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Murcko scaffold

Piperazine, 1-benzoyl-4-(2-thienylcarbonyl)- scaffold

13 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
13
With full pages
5
Scaffold SMILES

O=C(c1ccccc1)N1CCN(C(=O)c2cccs2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Piperazine, 1-benzoyl-4-(2-thienylcarbonyl)- page
Murcko scaffold O=C(c1ccccc1)N1CCN(C(=O)c2cccs2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

(2-Fluorophenyl)-[4-(thiophene-2-carbonyl)piperazin-1-yl]methanone chemical structure, C16H15FN2O2S, CAS 423752-45-8
(2-Fluorophenyl)-[4-(thiophene-2-carbonyl)piperazin-1-yl]methanone
CAS 423752-45-8C16H15FN2O2S
(3-Methoxyphenyl)-[4-(thiophene-2-carbonyl)piperazin-1-yl]methanone chemical structure, C17H18N2O3S, CAS 333756-08-4
(3-Methoxyphenyl)-[4-(thiophene-2-carbonyl)piperazin-1-yl]methanone
CAS 333756-08-4C17H18N2O3S
(3-Fluorophenyl)[4-(thiophen-2-ylcarbonyl)piperazin-1-yl]methanone chemical structure, C16H15FN2O2S, CAS 5967-47-5
(3-Fluorophenyl)[4-(thiophen-2-ylcarbonyl)piperazin-1-yl]methanone
CAS 5967-47-5C16H15FN2O2S
(2-Methoxyphenyl)-[4-(thiophene-2-carbonyl)piperazin-1-yl]methanone chemical structure, C17H18N2O3S, CAS 333756-56-2
(2-Methoxyphenyl)-[4-(thiophene-2-carbonyl)piperazin-1-yl]methanone
CAS 333756-56-2C17H18N2O3S
Piperazine, 1-benzoyl-4-(2-thienylcarbonyl)- chemical structure, C16H16N2O2S, CAS 333757-03-2
Piperazine, 1-benzoyl-4-(2-thienylcarbonyl)-
CAS 333757-03-2C16H16N2O2S
(4-Fluorophenyl)-[4-(thiophene-2-carbonyl)piperazin-1-yl]methanone chemical structure, C16H15FN2O2S, CAS 333757-28-1
(4-Fluorophenyl)-[4-(thiophene-2-carbonyl)piperazin-1-yl]methanone
CAS 333757-28-1C16H15FN2O2S
(4-Methoxyphenyl)-[4-(thiophene-2-carbonyl)piperazin-1-yl]methanone chemical structure, C17H18N2O3S, CAS 333757-78-1
(4-Methoxyphenyl)-[4-(thiophene-2-carbonyl)piperazin-1-yl]methanone
CAS 333757-78-1C17H18N2O3S
(3-Chlorophenyl)-[4-(thiophene-2-carbonyl)piperazin-1-yl]methanone chemical structure, C16H15ClN2O2S, CAS 333757-83-8
(3-Chlorophenyl)-[4-(thiophene-2-carbonyl)piperazin-1-yl]methanone
CAS 333757-83-8C16H15ClN2O2S
(4-Nitrophenyl)-[4-(thiophene-2-carbonyl)piperazin-1-yl]methanone chemical structure, C16H15N3O4S, CAS 333756-02-8
(4-Nitrophenyl)-[4-(thiophene-2-carbonyl)piperazin-1-yl]methanone
CAS 333756-02-8C16H15N3O4S
[4-(3,5-Dimethoxybenzoyl)piperazin-1-yl]-thiophen-2-ylmethanone chemical structure, C18H20N2O4S, CAS 489464-84-8
[4-(3,5-Dimethoxybenzoyl)piperazin-1-yl]-thiophen-2-ylmethanone
CAS 489464-84-8C18H20N2O4S
(3,4-Dimethoxy-phenyl)-[4-(thiophene-2-carbonyl)-piperazin-1-yl]-methanone chemical structure, C18H20N2O4S, CAS 333756-53-9
(3,4-Dimethoxy-phenyl)-[4-(thiophene-2-carbonyl)-piperazin-1-yl]-methanone
CAS 333756-53-9C18H20N2O4S
[4-(Thiophene-2-carbonyl)-piperazin-1-yl]-(3,4,5-trimethoxy-phenyl)-methanone chemical structure, C19H22N2O5S, CAS 333757-64-5
[4-(Thiophene-2-carbonyl)-piperazin-1-yl]-(3,4,5-trimethoxy-phenyl)-methanone
CAS 333757-64-5C19H22N2O5S
1-(2,3-Dimethoxybenzoyl)-4-(2-thienylcarbonyl)piperazine chemical structure, C18H20N2O4S, CAS 333757-71-4
1-(2,3-Dimethoxybenzoyl)-4-(2-thienylcarbonyl)piperazine
CAS 333757-71-4C18H20N2O4S