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Murcko scaffold

1-(3,4-Dihydroisoquinolin-2(1H)-yl)-3-phenylprop-2-en-1-one scaffold

9 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
9
With full pages
6
Scaffold SMILES

O=C(C=Cc1ccccc1)N1CCc2ccccc2C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(3,4-Dihydroisoquinolin-2(1H)-yl)-3-phenylprop-2-en-1-one page
Murcko scaffold O=C(C=Cc1ccccc1)N1CCc2ccccc2C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

1-(3,4-Dihydroisoquinolin-2(1H)-yl)-3-phenylprop-2-en-1-one chemical structure, C18H17NO, CAS 10579-65-4
1-(3,4-Dihydroisoquinolin-2(1H)-yl)-3-phenylprop-2-en-1-one
CAS 10579-65-4C18H17NO
(E)-1-(3,4-Dihydro-1H-isoquinolin-2-yl)-3-(2-nitrophenyl)prop-2-en-1-one chemical structure, C18H16N2O3, CAS 600123-31-7
(E)-1-(3,4-Dihydro-1H-isoquinolin-2-yl)-3-(2-nitrophenyl)prop-2-en-1-one
CAS 600123-31-7C18H16N2O3
(E)-3-(2-Chloro-6-fluorophenyl)-1-(3,4-dihydro-1H-isoquinolin-2-yl)prop-2-en-1-one chemical structure, C18H15ClFNO, CAS 540532-85-2
(E)-3-(2-Chloro-6-fluorophenyl)-1-(3,4-dihydro-1H-isoquinolin-2-yl)prop-2-en-1-one
CAS 540532-85-2C18H15ClFNO
2-[3-(4-Methylphenyl)acryloyl]-1,2,3,4-tetrahydroisoquinoline chemical structure, C19H19NO, CAS 1164506-14-2
2-[3-(4-Methylphenyl)acryloyl]-1,2,3,4-tetrahydroisoquinoline
CAS 1164506-14-2C19H19NO
2-[3-(4-Isopropylphenyl)acryloyl]-1,2,3,4-tetrahydroisoquinoline chemical structure, C21H23NO, CAS 1164493-83-7
2-[3-(4-Isopropylphenyl)acryloyl]-1,2,3,4-tetrahydroisoquinoline
CAS 1164493-83-7C21H23NO
(Z)-1-(3,4-Dihydro-1H-isoquinolin-2-yl)-3-phenylprop-2-en-1-one chemical structure, C18H17NO
(Z)-1-(3,4-Dihydro-1H-isoquinolin-2-yl)-3-phenylprop-2-en-1-one
C18H17NO
(E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(4-fluorophenyl)prop-2-en-1-one chemical structure, C20H20FNO3, CAS 781631-89-8
(E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(4-fluorophenyl)prop-2-en-1-one
CAS 781631-89-8C20H20FNO3
(E)-1-(3,4-Dihydro-1H-isoquinolin-2-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one chemical structure, C21H23NO4, CAS 431995-30-1
(E)-1-(3,4-Dihydro-1H-isoquinolin-2-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
CAS 431995-30-1C21H23NO4
3-(4-Bromo-3-chlorophenyl)-1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-2-propen-1-one chemical structure, C20H19BrClNO3, CAS 879350-78-4
3-(4-Bromo-3-chlorophenyl)-1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-2-propen-1-one
CAS 879350-78-4C20H19BrClNO3