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Murcko scaffold

Ring system with 3 rings and 20 atoms

82 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
82
With full pages
5
Scaffold SMILES

O=c1cccc(-c2ccccc2)n1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1cccc(-c2ccccc2)n1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 82 chemicals

Methyl 4-{[2-oxo-6-phenyl-1(2H)-pyridinyl]methyl}benzenecarboxylate chemical structure, C20H17NO3, CAS 400076-10-0
Methyl 4-{[2-oxo-6-phenyl-1(2H)-pyridinyl]methyl}benzenecarboxylate
CAS 400076-10-0C20H17NO3
1-(4-Chlorobenzyl)-6-phenyl-2(1H)-pyridinone chemical structure, C18H14ClNO, CAS 303145-29-1
1-(4-Chlorobenzyl)-6-phenyl-2(1H)-pyridinone
CAS 303145-29-1C18H14ClNO
1-(4-Chlorobenzyl)-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C20H15ClN2OS, CAS 478042-79-4
1-(4-Chlorobenzyl)-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 478042-79-4C20H15ClN2OS
1-Benzyl-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C20H16N2OS, CAS 478042-80-7
1-Benzyl-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 478042-80-7C20H16N2OS
1-(4-Methylbenzyl)-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C21H18N2OS, CAS 478042-81-8
1-(4-Methylbenzyl)-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 478042-81-8C21H18N2OS
6-(4-Chlorophenyl)-1-(4-fluorobenzyl)-4-(methylsulfanyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C20H14ClFN2OS, CAS 478042-87-4
6-(4-Chlorophenyl)-1-(4-fluorobenzyl)-4-(methylsulfanyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 478042-87-4C20H14ClFN2OS
6-(4-Chlorophenyl)-1-(4-methylbenzyl)-4-(methylsulfanyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C21H17ClN2OS, CAS 478042-91-0
6-(4-Chlorophenyl)-1-(4-methylbenzyl)-4-(methylsulfanyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 478042-91-0C21H17ClN2OS
6-(4-Chlorophenyl)-1-(2-methylbenzyl)-4-(methylsulfanyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C21H17ClN2OS, CAS 478042-92-1
6-(4-Chlorophenyl)-1-(2-methylbenzyl)-4-(methylsulfanyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 478042-92-1C21H17ClN2OS
1-Benzyl-6-(4-chlorophenyl)-4-(methylsulfanyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C20H15ClN2OS, CAS 478042-93-2
1-Benzyl-6-(4-chlorophenyl)-4-(methylsulfanyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 478042-93-2C20H15ClN2OS
1-(3-Fluorobenzyl)-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C20H15FN2OS, CAS 478042-99-8
1-(3-Fluorobenzyl)-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 478042-99-8C20H15FN2OS
1-(2-Chlorobenzyl)-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C20H15ClN2OS, CAS 478043-00-4
1-(2-Chlorobenzyl)-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 478043-00-4C20H15ClN2OS
1-(3-Methylbenzyl)-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C21H18N2OS, CAS 478043-01-5
1-(3-Methylbenzyl)-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 478043-01-5C21H18N2OS
6-(4-Chlorophenyl)-1-(3,4-dichlorobenzyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C19H11Cl3N2O, CAS 339108-77-9
6-(4-Chlorophenyl)-1-(3,4-dichlorobenzyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 339108-77-9C19H11Cl3N2O
1-(3,4-Dichlorobenzyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C19H12Cl2N2O, CAS 339108-80-4
1-(3,4-Dichlorobenzyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 339108-80-4C19H12Cl2N2O
1-(4-Methylbenzyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C20H16N2O, CAS 339108-83-7
1-(4-Methylbenzyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 339108-83-7C20H16N2O
1-(2,6-Dichlorobenzyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C19H12Cl2N2O, CAS 339108-86-0
1-(2,6-Dichlorobenzyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 339108-86-0C19H12Cl2N2O
1-[(2-Chlorophenyl)methyl]-2-oxo-6-phenylpyridine-3-carbonitrile chemical structure, C19H13ClN2O, CAS 339108-92-8
1-[(2-Chlorophenyl)methyl]-2-oxo-6-phenylpyridine-3-carbonitrile
CAS 339108-92-8C19H13ClN2O
1-(3-Chlorobenzyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C19H13ClN2O, CAS 339108-94-0
1-(3-Chlorobenzyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 339108-94-0C19H13ClN2O
1-(4-Chlorobenzyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C19H13ClN2O, CAS 339108-97-3
1-(4-Chlorobenzyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 339108-97-3C19H13ClN2O
1-(4-Methoxybenzyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C20H16N2O2, CAS 339109-00-1
1-(4-Methoxybenzyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 339109-00-1C20H16N2O2
2-Oxo-6-phenyl-1-[3-(trifluoromethyl)benzyl]-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C20H13F3N2O, CAS 339109-03-4
2-Oxo-6-phenyl-1-[3-(trifluoromethyl)benzyl]-1,2-dihydro-3-pyridinecarbonitrile
CAS 339109-03-4C20H13F3N2O
1-[4-(tert-Butyl)benzyl]-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C23H22N2O, CAS 339109-06-7
1-[4-(tert-Butyl)benzyl]-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 339109-06-7C23H22N2O
1-(3-Chlorobenzyl)-6-(4-chlorophenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C19H12Cl2N2O, CAS 339109-55-6
1-(3-Chlorobenzyl)-6-(4-chlorophenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 339109-55-6C19H12Cl2N2O
6-(4-Chlorophenyl)-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C20H12ClF3N2O, CAS 339109-58-9
6-(4-Chlorophenyl)-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-3-pyridinecarbonitrile
CAS 339109-58-9C20H12ClF3N2O