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Murcko scaffold

Ring system with 3 rings and 21 atoms

234 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
234
With full pages
66
Scaffold SMILES

O=C(CSc1nc2sccc2c(=O)[nH]1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nc2sccc2c(=O)[nH]1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 234 chemicals

2-[(5,6-Dimethyl-4-oxo-3H-thieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-phenylacetamide chemical structure, C16H15N3O2S2, CAS 276255-48-2
2-[(5,6-Dimethyl-4-oxo-3H-thieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-phenylacetamide
CAS 276255-48-2C16H15N3O2S2
2-(5,6-Dimethyl-4-oxo-3-prop-2-enylthieno[2,3-d]pyrimidin-2-yl)sulfanyl-N-(4-methylphenyl)acetamide chemical structure, C20H21N3O2S2, CAS 314260-49-6
2-(5,6-Dimethyl-4-oxo-3-prop-2-enylthieno[2,3-d]pyrimidin-2-yl)sulfanyl-N-(4-methylphenyl)acetamide
CAS 314260-49-6C20H21N3O2S2
2-[(3-Allyl-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio]-N-phenylacetamide chemical structure, C19H19N3O2S2, CAS 315685-47-3
2-[(3-Allyl-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio]-N-phenylacetamide
CAS 315685-47-3C19H19N3O2S2
2-[(3-Allyl-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio]-N-(4-ethoxyphenyl)acetamide chemical structure, C21H23N3O3S2, CAS 315685-48-4
2-[(3-Allyl-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio]-N-(4-ethoxyphenyl)acetamide
CAS 315685-48-4C21H23N3O3S2
N-(2,6-Dichlorophenyl)-2-(5,6-dimethyl-4-oxo-3-prop-2-enylthieno[2,3-d]pyrimidin-2-yl)sulfanylacetamide chemical structure, C19H17Cl2N3O2S2, CAS 379256-76-5
N-(2,6-Dichlorophenyl)-2-(5,6-dimethyl-4-oxo-3-prop-2-enylthieno[2,3-d]pyrimidin-2-yl)sulfanylacetamide
CAS 379256-76-5C19H17Cl2N3O2S2
2-((3-Allyl-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)-N-(4-methoxyphenyl)acetamide chemical structure, C20H21N3O3S2, CAS 421578-01-0
2-((3-Allyl-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)-N-(4-methoxyphenyl)acetamide
CAS 421578-01-0C20H21N3O3S2
N-(3,5-Dimethylphenyl)-2-(6-methyl-4-oxo-3-prop-2-enylthieno[2,3-d]pyrimidin-2-yl)sulfanylacetamide chemical structure, C20H21N3O2S2, CAS 701228-29-7
N-(3,5-Dimethylphenyl)-2-(6-methyl-4-oxo-3-prop-2-enylthieno[2,3-d]pyrimidin-2-yl)sulfanylacetamide
CAS 701228-29-7C20H21N3O2S2
N-(2,5-Dimethoxyphenyl)-2-(6-methyl-4-oxo-3-prop-2-enylthieno[2,3-d]pyrimidin-2-yl)sulfanylacetamide chemical structure, C20H21N3O4S2, CAS 701238-47-3
N-(2,5-Dimethoxyphenyl)-2-(6-methyl-4-oxo-3-prop-2-enylthieno[2,3-d]pyrimidin-2-yl)sulfanylacetamide
CAS 701238-47-3C20H21N3O4S2
2-[(3-Allyl-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio]-N-(2,5-dichlorophenyl)acetamide chemical structure, C19H17Cl2N3O2S2, CAS 678538-27-7
2-[(3-Allyl-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio]-N-(2,5-dichlorophenyl)acetamide
CAS 678538-27-7C19H17Cl2N3O2S2
N-(2,5-Dichlorophenyl)-2-(6-ethyl-4-oxo-3-prop-2-enylthieno[2,3-d]pyrimidin-2-yl)sulfanylacetamide chemical structure, C19H17Cl2N3O2S2, CAS 702649-37-4
N-(2,5-Dichlorophenyl)-2-(6-ethyl-4-oxo-3-prop-2-enylthieno[2,3-d]pyrimidin-2-yl)sulfanylacetamide
CAS 702649-37-4C19H17Cl2N3O2S2
N-(2,3-Dichlorophenyl)-2-(6-ethyl-4-oxo-3-prop-2-enylthieno[2,3-d]pyrimidin-2-yl)sulfanylacetamide chemical structure, C19H17Cl2N3O2S2, CAS 701244-76-0
N-(2,3-Dichlorophenyl)-2-(6-ethyl-4-oxo-3-prop-2-enylthieno[2,3-d]pyrimidin-2-yl)sulfanylacetamide
CAS 701244-76-0C19H17Cl2N3O2S2
N-(3-Chloro-2-methylphenyl)-2-((3-ethyl-5,6-dimethyl-4-oxo-3,4-dihydrothieno(2,3-D)pyrimidin-2-yl)sulfanyl)acetamide chemical structure, C19H20ClN3O2S2, CAS 335399-64-9
N-(3-Chloro-2-methylphenyl)-2-((3-ethyl-5,6-dimethyl-4-oxo-3,4-dihydrothieno(2,3-D)pyrimidin-2-yl)sulfanyl)acetamide
CAS 335399-64-9C19H20ClN3O2S2
N-(4-Ethoxyphenyl)-2-(3,5,6-trimethyl-4-oxo(3-hydrothiopheno[2,3-d]pyrimidin-2-ylthio))acetamide chemical structure, C19H21N3O3S2, CAS 333406-27-2
N-(4-Ethoxyphenyl)-2-(3,5,6-trimethyl-4-oxo(3-hydrothiopheno[2,3-d]pyrimidin-2-ylthio))acetamide
CAS 333406-27-2C19H21N3O3S2
Ethyl 3-(2-((3,5,6-trimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetamido)benzoate chemical structure, C20H21N3O4S2, CAS 333406-78-3
Ethyl 3-(2-((3,5,6-trimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetamido)benzoate
CAS 333406-78-3C20H21N3O4S2
2-(5,6-Dimethyl-4-oxo-3-prop-2-enyl(3-hydrothiopheno[2,3-d]pyrimidin-2-ylthio))-N-(2,5-dimethylphenyl)acetamide chemical structure, C21H23N3O2S2, CAS 510724-72-8
2-(5,6-Dimethyl-4-oxo-3-prop-2-enyl(3-hydrothiopheno[2,3-d]pyrimidin-2-ylthio))-N-(2,5-dimethylphenyl)acetamide
CAS 510724-72-8C21H23N3O2S2
2-{[5,6-Dimethyl-4-oxo-3-(prop-2-en-1-yl)-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N-(4-methoxyphenyl)acetamide chemical structure, C20H21N3O3S2, CAS 510724-73-9
2-{[5,6-Dimethyl-4-oxo-3-(prop-2-en-1-yl)-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N-(4-methoxyphenyl)acetamide
CAS 510724-73-9C20H21N3O3S2
2-{[5,6-Dimethyl-4-oxo-3-(prop-2-en-1-yl)-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N-(3-methoxyphenyl)acetamide chemical structure, C20H21N3O3S2, CAS 510724-74-0
2-{[5,6-Dimethyl-4-oxo-3-(prop-2-en-1-yl)-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N-(3-methoxyphenyl)acetamide
CAS 510724-74-0C20H21N3O3S2
2-{[5,6-Dimethyl-4-oxo-3-(prop-2-en-1-yl)-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N-(2-methoxyphenyl)acetamide chemical structure, C20H21N3O3S2, CAS 510724-75-1
2-{[5,6-Dimethyl-4-oxo-3-(prop-2-en-1-yl)-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N-(2-methoxyphenyl)acetamide
CAS 510724-75-1C20H21N3O3S2
2-{[5,6-Dimethyl-4-oxo-3-(prop-2-en-1-yl)-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N-(4-fluorophenyl)acetamide chemical structure, C19H18FN3O2S2, CAS 510724-76-2
2-{[5,6-Dimethyl-4-oxo-3-(prop-2-en-1-yl)-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N-(4-fluorophenyl)acetamide
CAS 510724-76-2C19H18FN3O2S2
2-{[5,6-Dimethyl-4-oxo-3-(prop-2-en-1-yl)-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N-(3-fluorophenyl)acetamide chemical structure, C19H18FN3O2S2, CAS 510724-77-3
2-{[5,6-Dimethyl-4-oxo-3-(prop-2-en-1-yl)-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N-(3-fluorophenyl)acetamide
CAS 510724-77-3C19H18FN3O2S2
2-{[5,6-Dimethyl-4-oxo-3-(prop-2-en-1-yl)-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N-(2-fluorophenyl)acetamide chemical structure, C19H18FN3O2S2, CAS 510724-78-4
2-{[5,6-Dimethyl-4-oxo-3-(prop-2-en-1-yl)-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N-(2-fluorophenyl)acetamide
CAS 510724-78-4C19H18FN3O2S2
N-(4-Chlorophenyl)-2-{[5,6-dimethyl-4-oxo-3-(prop-2-en-1-yl)-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]sulfanyl}acetamide chemical structure, C19H18ClN3O2S2, CAS 510724-79-5
N-(4-Chlorophenyl)-2-{[5,6-dimethyl-4-oxo-3-(prop-2-en-1-yl)-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]sulfanyl}acetamide
CAS 510724-79-5C19H18ClN3O2S2
N-[4-(Dimethylamino)phenyl]-2-[(4-hydroxy-5,6-dimethylthieno[2,3-d]pyrimidin-2-yl)sulfanyl]acetamide chemical structure, C18H20N4O2S2, CAS 511237-59-5
N-[4-(Dimethylamino)phenyl]-2-[(4-hydroxy-5,6-dimethylthieno[2,3-d]pyrimidin-2-yl)sulfanyl]acetamide
CAS 511237-59-5C18H20N4O2S2
N-(4-Methoxyphenyl)-2-(3,5,6-trimethyl-4-oxo(3-hydrothiopheno[2,3-d]pyrimidin-2-ylthio))acetamide chemical structure, C18H19N3O3S2, CAS 333406-16-9
N-(4-Methoxyphenyl)-2-(3,5,6-trimethyl-4-oxo(3-hydrothiopheno[2,3-d]pyrimidin-2-ylthio))acetamide
CAS 333406-16-9C18H19N3O3S2