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Murcko scaffold

Ring system with 3 rings and 19 atoms

204 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
204
With full pages
14
Scaffold SMILES

O=C1NC(=S)SC1=Cc1ccc(-c2ccccc2)o1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NC(=S)SC1=Cc1ccc(-c2ccccc2)o1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 204 chemicals

5-[[5-(2-Chlorophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid chemical structure, C17H12ClNO4S2, CAS 306279-32-3
5-[[5-(2-Chlorophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid
CAS 306279-32-3C17H12ClNO4S2
3-[(5E)-4-Oxo-2-thioxo-5-({5-[3-(trifluoromethyl)phenyl]furan-2-yl}methylidene)-1,3-thiazolidin-3-yl]propanoic acid chemical structure, C18H12F3NO4S2, CAS 851305-07-2
3-[(5E)-4-Oxo-2-thioxo-5-({5-[3-(trifluoromethyl)phenyl]furan-2-yl}methylidene)-1,3-thiazolidin-3-yl]propanoic acid
CAS 851305-07-2C18H12F3NO4S2
2-(5-(((5Z)-4-Oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid chemical structure, C15H9NO4S2, CAS 292640-28-9
2-(5-(((5Z)-4-Oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid
CAS 292640-28-9C15H9NO4S2
[4-Oxo-5-(5-phenyl-furan-2-ylmethylene)-2-thioxo-thiazolidin-3-yl]-acetic acid chemical structure, C16H11NO4S2, CAS 294657-85-5
[4-Oxo-5-(5-phenyl-furan-2-ylmethylene)-2-thioxo-thiazolidin-3-yl]-acetic acid
CAS 294657-85-5C16H11NO4S2
[4-Oxo-5-(5-phenylfuran-2-yl-methylene)-2-thioxothiazolidin-3-yl]acetic acid chemical structure, C16H11NO4S2
[4-Oxo-5-(5-phenylfuran-2-yl-methylene)-2-thioxothiazolidin-3-yl]acetic acid
C16H11NO4S2
[(5E)-5-{[5-(4-Chlorophenyl)furan-2-yl]methylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid chemical structure, C16H10ClNO4S2, CAS 691881-66-0
[(5E)-5-{[5-(4-Chlorophenyl)furan-2-yl]methylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
CAS 691881-66-0C16H10ClNO4S2
5-[(5-{2-Chloro-5-nitrophenyl}-2-furyl)methylene]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C14H7ClN2O4S2, CAS 331649-70-8
5-[(5-{2-Chloro-5-nitrophenyl}-2-furyl)methylene]-2-thioxo-1,3-thiazolidin-4-one
CAS 331649-70-8C14H7ClN2O4S2
[(5E)-5-{[5-(3-Chlorophenyl)furan-2-yl]methylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid chemical structure, C16H10ClNO4S2, CAS 324542-54-3
[(5E)-5-{[5-(3-Chlorophenyl)furan-2-yl]methylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
CAS 324542-54-3C16H10ClNO4S2
(5E)-5-[[5-(3-Chloro-4-methoxyphenyl)furan-2-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C15H10ClNO3S2, CAS 691881-69-3
(5E)-5-[[5-(3-Chloro-4-methoxyphenyl)furan-2-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 691881-69-3C15H10ClNO3S2
2-Thioxo-5-((5-(3-(trifluoromethyl)PH)-2-furyl)methylene)-1,3-thiazolidin-4-one chemical structure, C15H8F3NO2S2, CAS 301687-87-6
2-Thioxo-5-((5-(3-(trifluoromethyl)PH)-2-furyl)methylene)-1,3-thiazolidin-4-one
CAS 301687-87-6C15H8F3NO2S2
(E)-3-(5((5-(4-Chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid chemical structure, C17H12ClNO4S2, CAS 259811-86-4
(E)-3-(5((5-(4-Chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid
CAS 259811-86-4C17H12ClNO4S2
Claficapavir chemical structure, C17H12ClNO4S2, CAS 2055732-24-4
Claficapavir
CAS 2055732-24-4C17H12ClNO4S2
(5E)-5-{[5-(3-Chloro-4-methylphenyl)furan-2-yl]methylidene}-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C15H10ClNO2S2, CAS 299904-21-5
(5E)-5-{[5-(3-Chloro-4-methylphenyl)furan-2-yl]methylidene}-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 299904-21-5C15H10ClNO2S2
Methyl 4-[5-[(3-ethyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl]benzoate chemical structure, C18H15NO4S2
Methyl 4-[5-[(3-ethyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl]benzoate
C18H15NO4S2
Ask1-IN-4 chemical structure, C18H14BrNO4S2, CAS 1427538-26-8
Ask1-IN-4
CAS 1427538-26-8C18H14BrNO4S2
(5E)-5-[[5-(4-Fluorophenyl)furan-2-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C14H8FNO2S2, CAS 691881-80-8
(5E)-5-[[5-(4-Fluorophenyl)furan-2-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 691881-80-8C14H8FNO2S2
5-{[5-(2-Bromo-4,5-dimethylphenyl)-2-furyl]methylene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C16H12BrNO2S2, CAS 5988-55-6
5-{[5-(2-Bromo-4,5-dimethylphenyl)-2-furyl]methylene}-2-thioxo-1,3-thiazolidin-4-one
CAS 5988-55-6C16H12BrNO2S2
(E)-Methyl 2-(5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoate chemical structure, C16H11NO4S2, CAS 299904-39-5
(E)-Methyl 2-(5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoate
CAS 299904-39-5C16H11NO4S2
3-Allyl-5-{[5-(2-methyl-4-nitrophenyl)-2-furyl]methylene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C18H14N2O4S2, CAS 5730-97-2
3-Allyl-5-{[5-(2-methyl-4-nitrophenyl)-2-furyl]methylene}-2-thioxo-1,3-thiazolidin-4-one
CAS 5730-97-2C18H14N2O4S2
3-[(5Z)-5-{[5-(2,4-Dichlorophenyl)furan-2-yl]methylidene}-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid chemical structure, C17H11Cl2NO4S2, CAS 691881-60-4
3-[(5Z)-5-{[5-(2,4-Dichlorophenyl)furan-2-yl]methylidene}-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid
CAS 691881-60-4C17H11Cl2NO4S2
(5Z)-5-{[5-(4-Chloro-2-nitrophenyl)furan-2-yl]methylidene}-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C14H7ClN2O4S2, CAS 1321711-39-0
(5Z)-5-{[5-(4-Chloro-2-nitrophenyl)furan-2-yl]methylidene}-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 1321711-39-0C14H7ClN2O4S2
4-Thiazolidinone, 3-Methyl-2-thioxo-5-[[5-[3-(trifluoroMethyl)phenyl]-2-furanyl]Methylene]- chemical structure, C16H10F3NO2S2, CAS 313663-29-5
4-Thiazolidinone, 3-Methyl-2-thioxo-5-[[5-[3-(trifluoroMethyl)phenyl]-2-furanyl]Methylene]-
CAS 313663-29-5C16H10F3NO2S2
(5E)-5-[[5-(4-Methoxyphenyl)furan-2-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C15H11NO3S2, CAS 691881-82-0
(5E)-5-[[5-(4-Methoxyphenyl)furan-2-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 691881-82-0C15H11NO3S2
(5E)-5-[(5-Phenylfuran-2-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C14H9NO2S2, CAS 35274-41-0
(5E)-5-[(5-Phenylfuran-2-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 35274-41-0C14H9NO2S2