 6144-05-4
(E)-N-[(2,5-Dimethoxyphenyl)carbamothioyl]-3-phenylprop-2-enamide
CAS 6144-05-4C18H18N2O3S
N-(((4-Fluorophenyl)amino)thioxomethyl)-3-phenylprop-2-enamide chemical structure, C16H13FN2OS, CAS 347314-37-8
N-(((4-Fluorophenyl)amino)thioxomethyl)-3-phenylprop-2-enamide
CAS 347314-37-8C16H13FN2OS
(E)-N-[(4-Ethylphenyl)carbamothioyl]-3-phenylprop-2-enamide chemical structure, C18H18N2OS, CAS 425402-88-6
(E)-N-[(4-Ethylphenyl)carbamothioyl]-3-phenylprop-2-enamide
CAS 425402-88-6C18H18N2OS
Methyl 2-({[(2E)-3-phenylprop-2-enoyl]carbamothioyl}amino)benzoate chemical structure, C18H16N2O3S, CAS 355412-01-0
Methyl 2-({[(2E)-3-phenylprop-2-enoyl]carbamothioyl}amino)benzoate
CAS 355412-01-0C18H16N2O3S
(E)-N-[(3-Methylphenyl)carbamothioyl]-3-phenylprop-2-enamide chemical structure, C17H16N2OS, CAS 89373-82-0
(E)-N-[(3-Methylphenyl)carbamothioyl]-3-phenylprop-2-enamide
CAS 89373-82-0C17H16N2OS
(E)-N-[(3,4-Dimethylphenyl)carbamothioyl]-3-phenylprop-2-enamide chemical structure, C18H18N2OS, CAS 347314-48-1
(E)-N-[(3,4-Dimethylphenyl)carbamothioyl]-3-phenylprop-2-enamide
CAS 347314-48-1C18H18N2OS
(E)-3-(4-Chlorophenyl)-N-[(4-methoxyphenyl)carbamothioyl]prop-2-enamide chemical structure, C17H15ClN2O2S, CAS 364616-58-0
(E)-3-(4-Chlorophenyl)-N-[(4-methoxyphenyl)carbamothioyl]prop-2-enamide
CAS 364616-58-0C17H15ClN2O2S
(E)-3-(4-Chlorophenyl)-N-[(3,4-dimethylphenyl)carbamothioyl]prop-2-enamide chemical structure, C18H17ClN2OS, CAS 364628-25-1
(E)-3-(4-Chlorophenyl)-N-[(3,4-dimethylphenyl)carbamothioyl]prop-2-enamide
CAS 364628-25-1C18H17ClN2OS
(E)-3-(4-Chlorophenyl)-N-[(2-methylphenyl)carbamothioyl]prop-2-enamide chemical structure, C17H15ClN2OS, CAS 364617-94-7
(E)-3-(4-Chlorophenyl)-N-[(2-methylphenyl)carbamothioyl]prop-2-enamide
CAS 364617-94-7C17H15ClN2OS
(E)-3-(4-Chlorophenyl)-N-[(2-methoxyphenyl)carbamothioyl]prop-2-enamide chemical structure, C17H15ClN2O2S, CAS 401615-31-4
(E)-3-(4-Chlorophenyl)-N-[(2-methoxyphenyl)carbamothioyl]prop-2-enamide
CAS 401615-31-4C17H15ClN2O2S
(E)-N-[(2,4-Dimethoxyphenyl)carbamothioyl]-3-phenylprop-2-enamide chemical structure, C18H18N2O3S, CAS 364620-29-1
(E)-N-[(2,4-Dimethoxyphenyl)carbamothioyl]-3-phenylprop-2-enamide
CAS 364620-29-1C18H18N2O3S
(E)-N-[(2-Hydroxy-4,5-dimethylphenyl)carbamothioyl]-3-phenylprop-2-enamide chemical structure, C18H18N2O2S, CAS 364737-53-1
(E)-N-[(2-Hydroxy-4,5-dimethylphenyl)carbamothioyl]-3-phenylprop-2-enamide
CAS 364737-53-1C18H18N2O2S