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Murcko scaffold

Ring system with 3 rings and 17 atoms

55 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
55
With full pages
14
Scaffold SMILES

O=C(Nc1cc2c(s1)CCCC2)c1ccco1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1cc2c(s1)CCCC2)c1ccco1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 55 chemicals

N-(3-Carbamoyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)furan-2-carboxamide chemical structure, C14H14N2O3S, CAS 303793-30-8
N-(3-Carbamoyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)furan-2-carboxamide
CAS 303793-30-8C14H14N2O3S
2-[(5-Methylfuran-2-carbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid chemical structure, C15H15NO4S, CAS 315683-65-9
2-[(5-Methylfuran-2-carbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid
CAS 315683-65-9C15H15NO4S
N-[3-(Diethylcarbamoyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]furan-2-carboxamide chemical structure, C18H22N2O3S, CAS 342390-57-2
N-[3-(Diethylcarbamoyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]furan-2-carboxamide
CAS 342390-57-2C18H22N2O3S
Ethyl 2-(2-furoylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C16H17NO4S, CAS 61600-71-3
Ethyl 2-(2-furoylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 61600-71-3C16H17NO4S
2-(Furan-2-carbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid chemical structure, C14H13NO4S, CAS 301157-00-6
2-(Furan-2-carbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid
CAS 301157-00-6C14H13NO4S
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-5-nitrofuran-2-carboxamide chemical structure, C14H11N3O4S, CAS 532963-59-0
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-5-nitrofuran-2-carboxamide
CAS 532963-59-0C14H11N3O4S
N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)furan-2-carboxamide chemical structure, C14H12N2O2S, CAS 61600-70-2
N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)furan-2-carboxamide
CAS 61600-70-2C14H12N2O2S
Methyl 2-[(furan-2-ylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C15H15NO4S, CAS 328025-36-1
Methyl 2-[(furan-2-ylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 328025-36-1C15H15NO4S
Methyl 2-[(5-bromo-2-furoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C15H14BrNO4S, CAS 356562-15-7
Methyl 2-[(5-bromo-2-furoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 356562-15-7C15H14BrNO4S
5-Bromo-N-(3-carbamoyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)furan-2-carboxamide chemical structure, C14H13BrN2O3S, CAS 356094-60-5
5-Bromo-N-(3-carbamoyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)furan-2-carboxamide
CAS 356094-60-5C14H13BrN2O3S
N-[3-(Dipropylcarbamoyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]furan-2-carboxamide chemical structure, C20H26N2O3S, CAS 342390-58-3
N-[3-(Dipropylcarbamoyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]furan-2-carboxamide
CAS 342390-58-3C20H26N2O3S
Ethyl 2-[(5-bromofuran-2-carbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C16H16BrNO4S, CAS 329219-63-8
Ethyl 2-[(5-bromofuran-2-carbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 329219-63-8C16H16BrNO4S
N-{3-[(3-Hydroxypropyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}furan-2-carboxamide chemical structure, C17H20N2O4S, CAS 455918-22-6
N-{3-[(3-Hydroxypropyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}furan-2-carboxamide
CAS 455918-22-6C17H20N2O4S
2-Methoxyethyl 2-[(5-bromofuran-2-carbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C17H18BrNO5S, CAS 444926-16-3
2-Methoxyethyl 2-[(5-bromofuran-2-carbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 444926-16-3C17H18BrNO5S
2-Methoxyethyl 2-(2-furoylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C17H19NO5S, CAS 495381-69-6
2-Methoxyethyl 2-(2-furoylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 495381-69-6C17H19NO5S
Propyl 2-[(5-bromofuran-2-carbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C17H18BrNO4S, CAS 354547-99-2
Propyl 2-[(5-bromofuran-2-carbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 354547-99-2C17H18BrNO4S
N-{3-[(3-Methoxypropyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}furan-2-carboxamide chemical structure, C18H22N2O4S, CAS 435287-26-6
N-{3-[(3-Methoxypropyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}furan-2-carboxamide
CAS 435287-26-6C18H22N2O4S
N-[3-(Prop-2-en-1-ylcarbamoyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]furan-2-carboxamide chemical structure, C17H18N2O3S, CAS 432015-87-7
N-[3-(Prop-2-en-1-ylcarbamoyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]furan-2-carboxamide
CAS 432015-87-7C17H18N2O3S
N-{3-[(2-Methoxyethyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}furan-2-carboxamide chemical structure, C17H20N2O4S, CAS 380583-53-9
N-{3-[(2-Methoxyethyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}furan-2-carboxamide
CAS 380583-53-9C17H20N2O4S
5-Bromo-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)furan-2-carboxamide chemical structure, C14H11BrN2O2S, CAS 329219-61-6
5-Bromo-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)furan-2-carboxamide
CAS 329219-61-6C14H11BrN2O2S
Methyl 2-[(furan-2-ylcarbonyl)amino]-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C16H17NO4S, CAS 329221-82-1
Methyl 2-[(furan-2-ylcarbonyl)amino]-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 329221-82-1C16H17NO4S
Isopropyl 2-(2-furoylamino)-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C18H21NO4S, CAS 329221-80-9
Isopropyl 2-(2-furoylamino)-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 329221-80-9C18H21NO4S
5-Bromo-N-(3-cyano-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)furan-2-carboxamide chemical structure, C15H13BrN2O2S, CAS 314022-14-5
5-Bromo-N-(3-cyano-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)furan-2-carboxamide
CAS 314022-14-5C15H13BrN2O2S
Isopropyl 2-[(5-bromo-2-furoyl)amino]-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C18H20BrNO4S, CAS 314023-40-0
Isopropyl 2-[(5-bromo-2-furoyl)amino]-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 314023-40-0C18H20BrNO4S