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Murcko scaffold

Ring system with 3 rings and 21 atoms

35 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
35
With full pages
14
Scaffold SMILES

O=C(c1ccccc1)N1CCN(C(=O)c2ccco2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)N1CCN(C(=O)c2ccco2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 35 of 35 chemicals

(3,4-Dimethoxy-phenyl)-[4-(furan-2-carbonyl)-piperazin-1-yl]-methanone chemical structure, C18H20N2O5, CAS 333757-31-6
(3,4-Dimethoxy-phenyl)-[4-(furan-2-carbonyl)-piperazin-1-yl]-methanone
CAS 333757-31-6C18H20N2O5
1-(2-Fluorobenzoyl)-4-(2-furoyl)piperazine chemical structure, C16H15FN2O3, CAS 332851-20-4
1-(2-Fluorobenzoyl)-4-(2-furoyl)piperazine
CAS 332851-20-4C16H15FN2O3
1-(3,5-Dimethoxybenzoyl)-4-(2-furoyl)piperazine chemical structure, C18H20N2O5, CAS 423745-34-0
1-(3,5-Dimethoxybenzoyl)-4-(2-furoyl)piperazine
CAS 423745-34-0C18H20N2O5
1-(2-Furoyl)-4-(3-methoxybenzoyl)piperazine chemical structure, C17H18N2O4, CAS 332897-85-5
1-(2-Furoyl)-4-(3-methoxybenzoyl)piperazine
CAS 332897-85-5C17H18N2O4
(3-Chlorophenyl)-[4-(furan-2-carbonyl)piperazin-1-yl]methanone chemical structure, C16H15ClN2O3, CAS 423733-09-9
(3-Chlorophenyl)-[4-(furan-2-carbonyl)piperazin-1-yl]methanone
CAS 423733-09-9C16H15ClN2O3
1-(3-Fluorobenzoyl)-4-(2-furoyl)piperazine chemical structure, C16H15FN2O3, CAS 332851-11-3
1-(3-Fluorobenzoyl)-4-(2-furoyl)piperazine
CAS 332851-11-3C16H15FN2O3
2,6-Difluorophenyl 4-(2-furylcarbonyl)piperazinyl ketone chemical structure, C16H14F2N2O3, CAS 496054-74-1
2,6-Difluorophenyl 4-(2-furylcarbonyl)piperazinyl ketone
CAS 496054-74-1C16H14F2N2O3
1-(4-Chlorobenzoyl)-4-(2-furoyl)piperazine chemical structure, C16H15ClN2O3, CAS 304878-52-2
1-(4-Chlorobenzoyl)-4-(2-furoyl)piperazine
CAS 304878-52-2C16H15ClN2O3
[4-(Furan-2-carbonyl)piperazin-1-yl]-(2-nitrophenyl)methanone chemical structure, C16H15N3O5, CAS 515872-73-8
[4-(Furan-2-carbonyl)piperazin-1-yl]-(2-nitrophenyl)methanone
CAS 515872-73-8C16H15N3O5
[4-(Furan-2-carbonyl)piperazin-1-yl]-(4-nitrophenyl)methanone chemical structure, C16H15N3O5, CAS 363591-04-2
[4-(Furan-2-carbonyl)piperazin-1-yl]-(4-nitrophenyl)methanone
CAS 363591-04-2C16H15N3O5
1-(Furan-2-carbonyl)-4-(3-nitrobenzoyl)piperazine chemical structure, C16H15N3O5, CAS 713095-97-7
1-(Furan-2-carbonyl)-4-(3-nitrobenzoyl)piperazine
CAS 713095-97-7C16H15N3O5
[4-(Furan-2-carbonyl)piperazin-1-yl]-(3-methyl-4-nitrophenyl)methanone chemical structure, C17H17N3O5, CAS 710976-40-2
[4-(Furan-2-carbonyl)piperazin-1-yl]-(3-methyl-4-nitrophenyl)methanone
CAS 710976-40-2C17H17N3O5
N-[4-[4-(Furan-2-carbonyl)piperazine-1-carbonyl]phenyl]acetamide chemical structure, C18H19N3O4, CAS 710976-65-1
N-[4-[4-(Furan-2-carbonyl)piperazine-1-carbonyl]phenyl]acetamide
CAS 710976-65-1C18H19N3O4
2-Furyl 4-[(4-methylphenyl)carbonyl]piperazinyl ketone chemical structure, C17H18N2O3, CAS 694473-64-8
2-Furyl 4-[(4-methylphenyl)carbonyl]piperazinyl ketone
CAS 694473-64-8C17H18N2O3
2-[4-(Furan-2-carbonyl)piperazine-1-carbonyl]-3-nitrobenzoic acid chemical structure, C17H15N3O7, CAS 293324-72-8
2-[4-(Furan-2-carbonyl)piperazine-1-carbonyl]-3-nitrobenzoic acid
CAS 293324-72-8C17H15N3O7
Furan-2-yl-[4-(3,4,5-trimethoxybenzoyl)piperazin-1-yl]methanone chemical structure, C19H22N2O6, CAS 293765-28-3
Furan-2-yl-[4-(3,4,5-trimethoxybenzoyl)piperazin-1-yl]methanone
CAS 293765-28-3C19H22N2O6
[4-(5-Chloro-2-methoxybenzoyl)piperazin-1-yl]-(furan-2-yl)methanone chemical structure, C17H17ClN2O4, CAS 710978-93-1
[4-(5-Chloro-2-methoxybenzoyl)piperazin-1-yl]-(furan-2-yl)methanone
CAS 710978-93-1C17H17ClN2O4
(2-Chlorophenyl)[4-(furan-2-ylcarbonyl)piperazin-1-yl]methanone chemical structure, C16H15ClN2O3, CAS 710973-67-4
(2-Chlorophenyl)[4-(furan-2-ylcarbonyl)piperazin-1-yl]methanone
CAS 710973-67-4C16H15ClN2O3
[4-(Furan-2-carbonyl)piperazin-1-yl]-(4-methoxy-3-nitrophenyl)methanone chemical structure, C17H17N3O6, CAS 710976-30-0
[4-(Furan-2-carbonyl)piperazin-1-yl]-(4-methoxy-3-nitrophenyl)methanone
CAS 710976-30-0C17H17N3O6
(4-(2,4-Dichlorobenzoyl)piperazin-1-yl)(furan-2-yl)methanone chemical structure, C16H14Cl2N2O3, CAS 831205-42-6
(4-(2,4-Dichlorobenzoyl)piperazin-1-yl)(furan-2-yl)methanone
CAS 831205-42-6C16H14Cl2N2O3
(4-(3,5-Dinitrobenzoyl)piperazin-1-yl)(furan-2-yl)methanone chemical structure, C16H14N4O7, CAS 487018-63-3
(4-(3,5-Dinitrobenzoyl)piperazin-1-yl)(furan-2-yl)methanone
CAS 487018-63-3C16H14N4O7
(4-(Furan-2-carbonyl)piperazin-1-yl)(2-methyl-3-nitrophenyl)methanone chemical structure, C17H17N3O5, CAS 825598-07-0
(4-(Furan-2-carbonyl)piperazin-1-yl)(2-methyl-3-nitrophenyl)methanone
CAS 825598-07-0C17H17N3O5
[4-(4,5-Dimethoxy-2-nitrobenzoyl)piperazin-1-yl]-(furan-2-yl)methanone chemical structure, C18H19N3O7, CAS 825598-41-2
[4-(4,5-Dimethoxy-2-nitrobenzoyl)piperazin-1-yl]-(furan-2-yl)methanone
CAS 825598-41-2C18H19N3O7
1-(3-Bromobenzoyl)-4-(2-furoyl)piperazine chemical structure, C16H15BrN2O3, CAS 881597-41-7
1-(3-Bromobenzoyl)-4-(2-furoyl)piperazine
CAS 881597-41-7C16H15BrN2O3