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Murcko scaffold

1-Benzyl-4-(thiophene-2-sulfonyl)-piperazine scaffold

11 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
11
With full pages
4
Scaffold SMILES

O=S(=O)(c1cccs1)N1CCN(Cc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Benzyl-4-(thiophene-2-sulfonyl)-piperazine page
Murcko scaffold O=S(=O)(c1cccs1)N1CCN(Cc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

1-Benzyl-4-(thiophene-2-sulfonyl)-piperazine chemical structure, C15H18N2O2S2, CAS 324779-81-9
1-Benzyl-4-(thiophene-2-sulfonyl)-piperazine
CAS 324779-81-9C15H18N2O2S2
5-Methyl-2-{[4-benzylpiperazinyl]sulfonyl}thiophene chemical structure, C16H20N2O2S2, CAS 620104-14-5
5-Methyl-2-{[4-benzylpiperazinyl]sulfonyl}thiophene
CAS 620104-14-5C16H20N2O2S2
1-[(4-Fluorophenyl)methyl]-4-thiophen-2-ylsulfonylpiperazine chemical structure, C15H17FN2O2S2, CAS 827592-58-5
1-[(4-Fluorophenyl)methyl]-4-thiophen-2-ylsulfonylpiperazine
CAS 827592-58-5C15H17FN2O2S2
1-[(3,4-Dichlorophenyl)methyl]-4-thiophen-2-ylsulfonylpiperazine chemical structure, C15H16Cl2N2O2S2, CAS 827592-35-8
1-[(3,4-Dichlorophenyl)methyl]-4-thiophen-2-ylsulfonylpiperazine
CAS 827592-35-8C15H16Cl2N2O2S2
1-[(2,4-Dichlorophenyl)methyl]-4-thiophen-2-ylsulfonylpiperazine chemical structure, C15H16Cl2N2O2S2, CAS 827592-42-7
1-[(2,4-Dichlorophenyl)methyl]-4-thiophen-2-ylsulfonylpiperazine
CAS 827592-42-7C15H16Cl2N2O2S2
1-[(3-Fluorophenyl)methyl]-4-thiophen-2-ylsulfonylpiperazine chemical structure, C15H17FN2O2S2, CAS 827592-91-6
1-[(3-Fluorophenyl)methyl]-4-thiophen-2-ylsulfonylpiperazine
CAS 827592-91-6C15H17FN2O2S2
1-[(2-Chloro-4-fluorophenyl)methyl]-4-thiophen-2-ylsulfonylpiperazine chemical structure, C15H16ClFN2O2S2, CAS 827592-95-0
1-[(2-Chloro-4-fluorophenyl)methyl]-4-thiophen-2-ylsulfonylpiperazine
CAS 827592-95-0C15H16ClFN2O2S2
1-(5-Chlorothiophen-2-yl)sulfonyl-4-[(2,5-dimethoxyphenyl)methyl]piperazine chemical structure, C17H21ClN2O4S2, CAS 867310-88-1
1-(5-Chlorothiophen-2-yl)sulfonyl-4-[(2,5-dimethoxyphenyl)methyl]piperazine
CAS 867310-88-1C17H21ClN2O4S2
1-[(5-Chlorothiophen-2-yl)sulfonyl]-4-(3-methoxybenzyl)piperazine chemical structure, C16H19ClN2O3S2, CAS 900596-21-6
1-[(5-Chlorothiophen-2-yl)sulfonyl]-4-(3-methoxybenzyl)piperazine
CAS 900596-21-6C16H19ClN2O3S2
2-({4-[(3-Bromophenyl)methyl]piperazinyl}sulfonyl)-5-chlorothiophene chemical structure, C15H16BrClN2O2S2, CAS 886632-49-1
2-({4-[(3-Bromophenyl)methyl]piperazinyl}sulfonyl)-5-chlorothiophene
CAS 886632-49-1C15H16BrClN2O2S2
1-Benzyl-4-[(5-fluoro-2-thienyl)sulfonyl]piperazine chemical structure, C15H17FN2O2S2, CAS 1855891-06-3
1-Benzyl-4-[(5-fluoro-2-thienyl)sulfonyl]piperazine
CAS 1855891-06-3C15H17FN2O2S2