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Murcko scaffold

Ring system with 3 rings and 21 atoms

13 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
13
With full pages
4
Scaffold SMILES

O=C(Nc1ccccc1N1CCNCC1)c1cccnc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1N1CCNCC1)c1cccnc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

N-[3-Chloro-2-(4-ethylpiperazin-1-yl)phenyl]pyridine-3-carboxamide chemical structure, C18H21ClN4O, CAS 712284-48-5
N-[3-Chloro-2-(4-ethylpiperazin-1-yl)phenyl]pyridine-3-carboxamide
CAS 712284-48-5C18H21ClN4O
2-Chloro-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]pyridine-3-carboxamide chemical structure, C17H19ClN4O3S, CAS 724449-51-8
2-Chloro-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]pyridine-3-carboxamide
CAS 724449-51-8C17H19ClN4O3S
N-{2-[4-(Methylsulfonyl)-1-piperazinyl]phenyl}nicotinamide chemical structure, C17H20N4O3S, CAS 712284-50-9
N-{2-[4-(Methylsulfonyl)-1-piperazinyl]phenyl}nicotinamide
CAS 712284-50-9C17H20N4O3S
2-Chloro-N-[2-(4-methylpiperazin-1-yl)phenyl]pyridine-3-carboxamide chemical structure, C17H19ClN4O, CAS 400076-95-1
2-Chloro-N-[2-(4-methylpiperazin-1-yl)phenyl]pyridine-3-carboxamide
CAS 400076-95-1C17H19ClN4O
Methyl 4-(4-methylpiperazin-1-yl)-3-(pyridine-3-carbonylamino)benzoate chemical structure, C19H22N4O3, CAS 876889-07-5
Methyl 4-(4-methylpiperazin-1-yl)-3-(pyridine-3-carbonylamino)benzoate
CAS 876889-07-5C19H22N4O3
N-[5-Chloro-2-(4-propanoylpiperazin-1-yl)phenyl]pyridine-3-carboxamide chemical structure, C19H21ClN4O2, CAS 714207-51-9
N-[5-Chloro-2-(4-propanoylpiperazin-1-yl)phenyl]pyridine-3-carboxamide
CAS 714207-51-9C19H21ClN4O2
N-[2-(4-Acetylpiperazin-1-yl)phenyl]pyridine-3-carboxamide chemical structure, C18H20N4O2, CAS 839690-67-4
N-[2-(4-Acetylpiperazin-1-yl)phenyl]pyridine-3-carboxamide
CAS 839690-67-4C18H20N4O2
Methyl 4-(4-acetylpiperazin-1-yl)-3-(pyridine-3-carbonylamino)benzoate chemical structure, C20H22N4O4, CAS 765934-62-1
Methyl 4-(4-acetylpiperazin-1-yl)-3-(pyridine-3-carbonylamino)benzoate
CAS 765934-62-1C20H22N4O4
5-Bromo-N-[3-chloro-2-(4-isobutyryl-1-piperazinyl)phenyl]nicotinamide chemical structure, C20H22BrClN4O2, CAS 920430-59-7
5-Bromo-N-[3-chloro-2-(4-isobutyryl-1-piperazinyl)phenyl]nicotinamide
CAS 920430-59-7C20H22BrClN4O2
N-[3-Chloro-2-[4-(2-methylpropanoyl)piperazin-1-yl]phenyl]pyridine-3-carboxamide chemical structure, C20H23ClN4O2, CAS 916035-76-2
N-[3-Chloro-2-[4-(2-methylpropanoyl)piperazin-1-yl]phenyl]pyridine-3-carboxamide
CAS 916035-76-2C20H23ClN4O2
N-[5-Chloro-2-(4-ethylpiperazin-1-yl)phenyl]-2-(methylsulfanyl)pyridine-3-carboxamide chemical structure, C19H23ClN4OS, CAS 1014537-91-7
N-[5-Chloro-2-(4-ethylpiperazin-1-yl)phenyl]-2-(methylsulfanyl)pyridine-3-carboxamide
CAS 1014537-91-7C19H23ClN4OS
N-[2-(4-Acetyl-1-piperazinyl)-3-chlorophenyl]nicotinamide chemical structure, C18H19ClN4O2, CAS 1030509-47-7
N-[2-(4-Acetyl-1-piperazinyl)-3-chlorophenyl]nicotinamide
CAS 1030509-47-7C18H19ClN4O2
N-[3-Chloro-2-(4-propanoylpiperazin-1-yl)phenyl]pyridine-3-carboxamide chemical structure, C19H21ClN4O2, CAS 1030534-18-9
N-[3-Chloro-2-(4-propanoylpiperazin-1-yl)phenyl]pyridine-3-carboxamide
CAS 1030534-18-9C19H21ClN4O2