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Murcko scaffold

4H,5H-(1,2,4)Triazolo(4,3-a)quinazolin-5-one scaffold

52 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
14
Chemicals
52
With full pages
12
Scaffold SMILES

O=c1[nH]c2nncn2c2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4H,5H-(1,2,4)Triazolo(4,3-a)quinazolin-5-one page
Murcko scaffold O=c1[nH]c2nncn2c2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 52 chemicals

1-(Chloromethyl)-4-pentyl-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C15H17ClN4O, CAS 771499-33-3
1-(Chloromethyl)-4-pentyl-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 771499-33-3C15H17ClN4O
1-(Chloromethyl)-4-(3-methylbutyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one chemical structure, C15H17ClN4O, CAS 757192-73-7
1-(Chloromethyl)-4-(3-methylbutyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one
CAS 757192-73-7C15H17ClN4O
N-Methyl-2-[(5-oxo-4-prop-2-enyl-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)sulfanyl]acetamide chemical structure, C15H15N5O2S, CAS 730250-17-6
N-Methyl-2-[(5-oxo-4-prop-2-enyl-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)sulfanyl]acetamide
CAS 730250-17-6C15H15N5O2S
[(4-Allyl-5-oxo-4,5-dihydro[1,2,4]triazolo[4,3-a]quinazolin-1-yl)thio]acetic acid chemical structure, C14H12N4O3S, CAS 742094-79-7
[(4-Allyl-5-oxo-4,5-dihydro[1,2,4]triazolo[4,3-a]quinazolin-1-yl)thio]acetic acid
CAS 742094-79-7C14H12N4O3S
2-[(5-Oxo-4-propyl-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)sulfanyl]acetamide chemical structure, C14H15N5O2S, CAS 869710-90-7
2-[(5-Oxo-4-propyl-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)sulfanyl]acetamide
CAS 869710-90-7C14H15N5O2S
2-({5-Oxo-4-propyl-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl}sulfanyl)acetonitrile chemical structure, C14H13N5OS, CAS 850032-29-0
2-({5-Oxo-4-propyl-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl}sulfanyl)acetonitrile
CAS 850032-29-0C14H13N5OS
1-(Chloromethyl)-4-methyl-4H,5H-(1,2,4)triazolo(4,3-a)quinazolin-5-one chemical structure, C11H9ClN4O, CAS 86671-88-7
1-(Chloromethyl)-4-methyl-4H,5H-(1,2,4)triazolo(4,3-a)quinazolin-5-one
CAS 86671-88-7C11H9ClN4O
4-Methyl[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one chemical structure, C10H8N4O, CAS 127570-97-2
4-Methyl[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one
CAS 127570-97-2C10H8N4O
1-(2-Oxopropylsulfanyl)-4-prop-2-enyl-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C15H14N4O2S, CAS 878616-44-5
1-(2-Oxopropylsulfanyl)-4-prop-2-enyl-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 878616-44-5C15H14N4O2S
3-[4-(3-Isopropoxypropyl)-5-oxo-4,5-dihydro[1,2,4]triazolo[4,3-a]quinazolin-1-yl]-N-(3-methylbutyl)propanamide chemical structure, C23H33N5O3, CAS 895648-24-5
3-[4-(3-Isopropoxypropyl)-5-oxo-4,5-dihydro[1,2,4]triazolo[4,3-a]quinazolin-1-yl]-N-(3-methylbutyl)propanamide
CAS 895648-24-5C23H33N5O3
4-Amino-1-(methylsulfanyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one chemical structure, C10H9N5OS, CAS 112752-65-5
4-Amino-1-(methylsulfanyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one
CAS 112752-65-5C10H9N5OS
4-Amino-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one chemical structure, C9H7N5O, CAS 112617-23-9
4-Amino-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one
CAS 112617-23-9C9H7N5O
2-[(5-Oxo-4-prop-2-enyl-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)sulfanyl]propanamide chemical structure, C15H15N5O2S, CAS 871906-93-3
2-[(5-Oxo-4-prop-2-enyl-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)sulfanyl]propanamide
CAS 871906-93-3C15H15N5O2S
1-Methylsulfanyl-4-propyl-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C13H14N4OS, CAS 923783-24-8
1-Methylsulfanyl-4-propyl-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 923783-24-8C13H14N4OS
1-(Chloromethyl)-4-ethyl-4H,5H-(1,2,4)triazolo(4,3-a)quinazolin-5-one chemical structure, C12H11ClN4O, CAS 86662-61-5
1-(Chloromethyl)-4-ethyl-4H,5H-(1,2,4)triazolo(4,3-a)quinazolin-5-one
CAS 86662-61-5C12H11ClN4O
N-(3-Methylbutyl)-3-[4-(2-methylpropyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide chemical structure, C21H29N5O2, CAS 902928-75-0
N-(3-Methylbutyl)-3-[4-(2-methylpropyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide
CAS 902928-75-0C21H29N5O2
1-((Cyanomethyl)thio)-4-isobutyl-N-isopropyl-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide chemical structure, C19H22N6O2S, CAS 1105231-90-0
1-((Cyanomethyl)thio)-4-isobutyl-N-isopropyl-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide
CAS 1105231-90-0C19H22N6O2S
1-((2-Amino-2-oxoethyl)thio)-4-isobutyl-N-isopropyl-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide chemical structure, C19H24N6O3S, CAS 1105220-75-4
1-((2-Amino-2-oxoethyl)thio)-4-isobutyl-N-isopropyl-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide
CAS 1105220-75-4C19H24N6O3S
4-(2-Methylpropyl)-5-oxo-N-(propan-2-yl)-1-({[(propan-2-yl)carbamoyl]methyl}sulfanyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide chemical structure, C22H30N6O3S, CAS 1105231-97-7
4-(2-Methylpropyl)-5-oxo-N-(propan-2-yl)-1-({[(propan-2-yl)carbamoyl]methyl}sulfanyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide
CAS 1105231-97-7C22H30N6O3S
1-(Chloromethyl)-4,7-dimethyl-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C12H11ClN4O, CAS 1114824-01-9
1-(Chloromethyl)-4,7-dimethyl-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 1114824-01-9C12H11ClN4O
N-(1-Cyano-1,2-dimethylpropyl)-2-({5-oxo-4-propyl-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl}sulfanyl)propanamide chemical structure, C21H26N6O2S, CAS 1111564-66-9
N-(1-Cyano-1,2-dimethylpropyl)-2-({5-oxo-4-propyl-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl}sulfanyl)propanamide
CAS 1111564-66-9C21H26N6O2S
N-(Butan-2-yl)-1-[(carbamoylmethyl)sulfanyl]-5-oxo-4-propyl-4H,5H-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide chemical structure, C19H24N6O3S, CAS 1105201-79-3
N-(Butan-2-yl)-1-[(carbamoylmethyl)sulfanyl]-5-oxo-4-propyl-4H,5H-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide
CAS 1105201-79-3C19H24N6O3S
N-(sec-Butyl)-2-((7-chloro-5-oxo-4-propyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)thio)acetamide chemical structure, C18H22ClN5O2S, CAS 1111039-29-2
N-(sec-Butyl)-2-((7-chloro-5-oxo-4-propyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)thio)acetamide
CAS 1111039-29-2C18H22ClN5O2S
2-((7-Chloro-5-oxo-4-propyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)thio)-N-isopropylacetamide chemical structure, C17H20ClN5O2S, CAS 1111176-12-5
2-((7-Chloro-5-oxo-4-propyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)thio)-N-isopropylacetamide
CAS 1111176-12-5C17H20ClN5O2S