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Murcko scaffold

[4-(Benzenesulfonyl)piperazin-1-yl]-thiophen-2-ylmethanone scaffold

11 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
11
With full pages
9
Scaffold SMILES

O=C(c1cccs1)N1CCN(S(=O)(=O)c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the [4-(Benzenesulfonyl)piperazin-1-yl]-thiophen-2-ylmethanone page
Murcko scaffold O=C(c1cccs1)N1CCN(S(=O)(=O)c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

[4-(Benzenesulfonyl)piperazin-1-yl]-thiophen-2-ylmethanone chemical structure, C15H16N2O3S2, CAS 333757-63-4
[4-(Benzenesulfonyl)piperazin-1-yl]-thiophen-2-ylmethanone
CAS 333757-63-4C15H16N2O3S2
4-[(4-Fluorophenyl)sulfonyl]piperazinyl 2-thienyl ketone chemical structure, C15H15FN2O3S2, CAS 428822-90-6
4-[(4-Fluorophenyl)sulfonyl]piperazinyl 2-thienyl ketone
CAS 428822-90-6C15H15FN2O3S2
(4-((4-Chlorophenyl)sulfonyl)piperazin-1-yl)(thiophen-2-yl)methanone chemical structure, C15H15ClN2O3S2, CAS 333756-64-2
(4-((4-Chlorophenyl)sulfonyl)piperazin-1-yl)(thiophen-2-yl)methanone
CAS 333756-64-2C15H15ClN2O3S2
[4-(4-Methoxy-benzenesulfonyl)-piperazin-1-yl]-thiophen-2-yl-methanone chemical structure, C16H18N2O4S2, CAS 333756-92-6
[4-(4-Methoxy-benzenesulfonyl)-piperazin-1-yl]-thiophen-2-yl-methanone
CAS 333756-92-6C16H18N2O4S2
Thiophen-2-yl-[4-(toluene-4-sulfonyl)-piperazin-1-yl]-methanone chemical structure, C16H18N2O3S2, CAS 333757-73-6
Thiophen-2-yl-[4-(toluene-4-sulfonyl)-piperazin-1-yl]-methanone
CAS 333757-73-6C16H18N2O3S2
[4-(4-Nitrophenyl)sulfonylpiperazin-1-yl]-thiophen-2-ylmethanone chemical structure, C15H15N3O5S2, CAS 500277-92-9
[4-(4-Nitrophenyl)sulfonylpiperazin-1-yl]-thiophen-2-ylmethanone
CAS 500277-92-9C15H15N3O5S2
N-[4-[4-(Thiophene-2-carbonyl)piperazin-1-yl]sulfonylphenyl]acetamide chemical structure, C17H19N3O4S2, CAS 461400-09-9
N-[4-[4-(Thiophene-2-carbonyl)piperazin-1-yl]sulfonylphenyl]acetamide
CAS 461400-09-9C17H19N3O4S2
(4-(Mesitylsulfonyl)piperazin-1-yl)(thiophen-2-yl)methanone chemical structure, C18H22N2O3S2, CAS 692761-98-1
(4-(Mesitylsulfonyl)piperazin-1-yl)(thiophen-2-yl)methanone
CAS 692761-98-1C18H22N2O3S2
[4-(Benzenesulfonyl)piperazin-1-yl]-(5-chlorothiophen-2-yl)methanone chemical structure, C15H15ClN2O3S2, CAS 588687-83-6
[4-(Benzenesulfonyl)piperazin-1-yl]-(5-chlorothiophen-2-yl)methanone
CAS 588687-83-6C15H15ClN2O3S2
[4-(3,4-Dimethoxyphenyl)sulfonylpiperazin-1-yl]-thiophen-2-ylmethanone chemical structure, C17H20N2O5S2, CAS 717870-97-8
[4-(3,4-Dimethoxyphenyl)sulfonylpiperazin-1-yl]-thiophen-2-ylmethanone
CAS 717870-97-8C17H20N2O5S2
[4-(4-Chlorophenyl)sulfonylpiperazin-1-yl]-(5-chlorothiophen-2-yl)methanone chemical structure, C15H14Cl2N2O3S2, CAS 924160-28-1
[4-(4-Chlorophenyl)sulfonylpiperazin-1-yl]-(5-chlorothiophen-2-yl)methanone
CAS 924160-28-1C15H14Cl2N2O3S2