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Murcko scaffold

4-Benzylpiperazinyl 2-thienyl ketone scaffold

29 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 20
Chemicals: 29
With full pages: 9

Scaffold SMILES

O=C(c1cccs1)N1CCN(Cc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 4-Benzylpiperazinyl 2-thienyl ketone page

Murcko scaffold O=C(c1cccs1)N1CCN(Cc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

[4-[(3-Methoxyphenyl)methyl]piperazin-1-yl]-thiophen-2-ylmethanone chemical structure, C17H20N2O2S, CAS 380625-32-1

[4-[(3-Methoxyphenyl)methyl]piperazin-1-yl]-thiophen-2-ylmethanone

CAS 380625-32-1C₁₇H₂₀N₂O₂S

[4-[(2-Methoxyphenyl)methyl]piperazin-1-yl]-thiophen-2-ylmethanone chemical structure, C17H20N2O2S, CAS 423748-20-3

[4-[(2-Methoxyphenyl)methyl]piperazin-1-yl]-thiophen-2-ylmethanone

CAS 423748-20-3C₁₇H₂₀N₂O₂S

[4-[(2,3-Dimethoxyphenyl)methyl]piperazin-1-yl]-thiophen-2-ylmethanone chemical structure, C18H22N2O3S, CAS 423742-49-8

[4-[(2,3-Dimethoxyphenyl)methyl]piperazin-1-yl]-thiophen-2-ylmethanone

CAS 423742-49-8C₁₈H₂₂N₂O₃S

[4-[(2,4-Dimethoxyphenyl)methyl]piperazin-1-yl]-thiophen-2-ylmethanone chemical structure, C18H22N2O3S, CAS 425397-00-8

[4-[(2,4-Dimethoxyphenyl)methyl]piperazin-1-yl]-thiophen-2-ylmethanone

CAS 425397-00-8C₁₈H₂₂N₂O₃S

4-Benzylpiperazinyl 2-thienyl ketone chemical structure, C16H18N2OS, CAS 314263-58-6

4-Benzylpiperazinyl 2-thienyl ketone

CAS 314263-58-6C₁₆H₁₈N₂OS

1-(4-Ethylbenzyl)-4-(2-thienylcarbonyl)piperazine chemical structure, C18H22N2OS, CAS 461402-34-6

1-(4-Ethylbenzyl)-4-(2-thienylcarbonyl)piperazine

CAS 461402-34-6C₁₈H₂₂N₂OS

1-(2-Chlorobenzyl)-4-(2-thienylcarbonyl)piperazine chemical structure, C16H17ClN2OS, CAS 461411-71-2

1-(2-Chlorobenzyl)-4-(2-thienylcarbonyl)piperazine

CAS 461411-71-2C₁₆H₁₇ClN₂OS

[4-(3-Chlorobenzyl)piperazin-1-yl](thiophen-2-yl)methanone chemical structure, C16H17ClN2OS, CAS 356075-85-9

[4-(3-Chlorobenzyl)piperazin-1-yl](thiophen-2-yl)methanone

CAS 356075-85-9C₁₆H₁₇ClN₂OS

[4-(3-Methylbenzyl)piperazin-1-yl](thiophen-2-yl)methanone chemical structure, C17H20N2OS, CAS 425391-14-6

[4-(3-Methylbenzyl)piperazin-1-yl](thiophen-2-yl)methanone

CAS 425391-14-6C₁₇H₂₀N₂OS

1-(2-Methylbenzyl)-4-(2-thienylcarbonyl)piperazine chemical structure, C17H20N2OS, CAS 423741-54-2

1-(2-Methylbenzyl)-4-(2-thienylcarbonyl)piperazine

CAS 423741-54-2C₁₇H₂₀N₂OS

1-(4-Methylbenzyl)-4-(2-thienylcarbonyl)piperazine chemical structure, C17H20N2OS, CAS 425397-93-9

1-(4-Methylbenzyl)-4-(2-thienylcarbonyl)piperazine

CAS 425397-93-9C₁₇H₂₀N₂OS

[4-[(3,4-Dimethoxyphenyl)methyl]piperazin-1-yl]-thiophen-2-ylmethanone chemical structure, C18H22N2O3S, CAS 425397-59-7

[4-[(3,4-Dimethoxyphenyl)methyl]piperazin-1-yl]-thiophen-2-ylmethanone

CAS 425397-59-7C₁₈H₂₂N₂O₃S

[4-(4-Ethoxybenzyl)piperazino](2-thienyl)methanone chemical structure, C18H22N2O2S, CAS 441314-57-4

[4-(4-Ethoxybenzyl)piperazino](2-thienyl)methanone

CAS 441314-57-4C₁₈H₂₂N₂O₂S

1-(2-Fluorobenzyl)-4-(2-thienylcarbonyl)piperazine chemical structure, C16H17FN2OS, CAS 423742-12-5

1-(2-Fluorobenzyl)-4-(2-thienylcarbonyl)piperazine

CAS 423742-12-5C₁₆H₁₇FN₂OS

[4-[(4-Methylsulfanylphenyl)methyl]piperazin-1-yl]-thiophen-2-ylmethanone chemical structure, C17H20N2OS2, CAS 423741-83-7

[4-[(4-Methylsulfanylphenyl)methyl]piperazin-1-yl]-thiophen-2-ylmethanone

CAS 423741-83-7C₁₇H₂₀N₂OS₂

1-(4-Chlorobenzyl)-4-(2-thienylcarbonyl)piperazine chemical structure, C16H17ClN2OS, CAS 423744-78-9

1-(4-Chlorobenzyl)-4-(2-thienylcarbonyl)piperazine

CAS 423744-78-9C₁₆H₁₇ClN₂OS

1-(3-Fluorobenzyl)-4-(2-thienylcarbonyl)piperazine chemical structure, C16H17FN2OS, CAS 504432-22-8

1-(3-Fluorobenzyl)-4-(2-thienylcarbonyl)piperazine

CAS 504432-22-8C₁₆H₁₇FN₂OS

[4-[(2-Nitrophenyl)methyl]piperazin-1-yl]-thiophen-2-ylmethanone chemical structure, C16H17N3O3S, CAS 625411-23-6

[4-[(2-Nitrophenyl)methyl]piperazin-1-yl]-thiophen-2-ylmethanone

CAS 625411-23-6C₁₆H₁₇N₃O₃S

1-(2-Bromobenzyl)-4-(2-thienylcarbonyl)piperazine chemical structure, C16H17BrN2OS, CAS 462616-98-4

1-(2-Bromobenzyl)-4-(2-thienylcarbonyl)piperazine

CAS 462616-98-4C₁₆H₁₇BrN₂OS

Thiophen-2-yl-[4-[(3,4,5-trimethoxyphenyl)methyl]piperazin-1-yl]methanone chemical structure, C19H24N2O4S, CAS 123947-35-3

Thiophen-2-yl-[4-[(3,4,5-trimethoxyphenyl)methyl]piperazin-1-yl]methanone

CAS 123947-35-3C₁₉H₂₄N₂O₄S

Thiophen-2-yl-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]methanone chemical structure, C19H24N2O4S, CAS 423743-91-3

Thiophen-2-yl-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]methanone

CAS 423743-91-3C₁₉H₂₄N₂O₄S

[4-[(3-Bromo-4-methoxyphenyl)methyl]piperazin-1-yl]-thiophen-2-ylmethanone chemical structure, C17H19BrN2O2S, CAS 425391-53-3

[4-[(3-Bromo-4-methoxyphenyl)methyl]piperazin-1-yl]-thiophen-2-ylmethanone

CAS 425391-53-3C₁₇H₁₉BrN₂O₂S

Thiophen-2-yl-[4-[(2,4,5-trimethoxyphenyl)methyl]piperazin-1-yl]methanone chemical structure, C19H24N2O4S, CAS 425397-61-1

Thiophen-2-yl-[4-[(2,4,5-trimethoxyphenyl)methyl]piperazin-1-yl]methanone

CAS 425397-61-1C₁₉H₂₄N₂O₄S

1-(5-Bromo-2-methoxybenzyl)-4-(2-thienylcarbonyl)piperazine chemical structure, C17H19BrN2O2S, CAS 423748-23-6

1-(5-Bromo-2-methoxybenzyl)-4-(2-thienylcarbonyl)piperazine

CAS 423748-23-6C₁₇H₁₉BrN₂O₂S