Murcko scaffold
Ring system with 2 rings and 10 atoms
105 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 10
- Chemicals
- 105
- With full pages
- 6
Scaffold SMILES
c1coc(-c2ccsc2)c1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 105 chemicals
Ethyl 2-amino-4-(5-methylfuran-2-yl)thiophene-3-carboxylate
CAS 378196-87-3C12H13NO3S
Ethyl 2-amino-4-(2-furyl)thiophene-3-carboxylate
CAS 256506-99-7C11H11NO3S
Ethyl 2-(2-chloroacetamido)-4-(furan-2-yl)thiophene-3-carboxylate
CAS 356568-72-4C13H12ClNO4S
Ethyl 2-(dimethylcarbamoylcarbamothioylamino)-4-(5-methylfuran-2-yl)thiophene-3-carboxylate
CAS 713112-91-5C16H19N3O4S2
Methyl 2-amino-4-(furan-2-yl)thiophene-3-carboxylate
CAS 670271-04-2C10H9NO3S
![Methyl 3-(5-{[(2,2-dimethylpropanoyl)oxy]methyl}-2-furyl)-2-thiophenecarboxylate chemical structure, C16H18O5S, CAS 320418-20-0](/s/HRFSUXSGVWGGFB-UHFFFAOYSA-N.svg)
Methyl 3-(5-{[(2,2-dimethylpropanoyl)oxy]methyl}-2-furyl)-2-thiophenecarboxylate
CAS 320418-20-0C16H18O5S
![Methyl 3-(5-{[(2-chloroacetyl)oxy]methyl}-2-furyl)-2-thiophenecarboxylate chemical structure, C13H11ClO5S, CAS 320418-21-1](/s/LLDZSFNWVCFMRD-UHFFFAOYSA-N.svg)
Methyl 3-(5-{[(2-chloroacetyl)oxy]methyl}-2-furyl)-2-thiophenecarboxylate
CAS 320418-21-1C13H11ClO5S
![Ethyl 2-[(chloroacetyl)amino]-4-(5-methyl-2-furyl)thiophene-3-carboxylate chemical structure, C14H14ClNO4S, CAS 736960-88-6](/s/LTXQOUSIXFNKLV-UHFFFAOYSA-N.svg)
Ethyl 2-[(chloroacetyl)amino]-4-(5-methyl-2-furyl)thiophene-3-carboxylate
CAS 736960-88-6C14H14ClNO4S
![Methyl 3-[5-(2,2-dicyanovinyl)-2-furyl]-2-thiophenecarboxylate chemical structure, C14H8N2O3S, CAS 136428-42-7](/s/FMRSKLJWKKKAGG-UHFFFAOYSA-N.svg)
Methyl 3-[5-(2,2-dicyanovinyl)-2-furyl]-2-thiophenecarboxylate
CAS 136428-42-7C14H8N2O3S
![5-[2-(Methoxycarbonyl)-3-thienyl]-2-furoic acid chemical structure, C11H8O5S, CAS 241488-17-5](/s/YENXSQRGGUCQBA-UHFFFAOYSA-N.svg)
5-[2-(Methoxycarbonyl)-3-thienyl]-2-furoic acid
CAS 241488-17-5C11H8O5S
Methyl 3-(5-(2-cyano-3-ethoxy-3-oxo-1-propen-1-yl)-2-furanyl)-2-thiophenecarboxylate
CAS 241488-29-9C16H13NO5S
![Diethyl 2-({5-[2-(methoxycarbonyl)-3-thienyl]-2-furyl}methylene)malonate chemical structure, C18H18O7S, CAS 241488-43-7](/s/NCSKTWLJWAQFHC-UHFFFAOYSA-N.svg)
Diethyl 2-({5-[2-(methoxycarbonyl)-3-thienyl]-2-furyl}methylene)malonate
CAS 241488-43-7C18H18O7S
![Methyl 3-[5-(2-acetyl-3-oxo-1-butenyl)-2-furyl]-2-thiophenecarboxylate chemical structure, C16H14O5S, CAS 241488-50-6](/s/DCIMVCDFGROIMA-UHFFFAOYSA-N.svg)
Methyl 3-[5-(2-acetyl-3-oxo-1-butenyl)-2-furyl]-2-thiophenecarboxylate
CAS 241488-50-6C16H14O5S
![Methyl 3-[5-(methylcarbamoyl)furan-2-yl]thiophene-2-carboxylate chemical structure, C12H11NO4S, CAS 477851-64-2](/s/BKUOOVDLYSRPQO-UHFFFAOYSA-N.svg)
Methyl 3-[5-(methylcarbamoyl)furan-2-yl]thiophene-2-carboxylate
CAS 477851-64-2C12H11NO4S
Methyl5-(2-(methoxycarbonyl)-3-thienyl)-2-furoate
CAS 477851-73-3C12H10O5S
Methyl 3-(5-carbamoylfuran-2-yl)thiophene-2-carboxylate
CAS 477851-82-4C11H9NO4S
Butyl5-(2-(methoxycarbonyl)-3-thienyl)-2-furoate
CAS 477851-83-5C15H16O5S
Methyl 3-(5-formylfuran-2-yl)thiophene-2-carboxylate
CAS 255828-29-6C11H8O4S
Methyl 3-(5-formylfuran-2-yl)-4-methylthiophene-2-carboxylate
CAS 259683-27-7C12H10O4S
5-Thiophen-3-yl-furan-2-carboxylic acid
CAS 560993-95-5C9H6O3S
5-(3-Thienyl)-2-furaldehyde
CAS 886361-73-5C9H6O2S
![Methyl 3-{5-[(E)-2-nitroethenyl]furan-2-yl}thiophene-2-carboxylate chemical structure, C12H9NO5S, CAS 241488-42-6](/s/JIAGGNSLDSCFSX-GQCTYLIASA-N.svg)
Methyl 3-{5-[(E)-2-nitroethenyl]furan-2-yl}thiophene-2-carboxylate
CAS 241488-42-6C12H9NO5S
![Methyl 3-[5-(2-cyano-3-ethoxy-3-oxo-1-propenyl)-2-furyl]-2-thiophenecarboxylate chemical structure, C16H13NO5S, CAS 1164486-33-2](/s/QHISWGCVIQCFQD-CSKARUKUSA-N.svg)
Methyl 3-[5-(2-cyano-3-ethoxy-3-oxo-1-propenyl)-2-furyl]-2-thiophenecarboxylate
CAS 1164486-33-2C16H13NO5S
![Methyl 3-[5-[(E)-2-ethoxycarbonyl-3-oxobut-1-enyl]furan-2-yl]thiophene-2-carboxylate chemical structure, C17H16O6S, CAS 241488-49-3](/s/SXOCNDNSYKTLRM-UKTHLTGXSA-N.svg)
Methyl 3-[5-[(E)-2-ethoxycarbonyl-3-oxobut-1-enyl]furan-2-yl]thiophene-2-carboxylate
CAS 241488-49-3C17H16O6S
- Methyl3-(5-((methoxyimino)methyl)-2-furyl)-2-thiophenecarboxylate241488-19-7C12H11NO4S
- Methyl3-(5-((hydroxyimino)methyl)-2-furyl)-2-thiophenecarboxylate338976-22-0C11H9NO4S
- 2-Amino-4-(2-furyl)thiophene-3-carbonitrile82039-31-4C9H6N2OS
- 3-(5-Formylfuran-2-yl)thiophene-2-carboxylic acid2137615-49-5C10H6O4S
- 5-(5-Formylthiophen-3-yl)furan-2-carboxylic acid893729-93-6C10H6O4S
- 4-(Furan-2-yl)thiophene-2-carboxylic acid893727-89-4C9H6O3S
- 4-(Furan-2-yl)thiophene-2-carbaldehyde893735-78-9C9H6O2S
- Methyl 2-amino-4-(5-methylfuran-2-yl)thiophene-3-carboxylate1019521-41-5C11H11NO3S
- 3-(5-Methylfuran-2-yl)thiophene-2-carboxylic acid2107535-57-7C10H8O3S
- 3-(Furan-2-yl)thiophene-2-carboxylic acid1342440-84-9C9H6O3S
- (4-(Furan-2-yl)thiophen-2-yl)methanamine1342096-79-0C9H9NOS
- 5-(5-Methylthiophen-3-yl)furan-2-carboxylic acid1492589-39-5C10H8O3S
- 2-Amino-4-(2-furyl)thiophene-3-carboxylic acid1428141-37-0C9H7NO3S
- [5-(Thiophen-3-yl)furan-2-yl]methanamine1694054-85-7C9H9NOS
- tert-Butyl 2-amino-4-(furan-2-yl)thiophene-3-carboxylate1552698-63-1C13H15NO3S
- tert-Butyl 2-amino-4-(5-methylfuran-2-yl)thiophene-3-carboxylate1554395-80-0C14H17NO3S
- 5-(2-Methylthiophen-3-yl)furan-2-carboxylic acid1601767-07-0C10H8O3S
- 5-(2-Methylthiophen-3-yl)furan-2-carbaldehyde1695866-12-6C10H8O2S
- 1-((2-Hydroxy-2-(5-(thiophen-3-yl)furan-2-yl)ethyl)amino)-2-methyl-1-oxopropan-2-yl acetate2034490-69-0C16H19NO5S
- N1-(2-hydroxy-2-(5-(thiophen-3-yl)furan-2-yl)ethyl)oxalamide2034253-58-0C12H12N2O4S
- N-((5-(Thiophen-3-yl)furan-2-yl)methyl)acetamide2034492-13-0C11H11NO2S
- Methyl ((5-(thiophen-3-yl)furan-2-yl)methyl)carbamate2034253-24-0C11H11NO3S
- N-((5-(Thiophen-3-yl)furan-2-yl)methyl)butyramide2034438-15-6C13H15NO2S
- N-((5-(Thiophen-3-yl)furan-2-yl)methyl)isobutyramide2034253-31-9C13H15NO2S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold c1n[nH]cc1B1OCCO1](/scaffold/BMQOPKIAPDKYOJ-UHFFFAOYSA-N/structure.svg)
c1n[nH]cc1B1OCCO163 chemicals
c1csc(-c2cccs2)c148 chemicals
c1cnn(C2CCCC2)c143 chemicals![Scaffold c1cc(B2OCCO2)n[nH]1](/scaffold/INSYJPNIRNOISO-UHFFFAOYSA-N/structure.svg)
c1cc(B2OCCO2)n[nH]142 chemicals![Scaffold c1csc(-c2cc[nH]n2)c1](/scaffold/TVNDPZYOQCCHTJ-UHFFFAOYSA-N/structure.svg)
c1csc(-c2cc[nH]n2)c135 chemicals
c1ncc(B2OCCO2)s130 chemicals
c1csc(B2OCCO2)c127 chemicals
c1csc(-c2cscn2)c123 chemicals
c1csc(-c2ccno2)c122 chemicals![Scaffold c1coc(-c2cc[nH]n2)c1](/scaffold/XHTWJTDNZKWQON-UHFFFAOYSA-N/structure.svg)
c1coc(-c2cc[nH]n2)c122 chemicals
c1cc(B2OCCO2)cs120 chemicals
c1cn(C2CCCO2)cn119 chemicals