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Murcko scaffold

Ring system with 3 rings and 21 atoms

60 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
60
With full pages
4
Scaffold SMILES

O=C1NCC(C(=O)c2ccccc2)C(c2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NCC(C(=O)c2ccccc2)C(c2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 60 chemicals

6-(3-Ethoxy-4-hydroxy-phenyl)-4-hydroxy-5-(4-methoxy-benzoyl)-4-trifluoromethyl-tetrahydro-pyrimidin-2-one chemical structure, C21H21F3N2O6, CAS 1005054-35-2
6-(3-Ethoxy-4-hydroxy-phenyl)-4-hydroxy-5-(4-methoxy-benzoyl)-4-trifluoromethyl-tetrahydro-pyrimidin-2-one
CAS 1005054-35-2C21H21F3N2O6
5-(4-Fluorobenzoyl)tetrahydro-4-hydroxy-6-(4-methoxyphenyl)-4-(trifluoromethyl)-2(1H)-pyrimidinone chemical structure, C19H16F4N2O4, CAS 1005068-68-7
5-(4-Fluorobenzoyl)tetrahydro-4-hydroxy-6-(4-methoxyphenyl)-4-(trifluoromethyl)-2(1H)-pyrimidinone
CAS 1005068-68-7C19H16F4N2O4
5-(4-Bromobenzoyl)-4-hydroxy-6-(4-methoxyphenyl)-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one chemical structure, C19H16BrF3N2O4, CAS 473566-96-0
5-(4-Bromobenzoyl)-4-hydroxy-6-(4-methoxyphenyl)-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one
CAS 473566-96-0C19H16BrF3N2O4
5-Benzoyl-4-hydroxy-6-(4-hydroxyphenyl)-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one chemical structure, C18H15F3N2O4, CAS 374561-32-7
5-Benzoyl-4-hydroxy-6-(4-hydroxyphenyl)-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one
CAS 374561-32-7C18H15F3N2O4
5-(4-Chlorobenzoyl)-4-hydroxy-6-(4-methylphenyl)-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C19H16ClF3N2O3, CAS 474005-17-9
5-(4-Chlorobenzoyl)-4-hydroxy-6-(4-methylphenyl)-4-(trifluoromethyl)-1,3-diazinan-2-one
CAS 474005-17-9C19H16ClF3N2O3
5-(4-Chlorobenzoyl)-6-(3-ethoxy-4-hydroxyphenyl)-4-hydroxy-4-(trifluoromethyl)tetrahydro-2(1H)-pyrimidinone chemical structure, C20H18ClF3N2O5, CAS 474005-43-1
5-(4-Chlorobenzoyl)-6-(3-ethoxy-4-hydroxyphenyl)-4-hydroxy-4-(trifluoromethyl)tetrahydro-2(1H)-pyrimidinone
CAS 474005-43-1C20H18ClF3N2O5
5-Benzoyl-6-(3,4-dichlorophenyl)-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one chemical structure, C18H13Cl2F3N2O3, CAS 474005-46-4
5-Benzoyl-6-(3,4-dichlorophenyl)-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one
CAS 474005-46-4C18H13Cl2F3N2O3
4-Hydroxy-5-(4-methylbenzoyl)-6-(4-methylphenyl)-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C20H19F3N2O3, CAS 474006-37-6
4-Hydroxy-5-(4-methylbenzoyl)-6-(4-methylphenyl)-4-(trifluoromethyl)-1,3-diazinan-2-one
CAS 474006-37-6C20H19F3N2O3
6-(3,4-Dimethoxyphenyl)-5-(4-fluorobenzoyl)-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one chemical structure, C20H18F4N2O5, CAS 474007-46-0
6-(3,4-Dimethoxyphenyl)-5-(4-fluorobenzoyl)-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one
CAS 474007-46-0C20H18F4N2O5
6-(4-Bromophenyl)-5-(4-chlorobenzoyl)-4-hydroxy-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C18H13BrClF3N2O3, CAS 474007-55-1
6-(4-Bromophenyl)-5-(4-chlorobenzoyl)-4-hydroxy-4-(trifluoromethyl)-1,3-diazinan-2-one
CAS 474007-55-1C18H13BrClF3N2O3
5-Benzoyl-6-(3-ethoxy-4-hydroxyphenyl)-4-hydroxy-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C20H19F3N2O5, CAS 474007-91-5
5-Benzoyl-6-(3-ethoxy-4-hydroxyphenyl)-4-hydroxy-4-(trifluoromethyl)-1,3-diazinan-2-one
CAS 474007-91-5C20H19F3N2O5
5-Benzoyl-4-hydroxy-6-(3-nitrophenyl)-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C18H14F3N3O5, CAS 376351-99-4
5-Benzoyl-4-hydroxy-6-(3-nitrophenyl)-4-(trifluoromethyl)-1,3-diazinan-2-one
CAS 376351-99-4C18H14F3N3O5
6-(4-Fluorophenyl)-4-hydroxy-5-(4-methylbenzoyl)-4-(trifluoromethyl)tetrahydro-2(1H)-pyrimidinone chemical structure, C19H16F4N2O3, CAS 474255-55-5
6-(4-Fluorophenyl)-4-hydroxy-5-(4-methylbenzoyl)-4-(trifluoromethyl)tetrahydro-2(1H)-pyrimidinone
CAS 474255-55-5C19H16F4N2O3
4-Hydroxy-6-(4-methoxyphenyl)-5-(4-methylbenzoyl)-4-(trifluoromethyl)tetrahydro-2(1H)-pyrimidinone chemical structure, C20H19F3N2O4, CAS 474302-68-6
4-Hydroxy-6-(4-methoxyphenyl)-5-(4-methylbenzoyl)-4-(trifluoromethyl)tetrahydro-2(1H)-pyrimidinone
CAS 474302-68-6C20H19F3N2O4
5-(4-Chlorobenzoyl)-6-(4-fluorophenyl)-4-hydroxy-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C18H13ClF4N2O3, CAS 474302-85-7
5-(4-Chlorobenzoyl)-6-(4-fluorophenyl)-4-hydroxy-4-(trifluoromethyl)-1,3-diazinan-2-one
CAS 474302-85-7C18H13ClF4N2O3
6-[4-(Allyloxy)phenyl]-5-(4-fluorobenzoyl)-4-hydroxy-4-(trifluoromethyl)tetrahydro-2(1H)-pyrimidinone chemical structure, C21H18F4N2O4, CAS 474303-03-2
6-[4-(Allyloxy)phenyl]-5-(4-fluorobenzoyl)-4-hydroxy-4-(trifluoromethyl)tetrahydro-2(1H)-pyrimidinone
CAS 474303-03-2C21H18F4N2O4
4-Hydroxy-5-(4-methylbenzoyl)-6-(3-nitrophenyl)-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C19H16F3N3O5, CAS 474260-47-4
4-Hydroxy-5-(4-methylbenzoyl)-6-(3-nitrophenyl)-4-(trifluoromethyl)-1,3-diazinan-2-one
CAS 474260-47-4C19H16F3N3O5
5-(4-Chlorobenzoyl)-6-(2-fluorophenyl)-4-hydroxy-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C18H13ClF4N2O3, CAS 474260-63-4
5-(4-Chlorobenzoyl)-6-(2-fluorophenyl)-4-hydroxy-4-(trifluoromethyl)-1,3-diazinan-2-one
CAS 474260-63-4C18H13ClF4N2O3
5-Benzoyl-6-[4-(dimethylamino)phenyl]-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one chemical structure, C20H20F3N3O3, CAS 459147-62-7
5-Benzoyl-6-[4-(dimethylamino)phenyl]-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one
CAS 459147-62-7C20H20F3N3O3
5-Benzoyl-6-(2,5-dimethoxyphenyl)-4-hydroxy-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C20H19F3N2O5, CAS 375347-98-1
5-Benzoyl-6-(2,5-dimethoxyphenyl)-4-hydroxy-4-(trifluoromethyl)-1,3-diazinan-2-one
CAS 375347-98-1C20H19F3N2O5
5-(4-Chlorobenzoyl)-6-(4-ethoxyphenyl)-4-hydroxy-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C20H18ClF3N2O4, CAS 1005122-89-3
5-(4-Chlorobenzoyl)-6-(4-ethoxyphenyl)-4-hydroxy-4-(trifluoromethyl)-1,3-diazinan-2-one
CAS 1005122-89-3C20H18ClF3N2O4
5-(4-Chlorobenzoyl)-4-hydroxy-6-(4-methoxyphenyl)-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C19H16ClF3N2O4, CAS 474006-16-1
5-(4-Chlorobenzoyl)-4-hydroxy-6-(4-methoxyphenyl)-4-(trifluoromethyl)-1,3-diazinan-2-one
CAS 474006-16-1C19H16ClF3N2O4
5-Benzoyl-4-hydroxy-6-(4-hydroxy-3-methoxyphenyl)-4-(trifluoromethyl)-1,3-diazinan-2-one chemical structure, C19H17F3N2O5, CAS 374561-29-2
5-Benzoyl-4-hydroxy-6-(4-hydroxy-3-methoxyphenyl)-4-(trifluoromethyl)-1,3-diazinan-2-one
CAS 374561-29-2C19H17F3N2O5
6-(3,4-Dimethoxyphenyl)-4-hydroxy-5-(4-methylbenzoyl)-4-(trifluoromethyl)tetrahydro-2(1H)-pyrimidinone chemical structure, C21H21F3N2O5, CAS 474004-82-5
6-(3,4-Dimethoxyphenyl)-4-hydroxy-5-(4-methylbenzoyl)-4-(trifluoromethyl)tetrahydro-2(1H)-pyrimidinone
CAS 474004-82-5C21H21F3N2O5