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Murcko scaffold

Ring system with 3 rings and 22 atoms

90 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
90
With full pages
3
Scaffold SMILES

O=C(NCc1n[nH]c(=S)n1-c1ccccc1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCc1n[nH]c(=S)n1-c1ccccc1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 90 of 90 chemicals

N-[[4-(4-Fluorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-3-methoxybenzamide chemical structure, C17H15FN4O2S, CAS 391886-78-5
N-[[4-(4-Fluorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-3-methoxybenzamide
CAS 391886-78-5C17H15FN4O2S
2,5-Dichloro-N-((5-thioxo-4-(m-tolyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide chemical structure, C17H14Cl2N4OS, CAS 391887-03-9
2,5-Dichloro-N-((5-thioxo-4-(m-tolyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide
CAS 391887-03-9C17H14Cl2N4OS
N-[[4-(3,4-Dichlorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-3,4,5-triethoxybenzamide chemical structure, C22H24Cl2N4O4S, CAS 391887-72-2
N-[[4-(3,4-Dichlorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-3,4,5-triethoxybenzamide
CAS 391887-72-2C22H24Cl2N4O4S
N-((4-(3,4-Dichlorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3-methylbenzamide chemical structure, C17H14Cl2N4OS, CAS 391886-59-2
N-((4-(3,4-Dichlorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3-methylbenzamide
CAS 391886-59-2C17H14Cl2N4OS
3-Methyl-N-((5-thioxo-4-(m-tolyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide chemical structure, C18H18N4OS, CAS 391886-63-8
3-Methyl-N-((5-thioxo-4-(m-tolyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide
CAS 391886-63-8C18H18N4OS
N-((4-(2-Methoxyphenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3,4-dimethylbenzamide chemical structure, C19H20N4O2S, CAS 391887-24-4
N-((4-(2-Methoxyphenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3,4-dimethylbenzamide
CAS 391887-24-4C19H20N4O2S
2-Fluoro-N-((4-(4-nitrophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide chemical structure, C16H12FN5O3S, CAS 392247-74-4
2-Fluoro-N-((4-(4-nitrophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide
CAS 392247-74-4C16H12FN5O3S
2-Chloro-6-fluoro-N-((4-(2-methoxyphenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide chemical structure, C17H14ClFN4O2S, CAS 391887-08-4
2-Chloro-6-fluoro-N-((4-(2-methoxyphenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide
CAS 391887-08-4C17H14ClFN4O2S
3,4-Dimethoxy-N-((5-thioxo-4-(m-tolyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide chemical structure, C19H20N4O3S, CAS 391887-60-8
3,4-Dimethoxy-N-((5-thioxo-4-(m-tolyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide
CAS 391887-60-8C19H20N4O3S
3,4,5-Trimethoxy-N-[[4-(4-nitrophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide chemical structure, C19H19N5O6S, CAS 392247-82-4
3,4,5-Trimethoxy-N-[[4-(4-nitrophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide
CAS 392247-82-4C19H19N5O6S
2-Methyl-N-[[4-(3-methylphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-3-nitrobenzamide chemical structure, C18H17N5O3S, CAS 391887-44-8
2-Methyl-N-[[4-(3-methylphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-3-nitrobenzamide
CAS 391887-44-8C18H17N5O3S
N-[[4-(4-Fluorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-3,4,5-trimethoxybenzamide chemical structure, C19H19FN4O4S, CAS 391887-67-5
N-[[4-(4-Fluorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-3,4,5-trimethoxybenzamide
CAS 391887-67-5C19H19FN4O4S
N-((4-(4-Fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3,4-dimethoxybenzamide chemical structure, C18H17FN4O3S, CAS 391887-59-5
N-((4-(4-Fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3,4-dimethoxybenzamide
CAS 391887-59-5C18H17FN4O3S
N-[[4-(3,4-Dichlorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-4-nitrobenzamide chemical structure, C16H11Cl2N5O3S, CAS 391886-51-4
N-[[4-(3,4-Dichlorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-4-nitrobenzamide
CAS 391886-51-4C16H11Cl2N5O3S
N-((4-(2,6-Diethylphenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3-fluorobenzamide chemical structure, C20H21FN4OS, CAS 391886-48-9
N-((4-(2,6-Diethylphenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3-fluorobenzamide
CAS 391886-48-9C20H21FN4OS
4-(Dipropylsulfamoyl)-N-[(4-phenyl-5-sulfanylidene-1H-1,2,4-triazol-3-yl)methyl]benzamide chemical structure, C22H27N5O3S2, CAS 392247-42-6
4-(Dipropylsulfamoyl)-N-[(4-phenyl-5-sulfanylidene-1H-1,2,4-triazol-3-yl)methyl]benzamide
CAS 392247-42-6C22H27N5O3S2
N-[[4-(2-Methoxyphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-3-methylbenzamide chemical structure, C18H18N4O2S, CAS 391886-60-5
N-[[4-(2-Methoxyphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-3-methylbenzamide
CAS 391886-60-5C18H18N4O2S
N-[[4-(4-Fluorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-3-methylbenzamide chemical structure, C17H15FN4OS, CAS 391886-62-7
N-[[4-(4-Fluorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-3-methylbenzamide
CAS 391886-62-7C17H15FN4OS
4-(N,N-Dimethylsulfamoyl)-N-((4-(4-methoxyphenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide chemical structure, C19H21N5O4S2, CAS 392247-67-5
4-(N,N-Dimethylsulfamoyl)-N-((4-(4-methoxyphenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide
CAS 392247-67-5C19H21N5O4S2
3,4-Dimethyl-N-((5-thioxo-4-(m-tolyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide chemical structure, C19H20N4OS, CAS 391887-27-7
3,4-Dimethyl-N-((5-thioxo-4-(m-tolyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide
CAS 391887-27-7C19H20N4OS
3-Methoxy-N-[[4-(4-nitrophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide chemical structure, C17H15N5O4S, CAS 392247-75-5
3-Methoxy-N-[[4-(4-nitrophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide
CAS 392247-75-5C17H15N5O4S
2,5-Dichloro-N-[[4-(3,4-dichlorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide chemical structure, C16H10Cl4N4OS, CAS 391886-99-0
2,5-Dichloro-N-[[4-(3,4-dichlorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide
CAS 391886-99-0C16H10Cl4N4OS
N-[[4-(4-Methoxyphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-4-nitrobenzamide chemical structure, C17H15N5O4S, CAS 392247-63-1
N-[[4-(4-Methoxyphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-4-nitrobenzamide
CAS 392247-63-1C17H15N5O4S
3,4,5-Triethoxy-N-[[5-sulfanylidene-4-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-3-yl]methyl]benzamide chemical structure, C23H25F3N4O4S, CAS 391887-77-7
3,4,5-Triethoxy-N-[[5-sulfanylidene-4-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-3-yl]methyl]benzamide
CAS 391887-77-7C23H25F3N4O4S